„Intensive Care Unit-Acquired Weakness“

Klawitter, Felix; Schaller, Stefan; Söhle, Martin; Reuter, Daniel A.; Ehler, Johannes

doi:10.1007/s00101-022-01089-9

Cited by 9 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-term practical work broadens and enrichens knowledge related to critical care and the ability to explore di cult problems. Moreover, they are more willing to take the initiative to care for children in the PICU compared to other personnel [22]. The study has some limitations.…”

Section: Overall Evaluation Of Kap Regarding Children With Icu-awmentioning

confidence: 95%

Knowledge, attitudes and practices regarding children with ICU-acquired weakness in Pediatric Intensive Care Unit among Chinese healthcare personnel: a cross-sectional survey

Huang

Zhang

Peng

et al. 2022

Preprint

View full text Add to dashboard Cite

Background To explore the knowledge, attitudes, and practices of Chinese medical staff regarding critically ill children with intensive care unit-acquired weakness (ICU-AW) and related factors. Methods A Knowledge, Attitudes, and Practices (KAP) Questionnaire regarding critically ill children with ICU-AW was distributed to a stratified sample of 530 pediatric intensive care unit (PICU) healthcare workers. The questionnaire consisted of 31 items—with scores of 45, 40, and 40 for each dimension and a total score of 125. Results The mean total score of Chinese PICU healthcare workers for the KAP questionnaire regarding children with ICU-AW was 87.36 ± 14.241 (53–121), with mean total knowledge, attitudes, and practices scores of 30.35 ± 6.317, 30.46 ± 5.632, and 26.54 ± 6.454, respectively. The population distribution indicated that 50.56%, 46.04%, and 3.4% of healthcare workers had poor, average, and good scores, respectively. Multiple linear regression showed that gender, education, and hospital level classification influenced the KAP level of PICU healthcare workers regarding critically ill children with ICU-AW. Conclusions Overall, PICU healthcare workers in China have an average KAP level about ICU-AW, and the gender and education level of PICU healthcare workers, as well as the classification of hospitals where they work, predict the KAP status of healthcare workers regarding children with ICU-AW. Therefore, healthcare leaders should plan and develop specific training programs to improve the KAP level of PICU healthcare workers.

show abstract

Section: Overall Evaluation Of Kap Regarding Children With Icu-awmentioning

confidence: 95%

Knowledge, attitudes and practices regarding children with ICU-acquired weakness in Pediatric Intensive Care Unit among Chinese healthcare personnel: a cross-sectional survey

Huang

Zhang

Peng

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Several risk factors are associated with CIW, with the main ones being prolonged inflammatory status [11][12][13], multiorgan failure, prolonged mechanical ventilation, and ICU length of stay [14]. As evidence, severity scores correlate highly with CIW [15].…”

Section: Risk Factorsmentioning

confidence: 99%

Critical illness-associated limb and diaphragmatic weakness

Le Stang,

Latronico,

Dres

et al. 2024

Current Opinion in Critical Care

View full text Add to dashboard Cite

Purpose of review In the current review, we aim to highlight the evolving evidence on the diagnosis, prevention and treatment of critical illness weakness (CIW) and critical illness associated diaphragmatic weakness (CIDW). Recent findings In the ICU, several risk factors can lead to CIW and CIDW. Recent evidence suggests that they have different pathophysiological mechanisms and impact on outcomes, although they share common risk factors and may overlap in several patients. Their diagnosis is challenging, because CIW diagnosis is primarily clinical and, therefore, difficult to obtain in the ICU population, and CIDW diagnosis is complex and not easily performed at the bedside. All of these issues lead to underdiagnosis of CIW and CIDW, which significantly increases the risk of complications and the impact on both short and long term outcomes. Moreover, recent studies have explored promising diagnostic techniques that are may be easily implemented in daily clinical practice. In addition, this review summarizes the latest research aimed at improving how to prevent and treat CIW and CIDW. Summary This review aims to clarify some uncertain aspects and provide helpful information on developing monitoring techniques and therapeutic interventions for managing CIW and CIDW.

show abstract

“…However, due to frequently impaired patient compliance, the clinical assessment of ICUAW may be difficult, so alternative diagnostic methods such as in vivo and in vitro biomarkers, neuromuscular ultrasound and electrodiagnostics have been investigated [ 5 , 6 , 7 ]. Their acceptance in daily clinical practice is, however, limited by the extended diagnostic effort for the ICU staff [ 4 , 8 ]. It must be noticed that ICUAW is an umbrella term to cover different pathophysiological conditions underlying this specific phenotype.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction in Intensive Care Unit-Acquired Weakness and Critical Illness Myopathy: A Narrative Review

Klawitter

Ehler

Bajorat

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Mitochondria are key structures providing most of the energy needed to maintain homeostasis. They are the main source of adenosine triphosphate (ATP), participate in glucose, lipid and amino acid metabolism, store calcium and are integral components in various intracellular signaling cascades. However, due to their crucial role in cellular integrity, mitochondrial damage and dysregulation in the context of critical illness can severely impair organ function, leading to energetic crisis and organ failure. Skeletal muscle tissue is rich in mitochondria and, therefore, particularly vulnerable to mitochondrial dysfunction. Intensive care unit-acquired weakness (ICUAW) and critical illness myopathy (CIM) are phenomena of generalized weakness and atrophying skeletal muscle wasting, including preferential myosin breakdown in critical illness, which has also been linked to mitochondrial failure. Hence, imbalanced mitochondrial dynamics, dysregulation of the respiratory chain complexes, alterations in gene expression, disturbed signal transduction as well as impaired nutrient utilization have been proposed as underlying mechanisms. This narrative review aims to highlight the current known molecular mechanisms immanent in mitochondrial dysfunction of patients suffering from ICUAW and CIM, as well as to discuss possible implications for muscle phenotype, function and therapeutic approaches.

show abstract

„Intensive Care Unit-Acquired Weakness“

Cited by 9 publications

References 30 publications

Knowledge, attitudes and practices regarding children with ICU-acquired weakness in Pediatric Intensive Care Unit among Chinese healthcare personnel: a cross-sectional survey

Knowledge, attitudes and practices regarding children with ICU-acquired weakness in Pediatric Intensive Care Unit among Chinese healthcare personnel: a cross-sectional survey

Critical illness-associated limb and diaphragmatic weakness

Mitochondrial Dysfunction in Intensive Care Unit-Acquired Weakness and Critical Illness Myopathy: A Narrative Review

Contact Info

Product

Resources

About