This study develops a novel cervical precancerous detection system by using texture analysis of¯eld emission scanning electron microscopy (FE-SEM) images. The processing scheme adopted in the proposed system focused on two steps. The¯rst step was to enhance cervical cell FE-SEM images in order to show the precancerous characterization indicator. A problem arises from the question of how to extract features which characterize cervical precancerous cells. For the¯rst step, a preprocessing technique called intensity transformation and morphological operation (ITMO) algorithm used to enhance the quality of images was proposed. The algorithm consisted of contrast stretching and morphological opening operations. The second step was to characterize the cervical cells to three classes, namely normal, low grade intra-epithelial squamous lesion (LSIL), and high grade intra-epithelial squamous lesion (HSIL). To di®eren-tiate between normal and precancerous cells of the cervical cell FE-SEM images, human papillomavirus (HPV) contained in the surface of cells were used as indicators. In this paper, we investigated the use of texture as a tool in determining precancerous cell images based on the observation that cell images have a distinct visual texture. Gray level co-occurrences matrix (GLCM) technique was used to extract the texture features. To con¯rm the system's performance, the system was tested using 150 cervical cell FE-SEM images. The results showed that the accuracy, sensitivity and speci¯city of the proposed system are 95.7%, 95.7% and 95.8%, respectively.