Interaction between green tea extract and 99mTc-pertechnetate on in vivo distribution

Sabuncu, Burak; Müftüler, Fazilet Zümrüt Biber; Kılçar, Ayfer Yurt; Cekic, Betul; Uçar, Eser; Ünak, Perıhan

doi:10.1007/s10967-014-3089-y

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…In addition to their dietary properties, many medicinal plants can be promising sources of natural products with beneficial activity in human and animal health [2]. In vitro and in vivo investigations have been performed to evaluate their biological activities, biodistribution and toxicity [3][4][5]. The antioxidant and antimicrobial activity of different extracts obtained from several edible or non-edible, medicinal plants, including their leaves, bark and roots [6,7], flower, fruits and seeds [8], resins and tars [9,10] and seedcakes have been comprehensively studied.…”

Section: Introductionmentioning

confidence: 99%

Phyto-Niosomes:In VitroAssessment of the Novel Nanovesicles Containing Marigold Extract

Ün

Barlas

Yavuz

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

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Herbal compounds so called phyto-constituents illustrate poor absorption by living cells.Phytosomes are advanced form of herbal compounds that show higher absorption rate and bioavailability which results better than conventional plant extracts. Niosomes which are made of non-ionic surfactants create better chemical and stability conditions besides lipid vesicles. This study covers the preparation, characterization and cell culture applications of phyto-niosomes of Marigold extract. Before the encapsulation process, extracts of selected plants were prepared and the extract that presents best bio-activity was chosen. The resulting phyto-niosomes were characterized and their biological activities including cytotoxicity, wound healing and antioxidant activity were investigated.

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Section: Introductionmentioning

confidence: 99%

Phyto-Niosomes:In VitroAssessment of the Novel Nanovesicles Containing Marigold Extract

Ün

Barlas

Yavuz

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

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A perspective on plant origin radiolabeled compounds, their biological affinities and interaction between plant extracts with radiopharmaceuticals

Müftüler

Kılçar

Ünak

2015

J Radioanal Nucl Chem

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The Effect of Bitter Melon (Momordica charantia) Extract on the Uptake of 99mTc Labeled Paclitaxel: In Vitro Monitoring in Breast Cancer Cells

Kılçar

Yıldız

Doğan

et al. 2020

ACAMC

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BACKGROUND: Bitter Melon Extract (BME) is widely used for the treatment of various diseases worldwide, due to its rich phytochemical and antioxidant content. The well-known anti-cancer drug, Paclitaxel (PAC) plays a major role in the treatment of various cancer types such as ovarian, breast, and lung cancer. Technetium-99m (99mTc) radiolabeled paclitaxel is emerging as an imaging probe for breast cancer in vivo. 99mTc labeled compounds have been attracting more scientific attention since the achievement of earlier researches in Nuclear Medicine. People consume several types of plant origin diet without knowing the interaction with radiolabeled compounds or radiopharmaceuticals. OBJECTIVE: In the current study, we aimed to monitor potential effects of the BME on the uptake of 99mTc labeled Paclitaxel (99mTcPAC) on MCF-7 (ER+) and MDA-MB-231 (ER-) cell lines by using in vitro methods. METHODS: BME was obtained by extraction of BM seeds by 80% ethanol. PAC was labeled with 99mTc by stannous chloride (SnCl2) as reducing agent. Cytotoxicity and incorporation assays were performed on MCF-7 and MDA-MB-231 cells within the cell culture studies. RESULTS: The uptake value of 99mTc-PAC on MCF-7 cells at 240 minutes was 6.20% and BME treated 99mTc-PAC values was 17.39%. CONCLUSION: It is observed that BME treatment has a significant effect on uptake of the 99mTc-PAC on MCF-7 cells which is a known estrogen receptor positive breast carcinoma cell line. It is concluded that this effect could be due to the estrogen receptor dependent interaction of BME.

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Interaction between green tea extract and 99mTc-pertechnetate on in vivo distribution

Cited by 3 publications

References 29 publications

Phyto-Niosomes:In VitroAssessment of the Novel Nanovesicles Containing Marigold Extract

Phyto-Niosomes:In VitroAssessment of the Novel Nanovesicles Containing Marigold Extract

A perspective on plant origin radiolabeled compounds, their biological affinities and interaction between plant extracts with radiopharmaceuticals

The Effect of Bitter Melon (Momordica charantia) Extract on the Uptake of 99mTc Labeled Paclitaxel: In Vitro Monitoring in Breast Cancer Cells

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