Intentional use of Schistosoma mansoni-infected grafts in living donor liver transplantation

Andraus, Wellington; Pugliese, Vincenzo; Pecora, Rafael A.; D’Albuquerque, Luiz Augusto Carneiro

doi:10.1002/lt.23436

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…In such cases, the presence of the parasite in the mesenteric veins of the recipient can be assumed, and therapy with praziquantel is indicated. However, if there are eggs in the periportal space of the donor’s liver, the disease is unlikely to be transmitted after liver transplantation, and neither significant incidence of acute or chronic rejection nor reduced long-term patient/graft survival has been observed 7 , 14 . In a 10-year follow-up of patients with schistosomiasis after undergoing kidney transplantation, parasitic infection did not interfere with patient survival and graft loss 15 .…”

Section: Discussionmentioning

confidence: 99%

Schistosomiasis of liver graft as a differential diagnosis of abnormal liver tests after transplantation: report of two cases

Falcão¹,

Batista²,

Maranhão³

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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Schistosomiasis is a major health problem that affects over 200 million people worldwide. There are few reports of Schistosoma mansoni found in liver transplants as well as scarce information about the course of the disease and the long-term effects on the graft. Herein, we report two cases of schistosomiasis in liver transplant recipients who presented abnormal serum liver enzymes, with evidence of gradual improvement after antiparasitic treatment. Furthermore, we discuss the possible role of screening the parasite infection in potential liver transplant recipients from endemic areas.

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Section: Discussionmentioning

confidence: 99%

Schistosomiasis of liver graft as a differential diagnosis of abnormal liver tests after transplantation: report of two cases

Falcão¹,

Batista²,

Maranhão³

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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“…7,8,[15][16][17] Nesse relato, foi observado, assim como em trabalhos anteriores, uma boa evolução da paciente que recebeu o enxerto com Schistosoma mansoni, 7,8,15-17 não sendo estabelecido de imediato tratamento com praziquantel, droga de escolha para o tratamento da esquistossomose, posto que essa droga geralmente não afeta os ovos e os vermes imaturos e atua apenas contra os vermes adultos. 18 Andraus et al 19 descreveram um transplante intencional utilizando enxerto de doador com esquistossomose, em um transplante intervivos, sem complicações, em dois anos de pós-operatório. Durante os primeiros estágios da doença, a função hepática é preservada e o paciente assintomático, 7 o que encoraja o uso de enxertos de doadores com Schistosoma mansoni em um contexto de limitação ao transplante, devido à escassez de doação de órgãos e ao uso de enxertos de doadores limítrofes.…”

Section: Discussionunclassified

Utilização De Enxerto Hepático Com Schistosoma Mansoni: Relato De Um Achado Inesperado

Neto

Parente

Rabêlo

et al. 2019

bjt

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Introdução: O aumento no número de transplantes realizados e o uso de enxertos de doadores limítrofes têm levado à identificação de agentes infecciosos, como o Schistosoma mansoni, em enxertos de doadores assintomáticos e que não eram diagnosticados antes do transplante. Dessa forma, o presente trabalho visa descrever o relato de caso de uma paciente que recebeu enxerto hepático com Schistosoma mansoni, não comprometendo o resultado do transplante hepático no pós-operatório mediato.

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“…To date, only 20 cases of transplanted liver grafts infested with C. sinensis (Table ) and 7 with S. mansoni have been reported in the literature . All the liver transplantations with grafts infested with C. sinensis (18 in adult and 2 in pediatric recipients) were performed in East Asian countries, 16 of which were deceased‐donor living transplantation and 5 LDLT.…”

Section: Discussionmentioning

confidence: 99%

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Capobianco¹,

Frank

Königsrainer³

et al. 2015

Transplant Infectious Dis

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Clonorchiasis is a cholangiopathy caused by foodborne trematode parasites, also known as liver flukes. Clonorchiasis is endemic in a wide geographical area extending from Eastern Europe to Southeast Asia. Infested hosts may remain asymptomatic for decades and consequently their liver can become available as a graft. To date, 20 liver transplantations with liver fluke-infested grafts have been reported in the literature. All of them occurred in Asian countries. We, here, report the first case to our knowledge in the Western world of living-donor liver transplantation (LDLT) with an Opisthorchis felineus-infested graft, and present a review of the literature. A 6-month-old girl with decompensated secondary biliary cirrhosis underwent an LDLT with a left lateral graft infested with O. felineus. After prompt diagnosis and adequate therapy, both donor and recipient had an uneventful postoperative course and long-term follow-up. Liver grafts infested with liver flukes do not pose a contraindication to liver donation from deceased or living donors, provided that a correct diagnosis and treatment are performed in a timely fashion.

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Intentional use of Schistosoma mansoni-infected grafts in living donor liver transplantation

Cited by 13 publications

References 8 publications

Schistosomiasis of liver graft as a differential diagnosis of abnormal liver tests after transplantation: report of two cases

Schistosomiasis of liver graft as a differential diagnosis of abnormal liver tests after transplantation: report of two cases

Utilização De Enxerto Hepático Com Schistosoma Mansoni: Relato De Um Achado Inesperado

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

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