Large eddy simulation as a fast and accurate engineering approach for the simulation of rotary blood pumps

Huo, Jia‐Dong; Wu, Peng; Zhang, Liudi; Wu, Wei‐Tao

doi:10.1177/03913988211041636

Cited by 11 publications

(11 citation statements)

References 38 publications

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“…As for the ability of CFD to capture the flow field of blood pumps, we would like to mention our previous study, 19 which explored the feasibility of the LES technique as an engineering tool for the development, optimization, and assessment of blood pumps. FDA benchmark pump and HeartMate II blood pumps were studied using RANS and LES.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18] Low dissipation and high accuracy are the characteristics of LES, and the sensitivity to the grid was found to be considerably higher than that of URANS. Huo et al 19 employed both the LES and RANS to investigate the flow field in the FDA pump using three grids of 4.2, 8.3, and 19.5 million, respectively. The velocity profiles at the critical location of the outlet diffuser were compared.…”

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confidence: 99%

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The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

Huo

Zhang

et al. 2022

Artificial Organs

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Background Computational fluid dynamics has been widely used to assist the design and evaluation of blood pumps. Discretization errors associated with computational grid may influence the credibility of numerical simulations. Non‐conformal grid interfaces commonly exist in rotary machines, including rotary blood pumps. Should grid size across the interface differ greatly, large errors may occur. Methods This study explored the effects of non‐conformal grid interface on the prediction of the flow field and hemolysis in blood pumps using large eddy simulation (LES). Two benchmarks, a nozzle model and a centrifugal blood pump were chosen as test cases. Results This study found that non‐conformal grid interfaces with considerable change of grid sizes led to discontinuities of flow variables and brought errors to metrics such as pressure head (7%) and hemolysis (up to 14%). Conclusions The results on the full unstructured grid are more accurate with negligible changes of flow variables across the non‐conformal grid interface. A full unstructured grid should be employed for centrifugal blood pumps to minimize the influence of non‐conformal grid interfaces for LES simulations.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

Huo

Zhang

et al. 2022

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“…Nonetheless, the computational cost of DNS is prohibitive. Thus, to reduce computational cost, turbulence models such as Reynolds-averaged Navier-Stokes (RANS) (Li et al 2018;Wu et al 2019;Wu et al 2021) and recently, large eddy simulation (LES) (Huo et al 2021;Wu et al2011;Xiang et al 2023), are commonly applied to blood pumps. Turbulence modeling techniques model small-scale motions while resolve large-scale motions.…”

Section: Introductionmentioning

confidence: 99%

“…Turbulence modeling technique is one of the crucial factors which affects the prediction of stress and hemolysis (Blocken 2018;Heinz 2020). RANS is known for its deficiency for capturing circulation and separation flows which are commonly exist in blood pumps, leading to an inaccurate prediction of pump performance such as pressure head (Huo et al 2021). LES is superior in capturing these flows, performing well for both design and off-design conditions.…”

Section: Introductionmentioning

confidence: 99%

Grid convergence study for the prediction of hemolysis in blood circulatory devices: sensitivity to the form of equivalent stress and turbulence simulation methods

Zhang¹,

Wu²

2023

Preprint

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Hemolysis and related complications induced by non-physiological stress are major concerns during the development and clinical applications of blood circulatory devices. Turbulence is one of the primary causes of hemolysis. To consider turbulence effects on hemolysis, various turbulence simulation methods and stress forms were employed or proposed. Nonetheless, the results showed significant divergence for different stress forms and turbulence simulation methods, discrediting hemolysis prediction as an important tool for the design, optimization and evaluation of blood circulatory devices. This study aims at quantitatively investigating the grid convergence for the prediction of hemolysis in blood circulatory devices, with a focus on its sensitivity to the stress forms and turbulence simulation methods. We revealed the integral of equivalent stress has very different characteristics of grid convergence. For Reynolds-averaged Navier-Stokes (RANS) method, grid convergence was less demanding on grid size and insensitive to stress forms. For large eddy simulation (LES), grid convergence was demanding and sensitive to stress forms, with highest uncertainty for the “total scalar stress”, followed by “viscous stress”. The “energy-dissipation stress” showed the best grid convergence for both RANS and LES. We also observed a significant divergence for metrics based on “total scalar stress” under different turbulence simulation methods, while the “energy-dissipation stress” showed a much higher consistency. We show the combination of energy-dissipation stress and LES can better capture the trend of hemolysis and has the best grid convergence. This study provides insights for a better prediction of hemolysis in turbulent flows in blood circulatory devices.

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“…Hemodynamics play an important role in the initiation, formation, and aggregation of thrombosis ( Jama et al, 2011 ; Skorczewski et al, 2013 ; Liang et al, 2015 ). In recent years, computational fluid dynamics (CFD) studies have been employed to study hemodynamics ( Wu et al, 2020 , 2021 , 2022 ; Huo et al, 2021 ) and evaluate risk of thrombosis in abdominal aortic aneurysm, atrial appendages, aortic dissection, etc. ( Georgakarakos et al, 2009 ; Menichini et al, 2017 ; Bosi et al, 2018 ; García-Isla., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model

et al. 2022

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Objective: The aim of this study is to numerically evaluate thrombosis risk within occluded coronary arterial fistulas (CAF) with terminal aneurysms, and provide guidance in choosing occlusion positions, with clinical observations as reference.Method: Four patients with CAF were studied, with different occlusion positions in actual treatments. Hemodynamics simulations were conducted, with blood residue predicted using the blood stasis model. Three types of models (untreated model, aneurysm-reserved model and aneurysm-removed model) were studeid for each patient. Four metrics, i.e., proportion of high oscillatory shear index (OSI), area of high OSI, old blood volume fraction (OBVF)) and old blood volume (OBV) was obtained to distinguish the thrombosis risk of different treatments (proximal or distal occlusion), comparing with the follow-up CTA.Results: For all the postopertive models, the high OBVF, high OSI(>0.3) and low time-averaged wall shear stress (TAWSS) regions were mainly at the distal fistula, indicating these regions were prone to thrombosis. The regions where blood residue remains are roughly regions of high OSI, corresponding well with clinical observations. In contrast, TAWSS failed to distinguish the difference in thrombosis risk. Absolute values (area of high OSI, OBV) can better reflect the degree of thrombosis risk between treatment types compared with percentage values (proportion of high OSI, OBVF). By comparing with the actual clinical treatments and observations, the OBV is superior to the area of high OSI in determining treatment type.Conclusion: The OBV, a volumetric parameter for blood stasis, can better account for the CAF thrombosis and reflect the degree of blood stasis compared with OSI or TAWSS, is a more appropriate metric for thrombosis in the fistula. Together with morphological parameters, the OBV could guide clinicians to formulate more appropriate surgical plans, which is of great significance for the preoperative evaluation and treatment prognosis of CAF patients.

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Large eddy simulation as a fast and accurate engineering approach for the simulation of rotary blood pumps

Cited by 11 publications

References 38 publications

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

The influence of non‐conformal grid interfaces on the results of large eddy simulation of centrifugal blood pumps

Grid convergence study for the prediction of hemolysis in blood circulatory devices: sensitivity to the form of equivalent stress and turbulence simulation methods

A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model

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