Interaction between CETP Polymorphism and Dietary Insulin Index and Load on Cardiovascular Risk Factors: A Cross-Sectional Study of Diabetic adults

Abstract

Background The objectives were to investigate the effect of the interaction between CETP Taq1B polymorphism, Dietary Insulin Index and Insulin Load (DII and DIL) on cardiovascular risk factors among diabetic patients. Methods In this cross-sectional study, blood samples were collected from 220 patients. DIL and DII were obtained via validated FFQ. CETP Taq1B polymorphism was genotyped by the PCR-RFLP method. Results The highest BMI (P = 0.08) and WC (P = 0.01) values were observed in B2B2 genotype with the highest adherence to DII. Patients with B1B1 genotype who were in the highest DIL tertile had lower LDL/HDL (P = 0.001), TG (P = 0.03), and higher HDL (P = 0.02). The highest SOD (P = 0.01), PGF2α (P = 0.04), CRP (P = 0.02), and IL-18 (P = 0.06) was observed in B2B2 genotype carriers with the highest DIL adherence. Individuals with B2B2 genotype in the highest tertile of DII had higher CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02). B1B1 homozygotes who were in the highest tertile of DII had lower lipid profile TG (P = 0.02), LDL (P = 0.08), and LDL/HDL < 0.001. Conclusion Based on the current study, it may be proposed that CETP Taq1B polymorphism can be associated with CVD risk factors in diabetic patients with high adherence to insulin indices, including DII and DIL