Interacting epidemics? Sleep curtailment, insulin resistance, and obesity

Lucassen, Eliane A.; Rother, Kristina I.; Cizza, Giovanni

doi:10.1111/j.1749-6632.2012.06655.x

Cited by 170 publications

(208 citation statements)

References 170 publications

(335 reference statements)

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“…[10,11] By contrast, sleep dysfunction is linked to the development of physical and psychological issues including cardiovascular problems, diabetes, obesity, anxiety, and all-cause high rates of death [12] and number of studies have supported that the metabolic rate related to interference of normal sleep behaviors may related to the development of obesity, cardiovascular disease, diabetes, and diabetes. [13][14][15][16][17][18][19][20][21][22][23][24][25][26] In the current study, the authors applied crosssectional study that explore the association between Body Mass Index (BMI) and sleep pattern among undergraduate female students of health colleges in Qassim University.…”

Section: Introductionmentioning

confidence: 99%

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

Alfarhan¹,

Matrouk²,

AlGaowba³

et al. 2018

JNEP

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Background and objective: Better quality and adequate amount of sleep are essential to have better cognitive performance and by contrast, poor bedrest is related to a diminishing of cognitive and psychological functioning and deteriorating physical health. Recently the quality of sleep among various segments of the population has become a focus of continuous research and investigations, where insufficient sleep may lead to adverse cardio-metabolic effects by influencing body weight, blood pressure, and glucose tolerance. The objective of this study is to explore the associations between sleep patterns and Body Mass Index (BMI) among undergraduate female students in health colleges. Methods: Across-sectional study was utilized among 288 of undergraduate female students who represent 30% of all undergraduate students in health Colleges of female section, Qassim University. The data regarding their sleeping pattern was collected and calculated by using a validated self-report questioner (Pittsburgh Sleep Quality Index) and Body Mass. Results: According to PSQI scoring, both categories good and poor sleep maximum according to PSQI scoring; both categories good sleep and poor sleep maximum participant's BMI was normal but no statistically significant association was seen between BMI of poor sleep was higher in overweight and obese participants from all departments and also no statistically significant association was seen between poor sleep and body mass index of participant As for the sleep quality as a single question and sleep duration in relation to BMI for different specialties, only for nursing students there was a statistically significant difference of sleep quality/duration in relation to their BMI. Conclusions: Frequency of poor sleep was higher in overweight and obese participants but as per findings there was no statistically significant association was detected between PSQI score and BMI of participants.

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Section: Introductionmentioning

confidence: 99%

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

Alfarhan¹,

Matrouk²,

AlGaowba³

et al. 2018

JNEP

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“…27,28 Los mecanismos biológicos y conductuales planteados para explicar la ganancia de peso y las alteraciones metabólicas inducidas por el acortamiento de la duración del sueño son el aumento del apetito por hipersecreción de grelina (hormona orexigénica) e hiposecreción de leptina (hormona anorexigénica), descenso del gasto energético, mayor oportunidad de comer durante la noche, ingesta de dietas de baja calidad nutricional y reducción de la actividad física por el cansancio que provoca la vigilia sostenida. 5,29 La hiperactividad del sistema nervioso simpático y la hipercortisolemia contribuiría a la insulinorresistencia asociada a la disminución del sueño. 5 Se recomienda que los entes de salud y educación desarrollen campañas educativas entre adolescentes y padres sobre el papel del sueño en el mantenimiento de una buena salud cardiometabólica.…”

Section: Discussionunclassified

“…5,29 La hiperactividad del sistema nervioso simpático y la hipercortisolemia contribuiría a la insulinorresistencia asociada a la disminución del sueño. 5 Se recomienda que los entes de salud y educación desarrollen campañas educativas entre adolescentes y padres sobre el papel del sueño en el mantenimiento de una buena salud cardiometabólica. Asimismo, se sugiere la ejecución de nuevas investigaciones de tipo longitudinal con un mayor tamaño muestral, que incluyan otras variables (estrato socioeconómico, dieta y formas de recreación).…”

