Intelligent system design for bionanorobots in drug delivery

Abstract

A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future.

Two ‘braking mechanisms’ for tin phthalocyanine molecular rotors on dipolar iron oxide surfaces

“…Fabrication and manipulation of molecular rotors and motors are crucial for articial molecular machines, [1][2][3][4][5] which will most likely be used in the elds of intelligent materials, sensors, nano-medicine and so on. [6][7][8][9] In fact, mechanical motions at the molecular scale exist everywhere and play important roles in nature, 10,11 for example, the kinesin protein linear motion powered by adenosine triphosphate hydrolysis, 12 the transportation of cellular cytoplasm through vesicles and the whole bacterial locomotion driven by rotational agella. 13 Observations of these natural machines have attracted special interest to develop analogous articial devices of nanoscale sizes and with controllable properties.…”

Enhancing Clinical Translation of Cancer Using Nanoinformatics

“…In order to have precise modeling of tracking behavior and data transferring, some control tools such as AI, neural networks and fuzzy logic must be used. In the treatment of tumor cells, it is suggested to use a fuzzy logic-based intelligent system to decrease the false-positive rate in the diagnosis and increase controlled drug delivery [92]. In fact, the inspiration for in vivo applications of bio micro/nanorobots is to deliver precision drugs with greater speed to the target tumor.…”

Investigating conformational changes of Prefoldin β1 as result of applying external mechanical force without any position constraint

“…Fletcher et al [5] proposed a fuzzy logic-based intelligent system to navigate bio-nanorobots inside the blood vessels for diagnosis and curing by effective drug dosage delivery into the tumour cells.…”