Inter-vendor reproducibility and accuracy of segmental left ventricular strain measurements using CMR feature tracking

Dobrovie, Monica; Barreiro-Pérez, Manuel; Curione, Davide; Symons, Rolf; Claus, Piet; Voigt, Jens‐Uwe; Bogaert, Jan

doi:10.1007/s00330-019-06315-4

Cited by 50 publications

(44 citation statements)

References 22 publications

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“…Recently, a novel technique, cardiac magnetic resonance feature-tracking (CMR-FT), has been regarded as a more sensitive tool for measuring myocardial deformation as an indicator of subclinical myocardial dysfunction [7]. CMR-FT has been increasingly used for myocardial strain evaluation in various types of cardiomyopathy, such as cardiac amyloidosis [8], hypertrophic cardiomyopathy [9], and dilated cardiomyopathy [10], and the reproducibility of CMR-FT has been well demonstrated [11]. However, analyses of the role of LA and RV deformation in DCM by CMR-FT, especially with coexisting hypertension, have rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Shao

Cao

Cui

et al. 2020

BMC Cardiovasc Disord

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Background: Previous studies have found that impaired global myocardial systolic strain is associated with cardiovascular events in T2DM patients. However, the effect of hypertension (HT) on left atrial (LA), right ventricular (RV) and left ventricular (LV) myocardial deformation in hypertensive T2DM patients has not been fully studied by cardiac magnetic resonance feature tracking (CMR-FT). Our aim was to assess LA, RV and LV strain in T2DM patients with T2DM-HT and without hypertension using CMR-FT and to determine the underlying relationships with clinical parameters. Methods: A total of 27 T2DM patients, 23 T2DM-HT patients and 31 controls were studied. LA, LV and RV strain was evaluated using CMR-FT. The clinical and biochemical parameters of the patients were collected. Results: The T2DM patients had reduced LA global circumferential strain (LAGCS), radial strain (LAGRS), longitudinal strain (LAGLS) and right ventricular longitudinal strain (RVGLS) compared with the controls (LAGCS: 27.2 ± 2.1% vs 33.5 ± 2.4%; LAGRS:

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Section: Introductionmentioning

confidence: 99%

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Shao

Cao

Cui

et al. 2020

BMC Cardiovasc Disord

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“…Until now, only few studies examined segmental strain in patients with infarction [25,26], possibly because reduced accuracy and reproducibility of segmental strain values was reported for optical ow-based FT methods in the past [27]. The FT software used in this study is based on a non-rigid algorithm for image registration and segmentation and showed higher reliability and interobserver agreement in segmental strain than software based on optical ow methods [21,22]. In line with current study results, GPLS, GPCS and GPRS was reduced in our patient cohort compared to healthy controls [30].…”

Section: Discussionmentioning

confidence: 97%

“…Myocardial feature tracking (FT) was introduced for myocardial strain quanti cation using routinely acquired steady-state free precession (SSFP) cine sequences as input [9,[17][18][19]. Based on optical ow methods [20] or non-rigid algorithm for image registration and segmentation [21,22], myocardial borders can be identi ed and displacement of myocardial segments can be tracked throughout the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

“…Until now, only few studies examined segmental strain in patients with infarction [25,26], probably because reduced accuracy and reproducibility of segmental strain values was reported for optical ow-based FT methods [27]. FT software based on non-rigid algorithm for image registration and segmentation revealed higher accuracy and better reproducibility in segmental strain [21,22] and therefore can be potentially used for scar detection in cine images with su cient discrimination between remote and infarcted myocardium. The purpose of this study was to examine global and segmental strain values in patients with chronic infarcts and healthy controls and to investigate the feasibility of using segmental strain for scar detection in non-contrast cine images.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Segmental Strain for the Detection of Chronic Ischemic Scars in Non-Contrast Cardiac MRI Cine Images: A Feasibility Study

