Intensity of pelage pigmentation and reproductive ability in sables (Martez zibellina L.)

Kashtanov, S. N.; Lazebny, O. E.; Njukhalov, A. P.; Chernova, I. E.; Svishcheva, G. R.; Трапезов, О. В.

doi:10.1134/s2079059714060112

Cited by 2 publications

(3 citation statements)

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“…We suggest that the identified variant in TYRP1 is causative for the pastel sable phenotype in the Puschkinsky State Fur Farm sable population. According to archive data, the Puschkinsky State Fur Farm population was formed from 1000 sables from natural populations of several regions in Siberia and the Far East [ 4 , 5 ]. To test the hypothesis that the pastel variant may be present in wild sable populations, we performed genotyping of animals from several natural populations ( Table S1 ) for the TYPR1 b variant.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, we used sample collections of 44 wild sables from natural populations ( Table S1 ). The populations were selected on the basis of the archive data analysis, which demonstrated that the Puschkinsky sable farm population was formed in the years between 1929 and 1947 by animals from the eastern part of the species’ range [ 4 , 5 ]. The biological samples were collected during the period from 2012 to 2019 in the area where sable hunting is legal.…”

Section: Methodsmentioning

confidence: 99%

“…During that time, the first sable farms, where animals are maintained in cages, were created. The initial gene pool of sable farm populations in Russia was formed in the Puschkinsky State Fur Farm, Moscow region (established in 1929), by crossing approximately 1000 animals from natural populations in Siberia and the Far East [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Genome Analysis of Sable Fur Color Links a Lightened Pigmentation Phenotype to a Frameshift Variant in the Tyrosinase-Related Protein 1 Gene

Manakhov

Mintseva

Andreeva

et al. 2021

Genes

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Sable (Martes zibellina) is one of the most valuable species of fur animals. Wild-type sable fur color varies from sandy-yellow to black. Farm breeding and 90 years of directional selection have resulted in a generation of several sable breeds with a completely black coat color. In 2005, an unusually chocolate (pastel) puppy was born in the Puschkinsky State Fur Farm (Russia). We established that the pastel phenotype was inherited as a Mendelian autosomal recessive trait. We performed whole-genome sequencing of the sables with pastel fur color and identified a frameshift variant in the gene encoding membrane-bound tyrosinase-like enzyme (TYRP1). TYRP1 is involved in the stability of the tyrosinase enzyme and participates in the synthesis of eumelanin. These data represent the first reported variant linked to fur color in sables and reveal the molecular genetic basis for pastel color pigmentation. These data are also useful for tracking economically valuable fur traits in sable breeding programs.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%