Hp typing and Tf, Gc and Pi subtypings were performed on 144 serum samples from a Nepalese population in the Katmandu Valley, Nepal. The obtained allele frequencies are as follows: Hp¹ = 0.1771, Hp² = 0.8229; Tf^C1 = 0.7222, Tf^C2 = 0.2500, Tf^C3 = 0.0174, Tf^Cnepal(Tf^C9) = 0.0104; Gc^1F= 0.2448, Gc^1S = 0.4825, Gc² = 0.2727; Pi^M1 = 0.6076, Pi^M2 = 0.2118, Pi^M3 = 0.1806. The relationship between this sample population and the Indian population is discussed.

The genetic polymorphism of human inter-alpha-trypsin inhibitor (ITI) has been investigated in sialidase-treated samples by isoelectric focusing on polyacrylamide gels with a pH range 3.5-9.5 followed by passive blotting with enzyme immunoassay. In 400 blood donors from western Japan, 8 simplified band patterns were observed, 6 of which could be explained by the previously described 3 polymorphic alleles, ITI*1, ITI*2, and ITI*3. The others were products of a new and rare fourth allele designated ITI*4, whose expression is also consistent with autosomal codominant inheritance. The frequency of these alleles was 0.440, 0.526, 0.030 and 0.004, respectively. The theoretical exclusion rate for putative fathers in paternity cases was calculated to be 0.228. The ITI system is a useful genetic marker for forensic hemogenetics in Japanese and in Europeans.

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The genetic polymorphism of transferrin (TF) was studied in 2,167 Japanese individuals and in 448 New Zealanders. The three TF C subtypes were identified, but TF C3 was absent from Japanese populations. In addition, three TF B and six TF D variants were observed, each of which occurred either in Japanese or in New Zealanders. Stepwise removal of N-acetyl-neuraminic acid (NANA) with neuraminidase revealed that the most cathodal variant TFD_shinnanyo found in a Japanese family was characterized by having only two NANA residues.

No abstract