2021
DOI: 10.1242/bio.058982
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Interaction between Discs large and Pins/LGN/GPSM2: a comparison across species

Abstract: The orientation of the mitotic spindle determines the direction of cell division, and therefore contributes to tissue shape and cell fate. Interaction between the multifunctional scaffolding protein Discs large (Dlg) and the canonical spindle orienting factor GPSM2 (called Pins in Drosophila and LGN in vertebrates) has been established in bilaterian models, but its function remains unclear. We used a phylogenetic approach to test whether the interaction is obligate in animals, and in particular whether Pins/LG… Show more

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Cited by 7 publications
(18 citation statements)
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“…The spindle orienting function of Gpsm2 and its homologs is highly conserved throughout evolution, and may have evolved as early as the time when bilateria and cnidaria diverged (Schiller & Bergstralh, 2021; Wavreil & Yajima, 2020). While LGN and its orthologs have an evolutionarily-conserved role in oriented cell divisions, the manner and pattern in which LGN localizes to the cell cortex varies among epithelial tissues.…”
Section: Discussionmentioning
confidence: 99%
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“…The spindle orienting function of Gpsm2 and its homologs is highly conserved throughout evolution, and may have evolved as early as the time when bilateria and cnidaria diverged (Schiller & Bergstralh, 2021; Wavreil & Yajima, 2020). While LGN and its orthologs have an evolutionarily-conserved role in oriented cell divisions, the manner and pattern in which LGN localizes to the cell cortex varies among epithelial tissues.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to Insc and Gαi family proteins, a growing list of proteins— including Dlg, E-cadherin, Frmpd1/4 and afadin—have been found to promote the cortical localization of LGN in different contexts (Carminati et al, 2016; Gloerich, Bianchini, Siemers, Cohen, & Nelson, 2017; Schiller & Bergstralh, 2021; Wee, Johnston, Prehoda, & Doe, 2011; Yuzawa et al, 2011). Although autoinhibition and phosphorylation are mechanisms known to regulate LGN’s ability to interact with proteins that promote its membrane association (Bergstralh et al, 2017; Johnston, Hirono, Prehoda, & Doe, 2009; Pan et al, 2013), comparatively less is known about negative regulators.…”
Section: Discussionmentioning
confidence: 99%
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“…The finding that there are two distinct mechanisms for activating pulling raises the question of how and for what purpose they evolved. Phylogenetic analysis indicates that the interaction between Pins and Dlg is evolutionarily ancient; it is predicted to have evolved in Cnidaria, predating the appearance of Inscuteable orthologs (Schiller and Bergstralh, 2021). It is therefore tempting to speculate that Inscuteable-mediated spindle orientation evolved to promote cell type diversity, particularly in the more complex bilaterian nervous system.…”
Section: Dlg and Inscuteable Function As Distinct Activators For The ...mentioning
confidence: 99%