Inter-Hospital Escalation-of-Care Referrals for Severe Alcohol-Related Liver Disease with Recent Drinking During the COVID-19 Pandemic

Chen, Po-Hung; Ting, Peng–Sheng; Almazan, Erik; Chander, Geetanjali; Cameron, Andrew M.; Gürakar, Ahmet

doi:10.1093/alcalc/agab047

Cited by 21 publications

(24 citation statements)

References 14 publications

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“…The early surge of cirrhosis-related ALD mortality is consistent with prior reports of increased alcohol sales and use during the initial period of the pandemic and increased ALDassociated hospitalization. [10][11][12][13] Recent studies showed that alcohol abuse was independently associated with severe COVID-19 and COVID-19-related death. 14 Another recent study showed an increase in both COVID-19-related and non-COVID-19-related mortality of patients with ALD.…”

Section: Discussionmentioning

confidence: 99%

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

Yeo¹,

He²,

Lv³

et al. 2022

J Clin Transl Hepatol

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Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavirus disease 2019 (COVID-19) pandemic. A nationwide dataset that includes more than 99% of the decedents in the U.S. between April 2012 and September 2021 was used. Projected age-standardized mortality during the pandemic were estimated according to prepandemic mortality rates, stratified by season. Excess deaths were determined by estimating the difference between observed and projected mortality rates. A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was included. Following an increasing trend of cirrhosis-related mortality before the pandemic, with a semiannual percentage change (SAPC) of 0.54% [95% confidence interval (CI): (0.0-1.0%), p=0.036], a precipitous increase with seasonal variation occurred during the pandemic (SAPC 5.35, 95% CI: 1.9-8.9, p=0.005). Significantly increased mortality rates were observed in those with alcohol-associated liver disease (ALD), with a SAPC of 8.44 (95% CI: 4.3-12.8, p=0.001) during the pandemic. Allcause mortality of nonalcoholic fatty liver disease rose steadily across the entire study period with a SAPC of 6.79 (95% CI: 6.3-7.3, p<0.001). The decreasing trend of HCV-related mortality was reversed during the pandemic, while there was no significant change in HBV-related deaths. While there was significant increase in COVID-19-related deaths, more than 55% of the excess deaths were the indirect impact of the pandemic. We observed an alarming increase in cirrhosisrelated deaths during the pandemic especially for ALD, with evidence in both direct and indirect impact. Our findings have implications on formulating policies for patients with cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

Yeo¹,

He²,

Lv³

et al. 2022

J Clin Transl Hepatol

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“…Mounting evidence indicates that alcohol sales, alcohol consumption, and complications of alcohol use have increased during the pandemic. 1 , 2 , 3 However, there are limited data on nationwide alcohol use disorder (AUD)–related mortality. Here, we use projective modeling to evaluate AUD-related mortality rates in the US from 2012 to 2021, with a focus on trends during the COVID-19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Trends in Alcohol Use Disorder–Related Mortality in the US Before and During the COVID-19 Pandemic

Yeo

Ting

et al. 2022

JAMA Netw Open

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“…2 Likewise, another study documented self-reported increases in daily alcohol use. 3 Preliminary reports suggest an increase in hospital admissions for alcohol-related liver disease (ARLD), 4,5 but comparisons with prior years have not yet been documented. We investigated whether new hospital admissions resulting from ARLD increased in the summer of 2020 compared with previous years.…”

mentioning

confidence: 99%

Alcohol‐related hepatitis admissions increased 50% in the first months of the COVID‐19 pandemic in the USA

González

Zhou

Nimri

et al. 2022

Liver International

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Early reports suggest that alcohol misuse increased in 2020 as a result of the COVID-19 pandemic. Using retrospective data from Henry Ford Health System in Detroit MI-an area that experienced an early and severe COVID-19 outbreak-we investigated the impact of the pandemic on alcohol-related liver disease (ARLD) in the summer of 2020 compared with the same period in 2016-2019. Both the number of ARLD admissions and the proportion of total admissions represented by ARLD patients increased significantly in 2020 compared with previous years. The number of ARLD admissions as a proportion of all hospitalizations was 50% higher in 2020 than in 2016-2019 (0.31% vs 0.21%; P = .0013); by September 2020, the number of admissions was 66% higher than previous years. Despite racial and geographical disparities in direct and indirect COVID-related stressors across the Detroit metropolitan area, the demographic profile of ARLD patients did not change compared with previous years.

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Inter-Hospital Escalation-of-Care Referrals for Severe Alcohol-Related Liver Disease with Recent Drinking During the COVID-19 Pandemic

Cited by 21 publications

References 14 publications

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

Evaluation of Trends in Alcohol Use Disorder–Related Mortality in the US Before and During the COVID-19 Pandemic

Alcohol‐related hepatitis admissions increased 50% in the first months of the COVID‐19 pandemic in the USA

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