Polacin¹,

Károlyi²,

Eberhard³

et al. 2020

Preprint

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Aims Cardiac magnetic resonance imaging (MRI) with late gadolinium enhancement (LGE) is considered the gold standard for scar detection after myocardial infarction. In times of increasing skepticism about gadolinium depositions in brain tissue and contraindications of gadolinium administration in some patient groups, tissue strain-based techniques for detecting ischemic scars should be further developed as part of clinical protocols. Therefore, the objective of the present work was to investigate the feasibility of scar detection in segmental strain calculations based on routinely acquired non-contrast cine images in patients with chronic infarcts.Methods Forty-six patients with chronic infarcts and scar tissue in LGE images (5 female, mean age 52 ± 19 years) and 24 gender- and age- matched healthy controls (2 female, mean age 47 ± 13 years) were included. Global (global peak circumferential [GPCS], global peak longitudinal [GPLS], global peak radial strain [GPRS]) and segmental (segmental peak circumferential [SPCS], segmental peak longitudinal [SPLS], segmental peak radial strain [SPRS]) strain parameters were calculated from standard balanced SSFP cine sequences using commercially available software (Segment CMR, Medviso, Sweden). Two independent blinded readers localized potentially infarcted segments in segmental circumferential strain calculations (endo-/epicardially contoured short axis cine and resulting polar plot strain map) and by visual wall motion assessment of cine images. Results Global strain values were reduced in patients compared to controls (GPCS p= 0.02; GPLS p= 0.04; GPRS p= 0.01). Patients with preserved ejection fraction showed also reduced GPCS compared to healthy individuals (p=0.04). In patients, mean SPCS was significantly impaired in subendocardially (- 5,4% +/- 2) and in transmurally infarcted segments (- 1,2% ± 3) compared to remote myocardium (-12,9% +/- 3, p= 0.02 and 0.03, respectively). ROC analysis revealed an optimal cut- off value for SPCS for discriminating infarcted from remote myocardium of - 7,2 % with a sensitivity of 89,4 % and specificity of 85,7%. Mean SPRS was impeded in transmurally infarcted segments (15,9 % +/- 6) compared to SPRS of remote myocardium (31,4% +/- 5; p= 0.02). The optimal cut-off value for SPRS for discriminating scar tissue from remote myocardium was 16,6% with a sensitivity of 83,3% and specificity of 76,5%. 80.3 % of all in LGE infarcted segments (118/147) were correctly localized in segmental circumferential strain calculations based on non-contrast cine images compared to 53.7% (79/147) of infarcted segments detected by visual wall motion assessment (p > 0.01). Conclusion Global strain parameters are impaired in patients with chronic infarcts compared to healthy individuals. Mean SPCS and SPRS in scar tissue is impeded compared to remote myocardium in infarcts patients. Blinded to LGE images, two readers correctly localized 80% of infarcted segments in segmental circumferential strain calculations based on non-contrast cine images, in contrast to only 54% of infarcted segments detected by visual wall motion assessment. Analysis of segmental circumferential strain shows a promising alternative for scar detection based on routinely acquired, non-contrast cine images for patients who cannot receive or decline gadolinium.

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“…We used feature-tracking software (2D-Cardiac Performance global and regional longitudinal strain for both ventricles. The software uses optical flow technology (Dobrovie et al, 2019) and calculated GLS by averaging the values of six segments in the LV and in the respectively, obtained in the 4CH view. Because it is at times conceptually difficult to grasp negative strain values, we used absolute numbers to describe longitudinal RV strain, denoting −22% longitudinal strain as a "greater" strain value than −20% longitudinal strain, according to the EACVI consensus document regarding standardized deformation imaging (Voigt et al, 2015).…”

Section: Cmr Acquisition Protocol and Analysismentioning

confidence: 99%

Three‐dimensional echocardiography to identify right ventricular dilatation in patients with corrected Fallot anomaly or pulmonary stenosis

Trzebiatowska-Krzynska

Swahn

Wallby

et al. 2020

Clin Physio Funct Imaging

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Background 3‐Dimensional Echocardiography allows measuring volumes and parameters of myocardial deformation (strain). Myocardial strain has been suggested to be superior to conventional echo parameters in the assessment of right ventricular (RV) function. Myocardial strain can be assessed by cardiac magnetic resonance (CMR) or two‐ and three‐dimensional echocardiography (2D and 3DEcho). We performed a comprehensive assessment of the RV based on 3DEcho and compared the results with those based on CMR and 2DEcho. Methods 36 patients with corrected heart defects underwent CMR and 3DEcho to assess RV volume, strain and cardio pulmonary exercise testing with peak VO2 measurement. 2DEcho was used for reference. Results There was a moderate correlation between 3DEcho and CMR for measuring RV end‐diastolic and end‐systolic volumes (r = .82 and .72). 3DEcho tended to underestimate the RV volumes, mean difference EDV 8.5 ± 33 ml (CI −2.8; 19.7 ml) and ESV 13.2 ± 29 ml (CI 3.3; 23 ml). According to method‐specific reference values for RVEDV, 34/35 (3DEcho) and 29/36 (CMR) were dilated. Among those dilated according to CMR, all were identified by 3DEcho. The coefficient of correlation between RV atrioventricular plane displacement measured by CMR and tricuspid annular plane systolic excursion measured by 3D and 2DEcho was r = .6 for both. 2DEcho measured lower LV volumes than CMR. LVEF and GLS were similar in 2DEcho, 3DEcho and CMR. Patients with CMR‐determined RV free wall strain ≤ −14% tended to have lower peak VO2. Conclusions Although 3DEcho underestimated RV volumes, it successfully identified all patients with RV dilatation based on method‐specific reference values.

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Inter-vendor reproducibility and accuracy of segmental left ventricular strain measurements using CMR feature tracking

Cited by 50 publications

References 22 publications

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Analysis of Segmental Strain for the Detection of Chronic Ischemic Scars in Non-Contrast Cardiac MRI Cine Images: A Feasibility Study

Three‐dimensional echocardiography to identify right ventricular dilatation in patients with corrected Fallot anomaly or pulmonary stenosis

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