Intention to Split Policy

Battula, Narendra; Platto, Marco; Anbarasan, Ravindar; Perera, M Thamara P R; Ong, Evelyn; Roll, Garrett R.; Neto, Ben Hur Ferraz; Mergental, Hynek; Isaac, John; Muiesan, Paolo; Sharif, Khalid; Mirza, Darius F.

doi:10.1097/sla.0000000000001816

Cited by 82 publications

(36 citation statements)

References 37 publications

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“…nov., and this species thus represents yet another human clinical Burkholderia species with interesting biotechnological properties (Coenye et al, 2001 ; Coenye and Vandamme, 2003 ; Goris et al, 2004 ; Mahenthiralingam et al, 2005 ). This study therefore further underscores that there is no phylogenetic subdivision in the genus Burkholderia that distinguishes beneficial from pathogenic strains (Angus et al, 2014 ; Sawana et al, 2014 ; Estrada-de los Santos et al, 2016 ; Dobritsa and Samadpour, 2016 ).…”

Section: Discussionsupporting

confidence: 56%

Phylogenomic Study of Burkholderia glathei-like Organisms, Proposal of 13 Novel Burkholderia Species and Emended Descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae

et al. 2016

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Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei clade (BGC) bacteria. The taxonomic status of these clusters was examined by whole-genome sequence analysis, determination of the G+C content, whole-cell fatty acid analysis and biochemical characterization. The whole-genome sequence-based phylogeny was assessed using the Genome Blast Distance Phylogeny (GBDP) method and an extended multilocus sequence analysis (MLSA) approach. The results demonstrated that these 17 BGC isolates represented 13 novel Burkholderia species that could be distinguished by both genotypic and phenotypic characteristics. BGC strains exhibited a broad metabolic versatility and developed beneficial, symbiotic, and pathogenic interactions with different hosts. Our data also confirmed that there is no phylogenetic subdivision in the genus Burkholderia that distinguishes beneficial from pathogenic strains. We therefore propose to formally classify the 13 novel BGC Burkholderia species as Burkholderia arvi sp. nov. (type strain LMG 29317T = CCUG 68412T), Burkholderia hypogeia sp. nov. (type strain LMG 29322T = CCUG 68407T), Burkholderia ptereochthonis sp. nov. (type strain LMG 29326T = CCUG 68403T), Burkholderia glebae sp. nov. (type strain LMG 29325T = CCUG 68404T), Burkholderia pedi sp. nov. (type strain LMG 29323T = CCUG 68406T), Burkholderia arationis sp. nov. (type strain LMG 29324T = CCUG 68405T), Burkholderia fortuita sp. nov. (type strain LMG 29320T = CCUG 68409T), Burkholderia temeraria sp. nov. (type strain LMG 29319T = CCUG 68410T), Burkholderia calidae sp. nov. (type strain LMG 29321T = CCUG 68408T), Burkholderia concitans sp. nov. (type strain LMG 29315T = CCUG 68414T), Burkholderia turbans sp. nov. (type strain LMG 29316T = CCUG 68413T), Burkholderia catudaia sp. nov. (type strain LMG 29318T = CCUG 68411T) and Burkholderia peredens sp. nov. (type strain LMG 29314T = CCUG 68415T). Furthermore, we present emended descriptions of the species Burkholderia sordidicola, Burkholderia zhejiangensis and Burkholderia grimmiae. The GenBank/EMBL/DDBJ accession numbers for the 16S rRNA and gyrB gene sequences determined in this study are LT158612-LT158624 and LT158625-LT158641, respectively.

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Section: Discussionsupporting

confidence: 56%

Phylogenomic Study of Burkholderia glathei-like Organisms, Proposal of 13 Novel Burkholderia Species and Emended Descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae

et al. 2016

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“…Early reports of liver splits, especially in adults, led to concern for worse outcomes following use of a split liver graft, specifically with concern for higher complication rates . Since that time, the selective use of split liver transplants has been shown to have outcomes that parallel those of whole graft liver transplants . In a 2013 publication of our split liver transplantation experience by Doyle et al., we reported excellent outcomes for both adults and children receiving split liver grafts.…”

mentioning

confidence: 78%

“…[1][2][3][4][5] Since that time, the selective use of split liver transplants has been shown to have outcomes that parallel those of whole graft liver transplants. 6 In a 2013 publication of our split liver transplantation experience by Doyle et al, 7 we reported excellent outcomes for both adults and children receiving split liver grafts.…”

mentioning

confidence: 86%

Split liver grafts can benefit both pediatric and adult liver transplant recipients and programs

Dageforde

Chapman

2017

Pediatric Transplantation

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“…Bone marrow, heart, liver, and kidney transplantations are performed in many countries however, recently the transplantation field has progressed to islet cell and multi-visceral transplantations in some centers (Figures 2, 3). Due to the current demand of organ donors exceeding the number of transplantable organs, live donation (liver and kidneys), and split graft transplants (liver) have become a vital option (62).…”

Section: Organ Transplantationsmentioning

confidence: 99%

The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

Terry

2020

Front. Immunol.

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BACKGROUND OF REGULATORY T CELLS Naturally occurring CD4 + CD25 high regulatory T (Treg) cells maintain peripheral self-tolerance in rodents and humans (1, 2). In 1995, Sakaguchi and colleagues demonstrated that adoptive transfer of a subset of CD4 + T cells expressing the IL-2 receptor α-chain (CD25) prevented autoimmunity (1). CD4 + CD25 high T cells constitute 5 to 10% of CD4 + T cells in the blood (3) and they are able to maintain immunologic self-tolerance and transplantation tolerance by actively suppressing self-reactive, alloantigen-reactive lymphocytes. Treg cells prevent activation and expansion of auto-reactive T cells that escape clonal deletion in the thymus. Treg cell development and function is controlled by the transcription factor Foxp3, however defects can lead to autoimmune and inflammatory syndromes in humans and mice (4).

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Intention to Split Policy

Abstract: SLT is an effective surgical strategy to meet the demands in a combined adult and pediatric transplant center. Good outcomes can be achieved with a standardized technique.

Cited by 82 publications

References 37 publications

Phylogenomic Study of Burkholderia glathei-like Organisms, Proposal of 13 Novel Burkholderia Species and Emended Descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae

Phylogenomic Study of Burkholderia glathei-like Organisms, Proposal of 13 Novel Burkholderia Species and Emended Descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae

Split liver grafts can benefit both pediatric and adult liver transplant recipients and programs

The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

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