Intelligent temperature-pH dual responsive nanocellulose hydrogels and the application of drug release towards 5-fluorouracil

Li, Yuan; Zhang, Lu; Song, Zhaoping; Li, Fayong; Xie, Dong

doi:10.1016/j.ijbiomac.2022.10.188

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…After magnetic modification ( Figure 2 b), the individual CNF appeared to be invisible, and the CNF incorporated with Fe 3 O 4 was clearly indicated. In comparison with the morphology of CNF and MMCNF (see Figure 2 a,b), the responsive (semi-IPN) consisting of PNIPAM grafted CNF ( Figure 2 c–e) appeared to have a more porous structure, which might be due to the polymer having formed a certain number of channels or pores in the composites via grafting [ 19 ]. Furthermore, in comparison with the images obtained from MMCNF-PNA-1 ( Figure 2 c), the more porous structure could be observed on the image of MMCNF-PNA-3 ( Figure 2 e), implying more polymer chains grafted on MMCNF-PNA-3.…”

Section: Resultsmentioning

confidence: 99%

“…The second stage of the thermal decomposition happened at the temperature of 310 °C, which was related to the major thermal decomposition of CNF. The third thermal decomposition stage occurred at 383 °C, corresponding to the degradation of the PNIPAM modified CNF [ 19 , 20 ]. Meanwhile, from the curves shown in Figure 3 b, the thermal degradation of the MMCNF-PNA-3 happened at 310 °C with the maximum weight loss observed, showing a 5 °C change lower than that of CNF.…”

Section: Resultsmentioning

confidence: 99%

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Preparation and Application of Responsive Nanocellulose Composites

Zhou,

Zhang,

2024

Polymers

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Cellulose nanofibrils/poly(N-Isopropylacrylamide) semi-interpenetrating networks (MMCNF-PNAs) were synthesized using an in situ fabrication (semi-IPN). The polymerization of N-isopropylacrylamide (NIPAM) (free radical) was conducted in the presence of magnetic modified cellulose nanofibrils (MMCNFs). The adsorption behaviors and surface morphology of the synthesized adsorbents were investigated systematically. The adsorption behaviors of the as-prepared MMCNF-PNA towards methylene blue (MB, as the model contaminant) dye was studied, and the optimal adsorption conditions were also studied. The adsorption processes could be well fitted using pseudo-second-order and Elovich kinetic models. Meanwhile, Langmuir and Freundlich isotherm models were used to fit the adsorption which occurred at 25, 37 and 65 °C. The corresponding results showed that the Freundlich isotherm model fitted the adsorption process better, indicating that the dye’s adsorption happened via heterogeneous adsorptive energies on the prepared MMCNF-PNAs. Their desorption and reusability were also studied to verify magnetic responsivity. To sum up, MMCNF-PNAs are promising magnetic and thermal stimuli-responsive adsorbents, showing a controlled adsorption/desorption process.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Preparation and Application of Responsive Nanocellulose Composites

Zhou,

Zhang,

2024

Polymers

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“…(3) Intelligent drug release control: Smart hydrogels are particularly effective for targeting tumors due to their capacity to respond to various external stimuli and precisely regulate drug release [104][105][106]. (4) Accessibility: Hydrogels can be easily synthesized and mass-produced through chemical methods with a low ecological impact [107][108][109].…”

Section: Advantages Of Hydrogels In the Treatment Of Brain Tumorsmentioning

confidence: 99%

Advances in Hydrogels of Drug Delivery Systems for Local Treatment of Brain Tumors

Yang,

Wang,

et al. 2024

Preprint

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The management of brain tumors presents numerous challenges, despite the employment of multimodal therapies including surgical intervention, radiotherapy, chemotherapy, and immunotherapy. Owing to the distinct location of brain tumors and the presence of the blood-brain barrier (BBB), these tumors exhibit considerable heterogeneity and invasiveness at a histological level. Recent advancements in hydrogel research for the local treatment of brain tumors have sought to overcome the primary challenge of delivering therapeutics past the BBB, thereby ensuring efficient accumulation within brain tumor tissues. This article elaborates on various hydrogel-based delivery vectors, examining their efficacy in the local treatment of brain tumors. Additionally, it reviews the fundamental principles involved in designing intelligent hydrogels that can circumvent the BBB and penetrate larger tumor areas, thereby facilitating precise, controlled drug release. Hydrogel-based drug delivery systems (DDSs) are posited to offer a groundbreaking approach in addressing the challenges and limitations inherent in traditional oncological therapies, which are significantly impeded by the unique structural and pathological characteristics of brain tumors.

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“…Compared with the traditional way of forming hydrogels, smart hydrogels that can be adapted to different external conditions in order to meet different therapeutic needs are attracting more and more attention. 71 Thermosensitive hydrogels are the most widely studied smart hydrogels for dental applications. They can adapt to irregular and deep wound defective areas of periodontal pockets as much as possible in the solution state, and the gel cures when the ambient temperature is converted to physiological temperature, which facilitates the filling of the stent and prolongs the drug release.…”

Section: Advances In Hydrogel For Periodontitis Treatmentmentioning

confidence: 99%