Inter-alpha-trypsin inhibitor (ITI): A useful genetic system in paternity testing. Evidence for polymorphic occurrence ofITI*3 and existence of a new allele,ITI*4

Yuasa, Isao; Suenaga, Kazuyuki; Saneshige, Yukio; Tamaki, Nobuto; Ito, Keiichi; Okada, Kichiro

doi:10.1007/bf01369806

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…This simple mode of Mendelian inheritance has been confirmed by Luckenbach et al (1991), who have investigated the ITI polymorphism in formal genetic and linkage analysis. It has been shown that the ITI allele and phenotype frequency distribution is significantly different in European, Asian and African populations (Vogt et al a, 1992Yuasa et al 1991). The ITI system is, thus, a useful marker for population genetics and forensic studies.…”

Section: Introductionmentioning

confidence: 98%

The polymorphism of the plasma inter-α-trypsin inhibitor (ITI) and its relationship to the heavy chain H1 subunit gene (ITIH1) at 3p211-212

et al. 1994

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We investigated the ITI protein polymorphism in linkage analysis, using DraI and SstI as restriction fragment length polymorphism (RFLP) markers for the ITIH1 gene. Isoelectric focusing (IEF) classification from 76 individual plasma samples and RFLP analysis from the corresponding DNA preparations disclosed linkage disequilibrium between the phenotypic IEF patterns of the two common ITI alleles, ITI*1 and ITI*2, and the diallelic DNA polymorphisms of two ITIH1 RFLPs, represented by DraI 4.0 kb and DraI 2.4 + 1.6 kb, and by SstI 6.7 kb and SstI 6.0 + 0.7 kb, for the ITI 1 and ITI 2 IEF phenotypes, respectively, and by DraI 4.0/2.4 + 1.6 kb and SstI 6.7/6.0 + 0.7 kb for the heterozygous ITI 1-2 IEF phenotype. Linked segregation between either of the RFLPs and the polymorphic ITI plasma protein locus has been established in nine informative family pedigrees. The less frequent allele in Europeans, ITI*3, is not represented by a further allelic restriction fragment in either RFLP. The significant linkage disequilibrium observed in this genetic study indicates that the ITI locus, with the alleles ITI*1 and ITI*2, must be close to, or reside within, the ITIH1 gene. The diallelic ITI protein polymorphism therefore provides an informative phenotypic marker system for chromosome 3p211-212.

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Section: Introductionmentioning

confidence: 98%

The polymorphism of the plasma inter-α-trypsin inhibitor (ITI) and its relationship to the heavy chain H1 subunit gene (ITIH1) at 3p211-212

et al. 1994

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“…Restraction fragment length polymorphisms (RFLPs) of ITI genes were reported [3][4][5][6][7], and the ITI polymorphism of serum protein was first described by Vogt and Cleve [8]. The [8][9][10][11][12] and recently, Vogt et al [13] reported that ITI protein polymorphism may be controlled by the gene coding for the ITI heavy chain H1.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of the H1 subunit of inter-alpha-trypsin inhibitor

1995

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Inter-alpha-trypsin inhibitor (ITI) consists of 3 subunits (H1, H2 and L) which are encoded by 3 distinct genes. We attempted to prepare the subunit-specific monoclonal antibodies to identify the subunit carrying ITI polymorphism. Three monoclonal antibodies which were specific against each of these 3 subunits (ITI H1, ITI H2 and ITI L) were selected. ITI types could be detected by anti ITI H1 antibody, but not by anti ITI H2 or anti ITI L antibodies. From the result, it was proved that ITI polymorphism originates from the ITI H1 gene products, therefore we propose to call this system ITI H1 polymorphism.

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“…ITI is controlled by 3 common alleles ITI* 1, ITI*2 and ITI*3. Recently, additional alleles ITI*4, ITI*5 and ITI*6 have been reported [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Inter-alpha-trypsin inhibitor polymorphism

1994

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Serum samples treated with chondroitinase ABC and sialidase were investigated for the detection of inter-alpha-trypsin inhibitor (ITI) polymorphism. The improved phenotyping procedure has proved to be the most practical method for ITI phenotyping. The ITI allele frequencies were examined in 2 population samples from Japanese (n = 365) and Thais (n = 150). Three common alleles, ITI*1, ITI*2, and ITI*3 were identified in both populations, but the Thai population showed a higher frequency of ITI*1 and a lower frequency of ITI*3. Two new alleles were found, which were tentatively denoted ITI*Y and ITI*T. The ITI*T allele frequency in Thais was 0.047.

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Inter-alpha-trypsin inhibitor (ITI): A useful genetic system in paternity testing. Evidence for polymorphic occurrence ofITI3 and existence of a new allele,ITI4

Cited by 13 publications

References 12 publications

The polymorphism of the plasma inter-α-trypsin inhibitor (ITI) and its relationship to the heavy chain H1 subunit gene (ITIH1) at 3p211-212

The polymorphism of the plasma inter-α-trypsin inhibitor (ITI) and its relationship to the heavy chain H1 subunit gene (ITIH1) at 3p211-212

Genetic polymorphism of the H1 subunit of inter-alpha-trypsin inhibitor

Inter-alpha-trypsin inhibitor polymorphism

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