Inter-individual Variability in Response to Non-invasive Brain Stimulation Paradigms

López-Alonso, Virginia; Cheeran, Binith; Río-Rodríguez, Dan; Fernández-del-Olmo, Miguel

doi:10.1016/j.brs.2014.02.004

Cited by 693 publications

(605 citation statements)

References 37 publications

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“…We also offer recommendations for future studies that may help resolve these inconsistencies and shed more definitive light on the ability to use tES to enhance attention. As effects of tES on other domains also appear less robust than initially thought (e.g., Horvath et al 2015b;López-Alonso et al 2014, 2015Mancuso et al 2016), our recommendations may also be of value to tES researchers in fields other than attention.…”

Section: Discussionmentioning

confidence: 68%

“…Recent studies have shown that even the influence of stimulation on motor-evoked potentials-the primary proof of tDCS efficacy in humans-is subject to high inter- (López-Alonso et al 2014;Strube et al 2016;Wiethoff et al 2014) and intraindividual variability (Dyke et al 2016;Horvath et al 2015b;López-Alonso et al 2015). The ultimate solution may be to tailor stimulation dosage and placement of electrodes to individual brains, but this requires sophisticated computational modeling efforts that are only just getting under way (Berker et al 2013;Bikson et al 2012).…”

Section: Discussionmentioning

confidence: 99%

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Transcranial Electrical Stimulation as a Tool to Enhance Attention

et al. 2017

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Attention is a fundamental cognitive process-without it, we would be helplessly adrift in an overload of sensory input. There is considerable interest in techniques that can be used to enhance attention, including transcranial electrical stimulation (tES). We present an overview of 52 studies that have paired attention tasks with tES, mostly in the form of transcranial direct current stimulation (tDCS). In particular, we discuss four aspects of attention that have been most extensively targeted to date: visual search, spatial orienting (e.g., Posner cueing tasks), spatial bias (e.g., line bisection tasks), and sustained attention. Some promising results have been reported in each of these domains. However, drawing general conclusions about the efficacy of tES is at present hampered by a large diversity in study design and inconsistent findings. We highlight some pitfalls and opportunities and suggest how these may be addressed in future research aiming to use tES as a tool to enhance or test theoretical hypotheses about attention.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Transcranial Electrical Stimulation as a Tool to Enhance Attention

et al. 2017

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“…Recent studies on healthy participants have emphasised that the response to tDCS is highly variable between individuals (López- Alonso et al, 2014;Wiethoff et al, 2014). Several clinical trials involving participants with stroke have also reported highly variable responses (Hummel et al, 2005;Bolognini et al, 2011;Hesse et al, 2011;Khedr et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Triccas

Burridge

Hughes

et al. 2016

Clinical Neurophysiology

112

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h i g h l i g h t stDCS and rehabilitation had small non-significant effect on upper extremity impairments. Varied tDCS and rehabilitation programmes were identified in selected studies. Future research needs to further analyse tDCS and therapy interventions in stroke. a b s t r a c tObjective: To systematically review the methodology in particular treatment options and outcomes and the effect of multiple sessions of transcranial direct current stimulation (tDCS) with rehabilitation programmes for upper extremity recovery post stroke. Methods: A search was conducted for randomised controlled trials involving tDCS and rehabilitation for the upper extremity in stroke. Quality of included studies was analysed using the Modified Downs and Black form. The extent of, and effect of variation in treatment parameters such as anodal, cathodal and bi-hemispheric tDCS on upper extremity outcome measures of impairment and activity were analysed using meta-analysis. Results: Nine studies (371 participants with acute, sub-acute and chronic stroke) were included. Different methodologies of tDCS and upper extremity intervention, outcome measures and timing of assessments were identified. Real tDCS combined with rehabilitation had a small non-significant effect of +0.11 (p = 0.44) and +0.24 (p = 0.11) on upper extremity impairments and activities at post-intervention respectively. Conclusion: Various tDCS methods have been used in stroke rehabilitation. The evidence so far is not statistically significant, but is suggestive of, at best, a small beneficial effect on upper extremity impairment. Significance: Future research should focus on which patients and rehabilitation programmes are likely to respond to different tDCS regimes.

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“…The variations of current flow may also be associated with paradoxical stimulation effects, as represented by "cathodal stimulation" and suppressing performance by either anodal or cathodal stimulation (Filmer et al 2013). Moreover, a couple of recent reports suggest around half of healthy subjects do not show an expected excitatory effect on anodal tDCS (Lopez-Alonso et al 2014;Wiethoff et al 2014). Further, no persistent excitability changes during anodal, cathodal or sham stimulation have been reported, while polarity-independent after-effect was present (Santarnecchi et al 2014).…”

Section: Introductionmentioning

confidence: 95%

“…There has been a concept that the electrical current through the brain is believed to evoke depolarization of neurons and increasing excitability of the cortical region below the anodal electrode, with opposite effects on the cathodal electrode (Stagg et al 2013). However, controversy exists on this view (Lopez-Alonso et al 2014;Wiethoff et al 2014). Its excitatory effect remains up to 90 min (Nitsche and Paulus 2001), and daily repetitive stimulations elicit prolonged influences .…”

Section: Introductionmentioning

confidence: 99%

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Yokoi

Sumiyoshi

2015

Neuropsychiatr Electrophysiol

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Background: Growing attention is paid to transcranial direct current stimulation (tDCS) as a novel neuromodulation method in the treatment of psychiatric illnesses. In spite of its simple procedure, electrophysiological influence of tDCS is complex and not fully understood. Therefore, its procedure and clinical application is yet to be established. To address this issue, we reviewed and summarized reports currently available, and proposed future directions. Methods: We searched PubMed for the literature of tDCS, targeting depression, cognitive enhancement or schizophrenia, sham-controlled, and repeated stimulation sessions. Results: Among psychiatric conditions, depression is most associated with positive effects of tDCS, based on the recent systematic review, due to homogeneity in methodology adopted in randomized sham-controlled trials. For cognitive enhancement and/or treatment of schizophrenia, results are less consistent, and the methods are more heterogeneous. Conclusion: Large-scale well-designed trials are needed to more accurately evaluate the efficacy of tDCS. In this article, considerations of optimal stimulation conditions are also provided.

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Inter-individual Variability in Response to Non-invasive Brain Stimulation Paradigms

Cited by 693 publications

References 37 publications

Transcranial Electrical Stimulation as a Tool to Enhance Attention

Transcranial Electrical Stimulation as a Tool to Enhance Attention

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

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