Intentional Toxic Ingestion of Sodium Fluoride: A Case Report

Abstract

Sodium fluoride is an accessible and frequently used compound that if ingested can cause ventricular dysrhythmias, hemorrhage, and death. We present a case report of a 21-year-old female who presented following an intentional ingestion of a lethal dose of sodium fluoride, developing massive hemorrhage and cardiac arrest.

Trastornos electrolíticos inducidos por fármacos y sustancias tóxicas

“…■ Fluoruro de sodio Es un compuesto en forma de polvo incoloro e inodoro que se ha usado como insecticida, y más comúnmente para la fluoración del agua y para hacer crema dental por su capacidad para fortalecer el esmalte dental. A dosis tóxicas produce hipocalcemia severa secundaria a la formación de fluorapatita, debido a que por cada anión fluoruro, se consumen 5 moléculas de calcio sérico en su forma ionizada [79].…”

Studying the Ameliorative Effect of Curcumin on the Pancreas, Immunity, and Oxidative Stress of Sodium Flouride Intoxicated Male Albino Rats

“…Worldwide, elevated fluoride levels in water used for drinking have been connected to potential health concerns (Demarchi et al, 2023). Easily found online as a 98% pure reagent, Sodium fluoride (NaF) is a colourless and odourless granules that finds applications as a DIY toothpaste, pesticide, and wheel cleaner (Bridwell et al, 2019). Fluoride binds with many proteins, specially the enzymes inhibiting their activity (Waugh, 2019).…”

Histological effects of chronic sodium fluoride toxicity on some reproductive organs of male and female adult albino rats

“…Fluoride is a natural element existing in the environment, prolonged exposure to fluoride (F) in air, soil and water, resulting in accumulation of these ions in the body by forming salts, mainly in the bones so that fluoride level above 3-6 mg/L may lead to skeletal fluorosis and in teeth, the level above 1.5 mg/L lead to dental fluorosis in both human beings and domestic animals (1,2). Fluoride has both useful and mischievous effects on public health; several studies indicate that fluoride in low concentration is fundamental for both man and animals especially for growth and development of teeth and bones (3) chronic exposure to fluoride have disruptive effects on various tissues of body like apoptosis, neurological disorder, gastrointestinal disturbances and reproductive system dysfunctions, hemorrhage and cardiac arrest (1,4). Multiple investigations refer to a relationship between long-dated fluoride exposure and impairment of fertility thus, various experimental on mice, rabbit, Guinea big and rats refers to adverse effects of sodium fluoride on the reproductive function of it (5,6) many researchers refer to modification in histological structures, reproductive hormone changes, fertility (7) and changes in organ body weight; the deleterious effects of sodium fluoride can be reduced by using different materials such as pomegranate seed oil (8), as well as the toxic effect of sodium nitrate can be reduced by ascorbic acid (9).…”