Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)

Hariharan, Prasanna; Aycock, Kenneth I.; Buesen, Martin; Day, Steven W.; Good, Bryan C.; Herbertson, Luke H.; Steinseifer, Ulrich; Manning, Keefe B.; Craven, Brent A.; Malinauskas, Richard A.

doi:10.1007/s13239-018-00378-y

Cited by 37 publications

(27 citation statements)

References 27 publications

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“…The International Journal of Artificial Organs 44 (11) It should also be pointed out that this study only concerned the impact of turbulence models on the prediction of flow field. Blood damage such as hemolysis and thrombosis formation are more important issues for blood pumps.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

“…[6][7][8][9][10] Moreover, U. S. Food and Drug Administration (FDA) has plans to use computational simulations as part of its medical device approval process to fully evaluate the safety of medical devices. 11 In recent years, FDA launched the round robin initiative and designed two benchmarks, the "idealized medical device" and "blood pump," to evaluate and verify the accuracy of CFD simulation and prediction of blood damage, with both flow field and hemolysis were measured. 11,12 Overall, the CFD results were quite different from the experiment, while some of the predicted hemolysis levels were even several orders of magnitude different from the experimental values.…”

Section: Introductionmentioning

confidence: 99%

“…11 In recent years, FDA launched the round robin initiative and designed two benchmarks, the "idealized medical device" and "blood pump," to evaluate and verify the accuracy of CFD simulation and prediction of blood damage, with both flow field and hemolysis were measured. 11,12 Overall, the CFD results were quite different from the experiment, while some of the predicted hemolysis levels were even several orders of magnitude different from the experimental values. [13][14][15][16] One should note CFD is also the precondition for blood damage simulations, which provides inputs such as stress or strain rate.…”

Section: Introductionmentioning

confidence: 99%

“…The Reynolds number in the rotary blood pump is high (generally 100s of 1000s). 11 At Reynolds number increases, the boundary layer becomes decreasingly thinner, requiring excessively fine grids if inner-layer dynamics are to be correctly represented in wall-resolved LES. Chapman 31 estimated that the number of grid points required to resolve the wall-bounded flow is proportional to Re 1 8 .…”

Section: Introductionmentioning

confidence: 99%

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Large eddy simulation as a fast and accurate engineering approach for the simulation of rotary blood pumps

Huo

Zhang

et al. 2021

Int J Artif Organs

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An accurate representation of the flow field in blood pumps is important for the design and optimization of blood pumps. The primary turbulence modeling methods applied to blood pumps have been the Reynolds-averaged Navier–Stokes (RANS) or URANS (unsteady RANS) method. Large eddy simulation (LES) method has been introduced to simulate blood pumps. Nonetheless, LES has not been widely used to assist in the design and optimization of blood pumps to date due to its formidable computational cost. The purpose of this study is to explore the potential of the LES technique as a fast and accurate engineering approach for the simulation of rotary blood pumps. The performance of “Light LES” (using the same time and spatial resolutions as the URANS) and LES in two rotary blood pumps was evaluated by comparing the results with the URANS and extensive experimental results. This study showed that the results of both “Light LES” and LES are superior to URANS, in terms of both performance curves and key flow features. URANS could not predict the flow separation and recirculation in diffusers for both pumps. In contrast, LES is superior to URANS in capturing these flows, performing well for both design and off-design conditions. The differences between the “Light LES” and LES results were relatively small. This study shows that with less computational cost than URANS, “Light LES” can be considered as a cost-effective engineering approach to assist in the design and optimization of rotary blood pumps.

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Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Large eddy simulation as a fast and accurate engineering approach for the simulation of rotary blood pumps

Huo

Zhang

et al. 2021

Int J Artif Organs

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“…Returning to the theme of inter-laboratory comparisons, our special issue includes three papers arising from the FDA's Critical Path Initiative for CFD. The first paper, by Hariharan et al, 20 focuses on a centrifugal blood pump model developed by the FDA for the ultimate purpose of validating CFD predictions of hemolysis in medical devices. Here the authors report the results of a round-robin comparison of particle imaging velocity (PIV) measurements, since PIV will, ultimately, serve as the reference standard against which CFD velocity predictions must be validated.…”

mentioning

confidence: 99%