Interaction between inhibitory pathways to principal cells in the lateral geniculate nucleus of the cat

Ahlsén, Gunilla; Lindström, Sivert; Lo, Fu‐Sun

doi:10.1007/bf00238961

Cited by 108 publications

(94 citation statements)

References 38 publications

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“…Consistent with the reduction in dLGN spiking generated by electrical (Marrocco et al, 1982;Ahlsén et al, 1985) or transcranial magnetic stimulation of V1 (de Labra et al, 2007), as well as previous reports in the mouse visual system (Olsen et al, 2012), we found that synchronous activation of Ntsr1 cells elicits reduction in spike count, presumably through activation of RE or local inhibitory input to dLGN relay cells. However, Ntsr1 activity does not always result in net inhibition, as evidenced by our Arch experiments removing Ntsr1 activity.…”

Section: Putative Mechanismssupporting

confidence: 92%

Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus

Denman

Contreras

2015

Journal of Neuroscience

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Understanding the role of corticothalamic projections in shaping visual response properties in the thalamus has been a longstanding challenge in visual neuroscience. Here, we take advantage of the cell-type specificity of a transgenic mouse line, the GN220-Ntsr1 Cre line, to manipulate selectively the activity of a layer 6 (L6) corticogeniculate population while recording visual responses in the dorsal lateral geniculate nucleus (dLGN). Although driving Ntsr1 projection input resulted in reliable reduction in evoked spike count of dLGN neurons, removing these same projections resulted in both increases and decreases in visually evoked spike count. Both increases and decreases are contrast dependent and the sign is consistent over the full range of contrasts. Tuning properties suggest wide convergence of Ntsr1 cells with similar spatial and temporal frequency tuning onto single dLGN cells and we did not find evidence that Ntsr1 cells sharpen spatiotemporal filtering. These nonspecific changes occur independently of changes in burst frequency, indicating that Ntsr1 corticogeniculate activity can result in both net excitation and net inhibition.

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Section: Putative Mechanismssupporting

confidence: 92%

Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus

Denman

Contreras

2015

Journal of Neuroscience

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“…It has recently been suggested that the recurrent inhibitory system may function as a variable gain regulator for the transmission through the d.l.g.n. (Ahlsen et al 1983a). With the recurrent pathway operative the dynamic range of the visual signals passing through the nucleus will be reduced compared to the situation without recurrent inhibition.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, an external influence on the recurrent interneurones is a prerequisite for the suggested gain control of the transmission through the d.l.g.n. (Ahlsen et al 1983a). …”

Section: Introductionmentioning

confidence: 99%

Inhibition from the brain stem of inhibitory interneurones of the cat's dorsal lateral geniculate nucleus.

Ahlsén¹,

Lindström²,

Lo³

1984

The Journal of Physiology

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SUMMARY1. Brain-stem control of inhibitory circuits in the dorsal lateral geniculate nucleus (d.l.g.n.) of the cat was studied with extracellular recordings from functionally identified interneurones and with intracellular recordings from principal cells.2. Perigeniculate neurones, the recurrent inhibitory interneurones of the d.l.g.n., were inhibited by low-threshold stimulation within a wide bilateral field of the brainstem reticular formation extending from the rostral mesencephalon to the caudal medulla oblongata. The inhibition had a latency of 10-12 ms for stimulation sites in the mesencephalon and a duration of about 100 ms. The brain-stem stimulation evoked large hyperpolarizing potentials in intracellularly recorded perigeniculate neurones, indicating that the effect was due to post-synaptic inhibition.3. Intrageniculate interneurones, the feed-forward inhibitory interneurones of the d.l.g.n., were inhibited with a similar time course from the same region of the brain stem.4. Both feed-forward and recurrent inhibitory post-synaptic potentials (i.p.s.p.s) in principal cells were depressed by a preceding stimulation of brain-stem sites effective for the interneurones. The depression had about the same time course as the inhibition of the interneurones and it occurred without a concomitant change in the membrane potential of the recorded principal cells.5. A small depolarizing potential, with a latency of 10-20 ms, was observed in some principal cells after brain-stem stimulation. The potential reversed polarity when i.p.s.p.s were reversed by current injection into the recorded cell indicating that it was due to disinhibition of the principal cells.6. The possible neuronal pathway for the inhibition of the d.l.g.n. interneurones is considered and it is proposed that the effect is mediated by a group of neurones located in the caudal mesencephalon and the rostral pons close to the fibres of the brachium conjunctivum.

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“…The cortico-geniculate pathway forms one limb in a disynaptic recurrent excitatory system, earlier proposed to serve as a neuronal gain regulator used to enhance signal transmission through the l.g.n. during visual attention (Ahlsen, et al 1985). By the additional projection to layer 4 simple cells, the main cortical target of principal cells, the gain increasing capacity of the layer 6 system would be greatly improved without jeopardizing the stability of the circuits.…”

Section: Functional Considerationsmentioning

confidence: 99%

Synaptic excitation of neurones in area 17 of the cat by intracortical axon collaterals of cortico‐geniculate cells.

Ferster¹,

Lindström²

1985

The Journal of Physiology

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SUMMARY1. Antidromic activation of layer 6 cortico-geniculate cells from the lateral geniculate nucleus (l.g.n.) was used to study synaptic effects mediated by their intracortical axon collaterals. A specific stimulation procedure, earlier shown to suppress geniculo-cortical synaptic effects and to enhance synaptic effects from layer 6 cell collaterals was employed to differentiate between inputs from the two pathways. Single cells in different cortical layers were recorded both extra-and intracellularly with glass micro-electrodes.2. Antidromic activation of cortico-geniculate cells at 10-16 Hz induced massive, usually repetitive, spike discharges in almost all cells in layers 2-5. The shortest latency for this synaptic activation (3-4-7 5 ms) was found for simple cells in layer 4. Cells in layers 2, 3 and 5 responded with progressively longer latencies. Corticogeniculate cells in layer 6 were atypical in that hardly any responded with synaptic discharges to the stimulation.3. Intracellular recordings from layer 4 cells revealed, besides a monosynaptic excitatory post-synaptic potential

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Interaction between inhibitory pathways to principal cells in the lateral geniculate nucleus of the cat

Cited by 108 publications

References 38 publications

Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus

Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus

Inhibition from the brain stem of inhibitory interneurones of the cat's dorsal lateral geniculate nucleus.

Synaptic excitation of neurones in area 17 of the cat by intracortical axon collaterals of cortico‐geniculate cells.

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