Inter- and intra-individual sources of variation in levels of urinary styrene metabolites

Symanski, Elaine; Bergamaschi, Enrico; Mutti, Antonio

doi:10.1007/pl00007951

Cited by 33 publications

(12 citation statements)

References 32 publications

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“…Concentrations of urinary creatinine are frequently used to adjust the dilution of spot urine samples. We opted not to adjust for creatinine because, while correcting for dilution, it introduces inter-individual variation due to the fact that creatinine excretion rates are inXuenced by such factors as BMI, physical activity, diet and lean muscle mass (Symanski et al 2001;Viau et al 2004;Barr et al 2005). The levels of urinary 1-OHPG measured in the current study (range 0.04-3.27 ng/ml) were high compared to those we previously reported; mean levels in children (12-13 years) and their mothers (n = 300) ranged from 0.0158 § 0.0043 to 0.0645 § 0.0087 ng/ml among six diVerent regions in South Korea (Kang et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Lee

Vermeulen

Lenters

et al. 2008

Int Arch Occup Environ Health

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Section: Discussionmentioning

confidence: 99%

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Lee

Vermeulen

Lenters

et al. 2008

Int Arch Occup Environ Health

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“…An aliquot of urine was collected at the end of shift concomitantly with other samplings and used for the determination of the styrene-specific urinary metabolites MA, PGA, 4-VPT, and regioisomeric PHEMAs. The methodologies have been described previously for MA and PGA (Symanski et al 2001), for 4-VPT (Manini et al 2002), and for the PHEMAs diastereomeric N-acetyl-S-(1-phenyl-2-hydroxyethyl)-cysteine (M1RR), (M1RS), and N-acetyl-S-(2-phenyl-2-hydroxyethyl)-cysteine (M2) (Ghittori et al 1997).…”

Section: Methodsmentioning

confidence: 99%

Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers.

Vodička

Tuimala

Štětina

et al. 2004

Environ Health Perspect

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The effect of occupational exposure to styrene on frequencies of chromosomal aberrations and binucleated cells with micronuclei and on single-strand break levels in peripheral blood lymphocytes was studied in 86 reinforced plastic workers and 42 control individuals (including 16 maintenance workers with intermittent, low-dose exposure). In these individuals, the irradiationspecific DNA repair rates and the repair rates of 8-oxoguanines were investigated. We assessed the exposure by measuring the concentrations of styrene in air and in blood and of mandelic acid, phenylglyoxylic acid, 4-vinyl phenol conjugates and regioisomeric phenyl hydroxyethyl mercapturic acids in urine. All these parameters correlated with one another. No clear relationship was found between the styrene exposure and the frequencies of chromosomal aberrations. Binucleated cells with micronuclei were moderately related to the parameters of styrene exposure. We found a negative correlation between all exposure parameters and single-strand breaks. The positive correlation between exposure parameters and DNA repair rates suggests that particular DNA repair pathways may be induced by styrene exposure.

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“…Clayton et al (1999) evaluated correlations among pairs of longitudinal observations in the NHEXAS-Region 5 study and concluded that a single measurement provided a reasonable estimate of long-term exposure for some compounds (e.g., arsenic and lead in tap water) but not for others (e.g., VOCs in personal air). We followed the lead of others (Fleiss, 1986;Lemasters et al, 1996;Ryan et al, 2000;Symanski et al, 2001;Pang et al, 2002) in partitioning variance into between-and within-person components (Table 6) to evaluate the reliability of a single measurement with respect to a long-term average. The high intraclass correlation coefficient (r r ) of 0.76 for both lead in blood and chlorpyrifos in dust indicates that the observed variance was largely due to subject-specific differences and that measurements for a given individual were consistent over the study period of 1 year.…”

Section: Temporal Variability and Reliabilitymentioning

confidence: 99%

Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers

Egeghy

Quackenboss

Catlin

et al. 2004

J Expo Sci Environ Epidemiol

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The longitudinal NHEXAS-Maryland study measured metals, PAHs, and pesticides in several media to capture temporal variability. Questionnaires were concurrently administered to identify factors that influenced changes in contaminant levels over time. We constructed mixed-effects regression models for lead, phenanthrene, and chlorpyrifos (including metabolites) in indoor air, dust, dermal wipes, and biological fluids. Significant predictors represented time-varying activities as well as unchanging housing and demographic factors. There was little overlap among the models, with predictors generally reflecting the diverse characteristics of the target compounds. We estimated between-and within-person variance components to evaluate the reliability of the measurements. While only one measurement of lead in blood or chlopyrifos in dust was needed for a dependable estimate of an individual's average level, three to eight measurements were needed for most other compound/exposure medium combinations because of considerable temporal variability. Measurements in biological fluids and dust were generally more consistent than those in indoor air. The significant covariates in the full models preferentially reduced the between-person variance component. Since the regression models explained only 1-37% of the within-person variance, the questionnaires in this study provided only modest insight into the factors responsible for the temporal variability in the contaminant levels.

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Inter- and intra-individual sources of variation in levels of urinary styrene metabolites

Cited by 33 publications

References 32 publications

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers.

Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers

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