Intelligent Tumor Microenvironment-Activated Multifunctional Nanoplatform Coupled with Turn-on and Always-on Fluorescence Probes for Imaging-Guided Cancer Treatment

Sun, Yudong; Wang, Yifei; Liu, Yaqi; Weng, Benrui; Yang, Huiran; Xiang, Zhouxuan; Ran, Jiabing; Wang, Huimin; Yang, Changying

doi:10.1021/acsami.1c17642

Cited by 25 publications

(17 citation statements)

References 51 publications

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“…The multifunctional nanoparticles are introduced with light/heat/physical dynamics for cancer therapy with synergistic therapy. [455][456][457] For example, Sun et al 458 constructed a multifunctional nanoplatform (AMIT) based on Au nanoclusters (AuNCs) coated with MnO 2 to codeliver ICG and the aptamer AS141 for targeting and image-guided PDT/CDT/PTT (Figure 5). The TME-responsive dissociation of MnO 2 could produce O 2 to enhance ICG-guided PDT and produce Mn 2+ for Fentonlike reaction-mediated CDT.…”

Section: Synergistic Therapymentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Synergistic Therapymentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…Sun et al . reported a multimodal nanoprobe that utilizes the TME for triple therapeutic effect through PDT, chemodynamic therapy and PTT with MRI and fluorescent imaging capabilities 189 . The AS1411 targeted probe consisting of gold nanocluster and ICG encapsulated by MnO 2 , is able to produce O 2 in the H 2 O 2 -rich TME and releases its content through GSH-mediated degradation.…”

Section: Aptamers For Theranostic Applicationsmentioning

confidence: 99%

Aptamers used for molecular imaging and theranostics - recent developments

Bohrmann¹,

Burghardt²,

Haynes³

et al. 2022

Theranostics

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Aptamers are single stranded oligonucleotides that fold into three dimensional structures and are able to recognize a variety of molecular targets. Due to the similarity to antibodies with regards to specificity and affinity and their chemical versatility, aptamers are increasingly used to create targeted probes for in vivo molecular imaging and therapy. Hence, aptamer-based probes have been utilized in practically all major imaging modalities such as nuclear imaging, magnetic resonance imaging, x-ray computed tomography, echography and fluorescence imaging, as well as newer modalities such as surface enhanced Raman spectroscopy. Aside from targeting, aptamers have been used for the creation of sensors that allow the localized detection of cellular markers such as ATP in vivo . This review focuses on in vivo studies of aptamer-based probes for imaging and theranostics since the comprehensive overview by Bouvier-Müller and Ducongé in 2018.

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“…Recently, an intelligent multifunctional nanoplatform was constructed via a simple and green BSA‐mediated biomineralization synthesis method for TME activatable imaging‐guided PDT, CDT, and PTT. [ 169 ] The in vitro and in vivo experimental results showed that the combined effect of the nanocomposite triggered by MnO 2 caused a high tumor inhibition performance, and achieved the fluorescence, magnetic resonance, and photothermal imaging at the same time. In a newly assembled PdH@MnO 2 /Ce6@HA (PHMCH) yolk–shell nanoplatform, [ 170 ] the PdH tetrahedron has a highly efficient hydrogen release behavior controlled by NIR and a significant photothermal effect.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Integration of Manganese Dioxide‐Based Nanomaterials for Biomedical Applications

Sun

Wang

Liu

et al. 2022

Advanced NanoBiomed Research

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Advancements in nanotechnology have promoted the rapid development of diverse nanosystems for biomedical applications. Manganese dioxide (MnO2) nanomaterials have attracted numerous attentions in the field of biosensing and cancer treatment due to their unique properties, such as simple fabrication procedures, broad optical absorption, and high oxidation and catalytic ability. Especially, the intelligent stimuli‐responsiveness of MnO2 nanomaterials to tumor microenvironment (TME) greatly improves their performance in tumor imaging and cancer therapy. In this review, the synthetic methods of different MnO2 nanostructures (nanoparticles, nanosheets, and nanoflowers) are first introduced, followed by the introduction of MnO2 nanomaterials for various biosensing applications based on their unique characteristics. Then, the recent achievements and progress of MnO2 nanomaterials for cancer treatment are comprehensively summarized with a focus on various therapeutic enhancements profiting from their disassembled ingredients under TME guidance. Finally, the current challenges and future perspectives of this promising research are discussed in the fields of biomedicine.

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Intelligent Tumor Microenvironment-Activated Multifunctional Nanoplatform Coupled with Turn-on and Always-on Fluorescence Probes for Imaging-Guided Cancer Treatment

Cited by 25 publications

References 51 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Aptamers used for molecular imaging and theranostics - recent developments

Integration of Manganese Dioxide‐Based Nanomaterials for Biomedical Applications

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