Section: Discussionunclassified

“…2,3 E l s u e ñ o e s u n p r o c e s o restaurativo modulador de la función neuroendócrina y del metabolismo. 4 De allí que la disminución de la duración del sueño puede conducir a la desregulación metabólica y hormonal, que favorece la ingesta de alimentos, 5 la obesidad y el riesgo cardiometabólico. Una revisión sistemática y metaanálisis de estudios en adolescentes indicó una asociación inversa entre duración de sueño y obesidad, aunque algunos trabajos no han evidenciado tal hallazgo entre las mujeres jóvenes.…”

Section: Introductionunclassified

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Relación entre el déficit de sueño nocturno, el exceso de peso y las alteraciones metabólicas en adolescentes

et al. 2014

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“…Insulin resistance is also a risk factor for developing non-cardiovascular diseases, including cancer and kidney dysfunction [109]. More than one-third of the population in the United States is currently obese, and the same proportion of Americans have prediabetic levels of glycosylated haemoglobin (HbA1c) [110]; thus, the identification of shift work as an additional risk factor for developing these metabolic complications is highly relevant to a large number of individuals. In addition, shift work is associated with an increased risk of breast cancer [111], osteoporosis [112] and bone fractures [113].…”

Section: Implications For Societymentioning

confidence: 99%

Plasticity of circadian clocks and consequences for metabolism

Coomans

Lucassen

Kooijman

et al. 2015

Diabetes Obesity Metabolism

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The increased prevalence of metabolic disorders and obesity in modern society, together with the widespread use of artificial light at night, have led researchers to investigate whether altered patterns of light exposure contribute to metabolic disorders. This article discusses the experimental evidence that perturbed environmental cycles induce rhythm disorders in the circadian system, thus leading to metabolic disorders. This notion is generally supported by animal studies. Distorted environmental cycles, including continuous exposure to light, affect the neuronal organization of the central circadian pacemaker in the suprachiasmatic nucleus (SCN), its waveform and amplitude of the rhythm in electrical activity. Moreover, repeated exposure to a shifted light cycle or the application of dim light at night are environmental cues that cause a change in SCN function. The effects on the SCN waveform are the result of changes in synchronization among the SCN's neuronal cell population, which lead consistently to metabolic disturbances. Furthermore, we discuss the effects of sleep deprivation and the time of feeding on metabolism, as these factors are associated with exposure to disturbed environmental cycles. Finally, we suggest that these experimental studies reveal a causal relationship between the rhythm disorders and the metabolic disorders observed in epidemiological studies performed in humans. Keywords: circadian, desynchronization, suprachiasmatic nucleus, metabolic disorders, light Date submitted 11 April 2015; date of final acceptance 17 May 2015 Environmental Effects on the Rhythm of the SCNPerturbations in the circadian rhythm can develop under a variety of conditions, including ageing, neurodegenerative diseases and metabolic disorders. In order to effectively treat these diseases, it is important to elucidate the causal relationships behind these associations. Towards that end, several animal models have been used to specifically address the relationship between circadian disorders and metabolic disturbances. These models include transgenic mouse models with specific mutations in clock genes, as well as animals in which the function of the suprachiasmatic nucleus (SCN) has been altered by manipulating environmental cues. Transgenic models have been particularly valuable for elucidating the signalling pathways involved in the pathogenesis of metabolic disorders such as diabetes and obesity [1]. Moreover, performing complementary studies in wild-type animals and studying the effect of the environment on SCN functions are valuable as well, given the growing body of evidence suggesting that improper circadian timing interferes with health. For example, sleep disruption in humans is correlated with an increased risk of developing diabetes, and shift work has been associated with increased body mass index (BMI), altered plasma lipids and impaired insulin sensitivity [2][3][4] (Table 1). These studies indicate a potentially large influence of stable, robust environmental light-dark cycles on the maintenance o...

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Interacting epidemics? Sleep curtailment, insulin resistance, and obesity

Cited by 170 publications

References 170 publications

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

Relación entre el déficit de sueño nocturno, el exceso de peso y las alteraciones metabólicas en adolescentes

Plasticity of circadian clocks and consequences for metabolism

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