Intense near-infrared-II luminescence from NaCeF4:Er/Yb nanoprobes forin vitrobioassay andin vivobioimaging

Lei, Xialian; Li, Renfu; Tu, Datao; Shang, Xiaoying; Liu, Yan; You, Wenwu; Sun, Chia‐Chung; Zhang, Fan; Chen, Xueyuan

doi:10.1039/c8sc00927a

Cited by 152 publications

(103 citation statements)

References 37 publications

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“…Thus, it has emerged as the next-generation imaging technique for in vivo biomedical imaging. [23][24][25][26][27][28][29][30][31] Nevertheless, like most of reported NIR-II inorganic nanoparticles, long retention in reticuloendothelial system (RES) and inability to clear from living body lead to the existing dilemmas in the RENPs, which also raise the potential safety concerns and greatly hamper their future broad biomedical applications and translation. [20][21][22][23][24] However, tedious synthetic procedure and low quantum yield of organic molecules are still the main chemical impediments that make them lie behind the inorganic counterparts.…”

Section: Introductionmentioning

confidence: 99%

Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window

et al. 2019

Advanced Science

100

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Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained in the reticuloendothelial system (RES) such as the liver and spleen, leading to long-term safety concerns. Herein, a type of lanthanide-based excretable NIR-II nanoparticle, RENPs@Lips, which can be quickly cleared out of body after intravenous administration with half-lives of 23.0 h for the liver and 14.9 h for the spleen, is reported. Interestingly, over 90% of RENPs@Lips can be excreted through a hepatobiliary system within 72 h postinjection. The moderate blood half-time (T 1/2 = 17.96 min) allows for multifunctional applications in delineating the hemodynamics of vascular disorders (artery thrombosis, ischemia, and tumor angiogenesis) and monitoring blood perfusion in response to acute ischemia. In addition, RENPs@Lips exhibit high performance in identifying orthotopic tumor vessels intraoperatively and embolization surgery under NIR-II imaging navigation. Moreover, excellent signal-to-background ratio (SBR) is successfully achieved to facilitate sentinel lymph nodes biopsy (SLNB) with tumor-bearing mice. The high biocompatibility, favorable excretability, and outstanding optical properties warrant RENPs@Lips as novel promising NIR-II nanoparticles for future applications and translation into an interdisciplinary amalgamation of research in diverse fields.

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Section: Introductionmentioning

confidence: 99%

Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window

et al. 2019

Advanced Science

100

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“…To render the hydrophobic CaS:Ln 3+ NPs hydrophilic, we coated the NPs with alayer of Lipo through ligand adsorption (Figure 4a). [14] Thes uccessful conjugation of Lipo to the NP surface was verified by FTIR spectroscopy,T EM, thermogravimetric analyses,a nd dynamic light scattering measurements ( Figure S8-S10). TheL ipo-coated NPs preserved intense NIR-II luminescence from their pristine oleatecapped NPs with nearly unchanged PL intensities and PL lifetimes ( Figure S11 and S12).…”

mentioning

confidence: 87%

“…Er 3+ concentration-dependent a) PL emission spectra (l ex = 450 nm), and PL decays from b) 4 I 13/2 level of Er 3+ and c) 5d state of Ce 3+ in CaS:0.07 %Ce 3+ , x%Er 3+ NPs by monitoring the Er 3+ and Ce 3+ emissions at 1540 nm and 565 nm, respectively.Nd 3+ concentration-dependent d) PL emission spectra (l ex = 450 nm), and PL decays from e) 4 F 3/2 level of Nd 3+ and f) 5d state of Ce 3+ in CaS:0.07 %Ce 3+ , x%Nd 3+ NPs by monitoring the Nd 3+ and Ce 3+ emissions at 1070 nm and 565 nm, respectively.g)Schematic of the ET from Ce 3+ to Er 3+ and Nd 3+ in CaSNPs. [14] Therefore,t he H 2 O 2 concentration can be quantified by measuring the NIR-II PL of CaS:Ce 3+ ,Er 3+ NPs (Figure S17 b). of the NPs under blue-LED excitation by addition of different amounts of H 2 O 2 .I tw as found that the integrated PL intensity of Er 3+ in the NPs decreased gradually with increasing time and H 2 O 2 concentration (Figure 4c and Figure S17 a) as ar esult of the decreased ET from Ce 3+ to Er 3+ as Ce 3+ is oxidized by H 2 O 2 .…”

mentioning

confidence: 99%

A New Class of Blue‐LED‐Excitable NIR‐II Luminescent Nanoprobes Based on Lanthanide‐Doped CaS Nanoparticles

et al. 2019

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Lanthanide (Ln 3+ )-doped luminescent nanoparticles (NPs) with emission in the second near-infrared (NIR-II) biological windowh ave shown great promise but their applications are currently limited by the lowa bsorption efficiency of Ln 3+ owing to the parity-forbidden 4f!4f electronic transition. Herein, we developed as trategy for the controlled synthesis of an ew class of NIR-II luminescent nanoprobes based on Ce 3+ /Er 3+ and Ce 3+ /Nd 3+ co-doped CaS NPs,which can be effectively excited by using alow-cost blue light-emitting diode chip.Through sensitization by the allowed 4f!5d transition of Ce 3+ ,i ntense NIR-II luminescence from Er 3+ and Nd 3+ with quantum yields of 9.3 %a nd 7.7 %w as achieved, respectively.B yc oating them with al ayer of amphiphilic phospholipids,these NPs exhibit excellent stability in water and can be exploited as sensitive NIR-II luminescent nanoprobes for the accurate detection of an important disease biomarker,xanthine,with adetection limit of 32.0 nm.

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“…[77] Copyright 2016, American Chemical Society. [75] Apart from emitter and sensitizer ion dopant amounts, Prasad and coworkers also demonstrated a significant enhancement of NIR II emission when using inert shells. Reproduced with permission.…”

Section: Optimization Of Rare Earth-doped Nanoprobesmentioning

confidence: 99%

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

Liu

Jia

Zhou

2018

Advanced Therapeutics

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With the advantages of low biofluid scattering and minimal absorbance, light in a second near-infrared window (NIR II, 1000-1700 nm) either as a signal or as an excitation source is preferred for bioimaging and disease diagnosis, especially for cancer theranostics. Due to recent advances in chemical synthesis and imaging techniques, various NIR II probes have been evaluated for tumor luminescence image-guided cancer therapy and surgery. Furthermore, probes emitting optical, acoustic, or thermal signals under NIR II excitation have also been developed for upconversion luminescence, photoacoustic, and photothermal imaging of tumors. Herein, recent advances in the use of NIR II imaging probes in cancer theranostic applications are summarized along with future perspectives.

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Intense near-infrared-II luminescence from NaCeF₄:Er/Yb nanoprobes forin vitrobioassay andin vivobioimaging

Abstract: We report the controlled synthesis of monodisperse NaCeF4:Er/Yb nanoprobes that exhibit intense NIR-II emission for in vitro bioassay and in vivo bioimaging.

Cited by 152 publications

References 37 publications

Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window

Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window

A New Class of Blue‐LED‐Excitable NIR‐II Luminescent Nanoprobes Based on Lanthanide‐Doped CaS Nanoparticles

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

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