Interaction between antidepressant drug and anionic surfactant in low concentration range in aqueous/salt/urea solution: A conductometric and fluorometric study

Mixtures of antidepressant amphiphilic drug imipramine hydrochloride and anionic surfactant: Micellar and thermodynamic investigation

“…The cmc value of IMH was obtained to be 38.75 mmol kg −1 in aqueous solution at 293.15 K in pure form showing a good agreement with previously accounted value . The cmc of value of pure NaDS and NaDBS were also found to be in well agreement with the earlier reported value . The occurrence of benzene ring in NaDBS increasing their hydrophobicity is the reason that NaDBS has lower cmc value in comparison with NaDS.…”

“…The ∆ G o m value of pure drug (IMH) was found to be the same as the previously accounted value . The values of in case of surfactants are also found in good conformity with the formerly reported value . The value achieved for surfactants (NaDS/NaDBS) is above the value of of IMH.…”

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

“…In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ). In spite of many reports on the interactions between drugs and conventional surfactants in the literature (Azum et al, , ; Cai et al, ; Chauhan et al, ; Enache and Volanschi, ; Hanif et al, ; Hossain and Hoque, ; Kabir‐ud‐Din et al, ; Kaushal et al, ; Khan et al, ; Khan and Shah, ; Lazaro et al, ; Mukhija and Kishore, ; Naqvi et al, ; Noori et al, ; Rub et al, , , ; Sharma and Jani, ; Ullah et al, ), there is limited number of studies that combine spectroscopy with surface tension measurements or conductometry for the understanding of the mechanism of these types of interactions (Ali et al, ; Ansari et al, ; Gokturk et al, ; Kabir‐ud‐Din et al, , ; Maswal et al, ; Rub et al, ). Previously, we reported a study on the binding characteristics of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in the presence of sodium dodecyl sulfate (SDS) and Triton X‐100 (TX‐100) micelles employing spectroscopy and surface tension measurements.…”

Investigation of pH-responsive block glycopolymers with different structures for the delivery of doxorubicin

“…The CMCs of self-assemblies depended on the hydrophobicity of core segment to a great extent owing to the assembling driving force of similarity-intermiscibility. 35 Herein, the PEG-b-P(DEA-co-GAMA) self-assembled micelles represented a quite high CMC compared with the other two triblock-assembled micelles due to the hydrophilic PGAMA segment mixed core, while the core of the other two micelles were pH-sensitive PDEA segment only. Due to the respectable characteristics of the PGAMA, it was extensively applied in drug delivery system to a Measurement is obtained by GPC and PEG as standard sample.…”