Interaction Between 2′,4-Dihydroxychalcone and the N, F, E Conformers of Bovine Serum Albumin: Influence of Temperature and Ionic Strength

Curvale, Rolando A.; Debattista, Nora B.; Pappano, Nora B.

doi:10.1007/s10930-012-9404-y

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Bearing in mind that the BSA molecule is hydrated, the first stage of the interaction is necessarily hydrophobic. 30 The second step, of BSA association, includes ionic interactions, hydrogen bonds, and hydrophobic interactions. Considering that iAs V provides ionic ligands, while iAs, III a physiological pH, is as a nondissociated species (H 3 AsO 3 ) with dipolar moment, it may be concluded that:…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometric study of the interaction between arsenic and bovine serum albumin

Curvale¹,

Debattista²,

Pappano³

et al. 2015

RRB

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Argentina is one of the countries that are most widely affected by chronic endemic regional hydroarsenicism, a syndrome caused by the constant consumption of water polluted with arsenic at higher levels. In this study, the interaction of bovine serum albumin with arsenite and arsenate was analyzed employing UV-Vis spectroscopy, considering its low cost and greater availability. The number of binding sites, binding constants, and thermodynamic parameters-∆G°, ∆H°, and ∆S°-were determined. The results obtained indicate that the interaction of bovine serum albumin with arsenate is ionic, while that with arsenite is hydrophobic.

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Section: Resultsmentioning

confidence: 99%

Spectrophotometric study of the interaction between arsenic and bovine serum albumin

Curvale¹,

Debattista²,

Pappano³

et al. 2015

RRB

View full text Add to dashboard Cite

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Flavonoid–membrane interactions: Involvement of flavonoid–metal complexes in raft signaling

Tarahovsky

Kim

Yagolnik

et al. 2014

Biochimica et Biophysica Acta (BBA) - Biomembranes

161

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Flavonoids are polyphenolic compounds produced by plants and delivered to the human body through food. Although the epidemiological analyses of large human populations did not reveal a simple correlation between flavonoid consumption and health, laboratory investigations and clinical trials clearly demonstrate the effectiveness of flavonoids in the prevention of cardiovascular, carcinogenic, neurodegenerative and immune diseases, as well as other diseases. At present, the abilities of flavonoids in the regulation of cell metabolism, gene expression, and protection against oxidative stress are well-known, although certain biophysical aspects of their functioning are not yet clear. Most flavonoids are poorly soluble in water and, similar to lipophilic compounds, have a tendency to accumulate in biological membranes, particularly in lipid rafts, where they can interact with different receptors and signal transducers and influence their functioning through modulation of the lipid-phase behavior. In this study, we discuss the enhancement in the lipophilicity and antioxidative activity of flavonoids after their complexation with transient metal cations. We hypothesize that flavonoid-metal complexes are involved in the formation of molecular assemblies due to the facilitation of membrane adhesion and fusion, protein-protein and protein-membrane binding, and other processes responsible for the regulation of cell metabolism and protection against environmental hazards.

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Interaction Between 2′,4-Dihydroxychalcone and the N, F, E Conformers of Bovine Serum Albumin: Influence of Temperature and Ionic Strength

Cited by 2 publications

References 34 publications

Spectrophotometric study of the interaction between arsenic and bovine serum albumin

Spectrophotometric study of the interaction between arsenic and bovine serum albumin

Flavonoid–membrane interactions: Involvement of flavonoid–metal complexes in raft signaling

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