Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

Shen, Yuanyuan; Wang, Tianfu; Chin, Chienting; Diao, Xianfen; Chen, SiPing

doi:10.1007/s11434-012-5546-8

Cited by 6 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the bubble oscillation can induce the vessel wall dilation and depression under the external pressure field. [33,35] Experiments showed that some biological objects have higher elastic modulus (such as lymphocytes), and can be seen as no deformation of wall. [36] However, other biological objects have much lower elastic moduli.…”

Section: Resultsmentioning

confidence: 99%

Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation

Qian

Sun

et al. 2015

Chinese Phys. B

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation

Qian

Sun

et al. 2015

Chinese Phys. B

View full text Add to dashboard Cite

show abstract

“…The shear and circumferential stress on the vessel wall was estimated using Eqs. ( 17)- (19), respectively, after solving the model. Table I lists the calculation parameters used.…”

Section: Simulation Results and Discussion A Fem Simulation And Valid...mentioning

confidence: 99%

“…16 Table II in the Appendix summarizes the results of recent papers investigating the stresses (shear and circumferential) induced by a single MB confined within a micro-vessel or near its wall. Many of these studies 8,10,[17][18][19][20] have found that the shear and circumferential stress on the wall increases as the pressure which drives the bubble's oscillation (i.e., the acoustic pressure) is increased. With respect to the acoustic frequency, several previous studies 10, 17,18,[21][22][23] have found that the stresses and vessel displacement are maximized at various specific frequencies related to the resonance of the bubbles, vessel elasticity, and gap between walls.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional numerical analysis of wall stress induced by asymmetric oscillation of microbubble trains inside micro-vessels

Pang

Bai

et al. 2023

Physics of Fluids

View full text Add to dashboard Cite

Understanding the stress patterns produced by microbubbles (MB) in blood vessels is important in enhancing the efficacy and safety of ultrasound-assisted therapy, diagnosis and drug delivery. In this study, the wall stress produced by a non-spherical oscillation of MBs within the lumen of micro-vessels was numerically analyzed using a three-dimensional finite element method. We systematically simulated configurations containing an odd number of bubbles from three to nine, equally spaced along the long axis of the vessel, insonated at an acoustic pressure of 200 kPa. We observed that 3 MBs were sufficient to simulate the stress state of an infinite number of bubbles. As the bubble spacing increased the interaction between them weakened to the point that they could be considered to act independently. In the relationship between stress and acoustic frequency there were differences between the single and 3 MB cases. The stress induced by 3MBs was greater than the single bubble case. When the bubbles were near the wall, the shear stress peak was largely independent of vessel radius, but the circumferential stress peak increased with the radius. This study offers further insight into our understanding of, the magnitude and distribution of stresses produced by multiple ultrasonically excited MBs inside capillaries.

show abstract

“…Thus, numerical simulation is important and allows for a large variation of parameters. Although FEM has been used to simulate vessel deformation and generated circumference stress, only low amplitude ultrasonic pulses were applied [17,19,20]. In this study, intraluminal bubble dynamics induced by clinical LSW was simulated using FEM.…”

Section: Discussionmentioning

confidence: 99%

“…A 2D axisymmetric finite element numerical model was used to study the interaction between the elastic microvessel wall and oscillating microbubble in an ultrasound field using the fluid-solid interaction method [17]. The von Mises stress distribution over the microvessel wall is heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Intraluminal bubble dynamics induced by lithotripsy shock wave

Song

Bai

Zhou

2016

J. Phys. D: Appl. Phys.

View full text Add to dashboard Cite

Extracorporeal shock wave lithotripsy (ESWL) has been the first option in the treatment of calculi in the upper urinary tract since its introduction. ESWLinduced renal injury is also found after treatment and is assumed to associate with intraluminal bubble dynamics. To further understand the interaction of bubble expansion and collapse with the vessel wall, the finite element method (FEM) was used to simulate intraluminal bubble dynamics and calculate the distribution of stress in the vessel wall and surrounding soft tissue during cavitation. The effects of peak pressure, vessel size, and stiffness of soft tissue were investigated. Significant dilation on the vessel wall occurs after contacting with rapid and large bubble expansion, and then vessel deformation propagates in the axial direction. During bubble collapse, large shear stress is found to be applied to the vessel wall at a clinical lithotripter setting (i.e. 40 MPa peak pressure), which may be the mechanism of ESWLinduced vessel rupture. The decrease of vessel size and viscosity of soft tissue would enhance vessel deformation and, consequently, increase the generated shear stress and normal stresses. Meanwhile, a significantly asymmetric bubble boundary is also found due to faster axial bubble expansion and shrinkage than in radial direction, and deformation of the vessel wall may result in the formation of microjets in the axial direction. Therefore, this numerical work would illustrate the mechanism of ESWL induced tissue injury in order to develop appropriate counteractive strategies for reduced adverse effects.

show abstract

Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

Cited by 6 publications

References 14 publications

Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation

Microflow-induced shear stress on biomaterial wall by ultrasound-induced encapsulated microbubble oscillation

Three-dimensional numerical analysis of wall stress induced by asymmetric oscillation of microbubble trains inside micro-vessels

Intraluminal bubble dynamics induced by lithotripsy shock wave

Contact Info

Product

Resources

About