Intensity-detection-based guided-mode-resonance optofluidic biosensing system for rapid, low-cost, label-free detection

Lin, Ying‐Chih; Hsieh, Wen‐Hsin; Chau, Lai-Kwan; Chang, Guo‐En

doi:10.1016/j.snb.2017.04.187

Cited by 44 publications

(41 citation statements)

References 52 publications

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“…An alternative class of optical sensor exists, known as a guided mode resonance filter [4,5], leaky-mode reflector [6], resonant waveguide grating [7], or, as it will referred to here, a photonic crystal slab (PCS) sensor [8]. Compared to SPR, this sensor can be read out using much simpler instrumentation, such as an LED and a photodiode [9,10] or even a smartphone [11]. Roll-to-roll high-throughput fabrication was demonstrated at an early stage [12], and microwell plates with PCS sensors on the bottom are commercially available, e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of water-absorption and thermal drift on a polymeric photonic crystal slab sensor

Sørensen¹,

Ingvorsen²,

Nielsen³

2018

Opt. Express

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A photonic crystal slab (PCS) sensor is a universal refractive index sensor with possibilities and performance very similar to surface plasmon resonance (SPR), which represents the gold standard of biosensing. Cheap PCS sensors can be made vacuum-free entirely out of polymers, but come with additional challenges, besides those relating to temperature-variations, which must be considered in any refractive index based method: The polymeric waveguide core was found to swell by ∼0.3% as water absorbed into the waveguide core over ∼1.5 h. This was investigated by monitoring the wavelength of resonant reflection during absorption, by monitoring the release of water using ellipsometry, and by rigorous coupled-wave analysis (RCWA). The approach presented here enables monitoring of water uptake and thermal fluctuations, for drift-free, high-performance operation of a polymeric PCS sensor.

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Section: Introductionmentioning

confidence: 99%

Effects of water-absorption and thermal drift on a polymeric photonic crystal slab sensor

Sørensen¹,

Ingvorsen²,

Nielsen³

2018

Opt. Express

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“…Wavelength interrogation using a broadband light source and high-resolution spectrometers [ 11 , 13 ] is probably the most straightforward detection method. Detection techniques using tunable light sources and photodetectors [ 14 , 15 , 16 ], angle [ 10 ] and intensity [ 17 ] modulation, and phase interrogation [ 18 ] have also been successfully demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Gradient Waveguide Thickness Guided-Mode Resonance Biosensor

Yang

Chen

et al. 2021

Sensors

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Portable systems for detecting biomolecules have attracted considerable attention, owing to the demand for point-of-care testing applications. This has led to the development of lab-on-a-chip (LOC) devices. However, most LOCs are developed with a focus on automation and preprocessing of samples; fluorescence measurement, which requires additional off-chip detection instruments, remains the main detection method in conventional assays. By incorporating optical biosensors into LOCs, the biosensing system can be simplified and miniaturized. However, many optical sensors require an additional coupling device, such as a grating or prism, which complicates the optical path design of the system. In this study, we propose a new type of biosensor based on gradient waveguide thickness guided-mode resonance (GWT-GMR), which allows for the conversion of spectral information into spatial information such that the output signal can be recorded on a charge-coupled device for further analysis without any additional dispersive elements. A two-channel microfluidic chip with embedded GWT-GMRs was developed to detect two model assays in a buffer solution: albumin and creatinine. The results indicated that the limit of detection for albumin was 2.92 μg/mL for the concentration range of 0.8–500 μg/mL investigated in this study, and that for creatinine it was 12.05 μg/mL for the concentration range of 1–10,000 μg/mL. These results indicated that the proposed GWT-GMR sensor is suitable for use in clinical applications. Owing to its simple readout and optical path design, the GWT-GMR is considered ideal for integration with smartphones or as miniaturized displays in handheld devices, which could prove beneficial for future point-of-care applications.

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“…The optical RI sensing is one of the most suitable techniques for the applications mentioned above because the sensors do not require the electrical wiring. Many kinds type of RI optical sensing devices have been developed so far using optical resonances in metal surfaces [ 1 , 8 , 9 , 10 , 11 ], nano particles [ 2 , 3 , 12 , 13 , 14 ], nanorings [ 15 , 16 , 17 ], waveguides [ 18 , 19 , 20 , 21 , 22 ], gratings [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], photonic crystals [ 31 , 32 , 33 , 34 ], and microstructured optical fibers [ 35 , 36 , 37 ]. The systems of RI sensing based on surface plasmon resonance (SPR) have been widely used and been commercialized.…”

Section: Introductionmentioning

confidence: 99%

GaN-Based High-Contrast Grating for Refractive Index Sensor Operating Blue–Violet Wavelength Region

Takashima

Haraguchi

Naoi

2020

Sensors

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Owing to its versatility, optical refractive index (RI) sensors with compact size and high chemical stability are very suitable for a wide range of the applications in the internet of things (IoT), such as immunosensor, disease detection, and blood mapping. In this study, a RI sensor with very simple system and high chemical stability was developed using GaN-based high-contrast grating (HCG). The designed HCG pattern was fabricated on GaN-film grown on c-plane sapphire substrate. The fabricated GaN-HCG sensor can detect minuscule RI change of 1.71 × 10–3 with extreme simple surface normal irradiation system. The light behavior inside the GaN-HCG was discussed using numerical electromagnetic field calculation, and the deep understand of the sensing mechanism was provided. The simple system and very high chemical stability of our sensor exploit RI sensing applications in IoT society.

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Intensity-detection-based guided-mode-resonance optofluidic biosensing system for rapid, low-cost, label-free detection

Cited by 44 publications

References 52 publications

Effects of water-absorption and thermal drift on a polymeric photonic crystal slab sensor

Effects of water-absorption and thermal drift on a polymeric photonic crystal slab sensor

Gradient Waveguide Thickness Guided-Mode Resonance Biosensor

GaN-Based High-Contrast Grating for Refractive Index Sensor Operating Blue–Violet Wavelength Region

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