Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Bhagat, Hemant; Dash, Hari H.; Chauhan, Ramesh Chand; Khanna, Puneet; Bithal, Parmod K.

doi:10.4103/2348-0548.139106

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…We have male: female ratio 2.8:1which is comparable to studies done by Maneesh et al 10 (male: female 2.3:1), Gang Zhang et al 11 (1.83:1), Hemant bhagat et.al 12 (3:1). In present study 100% cases presented with some motor weakness out of which 97%cases had quadriparesis, 2% had paraparesis and only one case had brachiparesis.…”

Section: Discussionsupporting

confidence: 89%

Study of clinical profile and prognosis in various subtypes of guillain barre syndrome patients

Ralot¹,

Parmar²,

Gujar³

et al. 2020

IJN

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Guillain-Barré syndrome is a post infective polyradiculoneuropathy having heterogenous clinical presentation and various subtypes like acute inflammatory demyelinating polyradiculoneuropathy, acute motor-sensory axonal neuropathy, acute motor axonal neuropathy, pure sensory variant and Miller Fisher syndrome. A prospective study was carried out in patients with Guillain-Barré syndrome admitted to the RNT Medical College & attached Hospital to determine the electrophysiological subtypes and their prognosis in relation to various subtypes, clinical features and treatment. A total of 100 patients was enrolled. In the final analysis there were 74% male and the mean age was 30.4 years. Clinically 97% patients had quadriparesis, 2% had paraparesis and one cases had bibrachial involvement. Cranial nerves and respiratory involvement were seen in 25% and 24% cases respectively. Electrophysiologically the most common type of GBS was AIDP (43%) followed by AMAN (34%) and AMSAN (23%). The prognosis was assessed at one month and found that there was complete recovery in 32% cases and residual weakness in 63% cases. Death occurred in 5% cases because of respiratory involvement.

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Section: Discussionsupporting

confidence: 89%

Study of clinical profile and prognosis in various subtypes of guillain barre syndrome patients

Ralot¹,

Parmar²,

Gujar³

et al. 2020

IJN

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“…The reason is probably related to the time that takes Wallerian degeneration to occur, which is longer for sensory than motor nerves and subsequently results in SNAP amplitude reduction to its nadir later than CMAP amplitude. 25 Lower amplitude of CMAP in the median and tibial nerves in the early phase of AIDP compared to axonal variants may be due to proximal CBs. With progression of time, CMAP amplitudes are decreased more in axonal types which reflected axonal degeneration.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological patterns in patient with Guillain-Barre syndrome

Hossain¹,

Ali

Rahman

et al. 2021

Birdem Med J

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Background: Guillain-Barre syndrome (GBS) is an acute, frequently severe and fulminant polyradiculoneuropathy that is autoimmune in nature. Incidence and predominant subtypes of GBS differ geographically. Electrophysiology has important role in subtyping GBS. This study aimed to evaluate the electrophysiological findings in patient of GBS. Methods: This was a hospital based cross-sectional descriptive study and conducted at the Department of Neurology in Sir Salimullah Medical College & Mitford Hospital, Dhaka and National Institute of Neurosciences and Hospital, Dhaka during July 2017 to June 2018. Clinically diagnosed 53 patients with GBS were enrolled according to prefixed selection criteria. Detail history taking, clinical examination, nerve conduction study and cerebrospinal fluid (CSF) examination was performed in all cases. Clinical findings, nerve conduction study (NCS) parameters, CSF findings and demographic profiles were evaluated. Results: Mean ± SD age of presentation was 41.64 (±14.56) years and median age was 42.0 years. There were total 33(62 %) males and 20 (38 %) females with male: female ratio of 1.7:1. Clinically two-thirds(62.3%) of patients had both upper and lower limb involvement (62.3%), facial weakness was in 32.1% and 13.2% had bulbar involvement. Acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN)were found to be 51%, 32% and 17% respectively. CSFprotein was elevated in most of the patients with a range of 16-725 mg/dl. Highest CSF protein was found in AIDP. Conclusion: Electrophysiological studies play an important role in the early detection; characterization of GBS.In this study, the commonest type of GBS was AIDP. Higher levels of CSF protein, absent H-reflex and Fresponse, sural sparing and unexcitable nerves are more frequently present in AIDP. BIRDEM Med J 2022; 12(1): 16-21

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“…Erythrocyte sedimentation rate (ESR) is a rapid, simple, inexpensive biomarker have been recommended all the time in the GBS work up, as a screening for the underlying inflammatory process. Many studies reported elevated ESR levels on the sideline of their investigations [13][14][15][16][17][18] . Among the Egyptian patients, our results were comparable to the results reported by Hashim and their colleagues who found that ESR levels showed statistically significant higher levels in GBS patients than in healthy subjects (p=0.017) [18] .…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Sedimentation Rate as An Inflammatory Biomarker for Prediction of Prognosis of Guillain-Barre Syndrome

Elsaid¹,

Eltoukhy²,

Saied³

2022

The Egyptian Journal of Hospital Medicine

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Background: Guillain-Barre syndrome (GBS) is an acute or subacute inflammatory autoimmune postinfectious polyradiculoneuropathy, usually triggered by antecedent infections during the preceding six weeks suggesting a humoral immune-pathogenic mechanism. Inflammation raises the erythrocyte sedimentation rate (ESR), which can be used to monitor the inflammatory process. Objective: This study aimed to find out if there is correlation between the ESR as a marker of the inflammatory process and the Erasmus GBS outcome score. Methods: Patients were diagnosed with GBS based Asbury and Cornblath diagnostic criteria. Assessment of GBS disability score and the Erasmus GBS outcome score (EGOS) were performed. Results: Among 37 patients with GBS; the GBS disability score was 3 in 13 patients (35.2%), and 4 in 24 patients (64.5%). None of our patients showed other grades of the GBS score. As regard the EGOS 4 patients (10.8%) scored 3, 3 (8.1%) scored 3.5, 11 (29.7%) scored 4, 6 (16.2%) scored 4.5, 10 (27.1%) scored 5, 2 (5.4%) scored 5.5, and only one patient (2.7%) scored 6. Assessed first hour ESR mean value was 42.97 ± 18.01, with minimum value of 16, maximum 110. Positive correlation between the ESR and the EGOS was detected with r value of 0.7328. Conclusion: ESR may serve as a simple prognostic biomarker of clinical severity as higher ESR levels were associated with increase severity of GBS.

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Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Cited by 7 publications

References 32 publications

Study of clinical profile and prognosis in various subtypes of guillain barre syndrome patients

Study of clinical profile and prognosis in various subtypes of guillain barre syndrome patients

Electrophysiological patterns in patient with Guillain-Barre syndrome

Erythrocyte Sedimentation Rate as An Inflammatory Biomarker for Prediction of Prognosis of Guillain-Barre Syndrome

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