2004
DOI: 10.1016/j.ijrobp.2003.11.003
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Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome

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Cited by 150 publications
(81 citation statements)
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“…Several publications on pancreatic cancer have demonstrated the superiority of IMRT in reducing radiation doses to surrounding normal organs in comparison to three-dimensional conformal radiotherapy [2,4,23,24,34]. Our analysis in ten patients revealed that RA allowed for an improved CI relative Table 3.…”
Section: Discussionmentioning
confidence: 72%
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“…Several publications on pancreatic cancer have demonstrated the superiority of IMRT in reducing radiation doses to surrounding normal organs in comparison to three-dimensional conformal radiotherapy [2,4,23,24,34]. Our analysis in ten patients revealed that RA allowed for an improved CI relative Table 3.…”
Section: Discussionmentioning
confidence: 72%
“…A "small-bowel region" was defined which consisted of the abdominal content after subtracting the PTV, all OARs and the vertebral bodies, with the posterior border extending to the dorsum of the lumbar vertebral body, but excluding the retroperitoneal space [30]. Our definition of a "small-bowel region" also included the mesentery and intraperitoneal fat, which is in contrast with prior reports describing bowel dose-volume relationships using bowel loop contouring [23,24].…”
Section: Methodsmentioning
confidence: 99%
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“…It may also allow for dose escalation and a consequent greater tumor control probability. Milano et al [75], in an efficacy and toxicity finding study of IMRT in pancreatic and bile duct cancer, treated 25 patients with IMRT and concurrent 5-FU. IMRT was well tolerated and reduced the mean dose to the liver, kidneys, stomach, and small bowel, with 80% of patients experiencing grade 2 toxicity only.…”
Section: Intensity-modulated Radiotherapymentioning
confidence: 99%