Interaction between silicon dioxide and dipalmitoylphosphatidylcholine (DPPC) vesicles

Mohd, Hur Munawar Kabir; Ahmad, Ainee Fatimah; Radiman, Shahidan; Mohamed, Faizal K.P. Kunchi; Rosli, Nur Ratasha Alia Md; Ayob, Muhammad Taqiyuddin Mawardi; Rahman, Irman Abdul

doi:10.1063/1.4895172

Cited by 2 publications

(4 citation statements)

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“…A DPPC lipid molecule has two head groups, namely, phosphate and choline groups. DPPC lipids have been extensively studied using both experimental − and computational approaches. − DPPC lipids are suitable for making stable vesicles as they are in the gel state at physiological temperatures. ,− , Furthermore, mixtures of DPPC lipids and amphiphiles with bulky head groups (like the ones used in this study) also form stable vesicles in aqueous solution . Vesicles are created by varying the relative concentration and generation (G1 through G5) of the dendrons.…”

Section: Materials and Methodsmentioning

confidence: 99%

“…25−27 DPPC lipids are suitable for making stable vesicles as they are in the gel state at physiological temperatures. 5,[22][23][24]28 Furthermore, mixtures of DPPC lipids and amphiphiles with bulky head groups (like the ones used in this study) also form stable vesicles in aqueous solution. 29 Vesicles are created by varying the relative concentration and generation (G1 through G5) of the dendrons.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Self-Organization of Mobile, Polyelectrolytic Dendrons on Stable, Amphiphile-Based Spherical Surfaces

Banerjee

Dutt

2023

Langmuir

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Spherical surfaces bearing mobile, solvophilic chains are ubiquitous. These systems are found in nature in the form of biological cells bearing carbohydrate chains, or glycans, or in drug delivery systems such as vesicles bearing polyethylene glycol chains and carrying therapeutic molecules. The self-organization of the chains on the spherical surface dictates the stability and functionality of the latter and is determined by key factors such as the interchain, chain–surface interactions, excluded volume, concentration of the chains, and external environment. This study develops a fundamental understanding of how these factors control the organization of mobile, solvophilic chains while preserving the stability of the spherical surface. To that end, the study focuses on the organization of polyamidoamine dendrons on the surface of a dipalmitoylphosphatidylcholine-based vesicle. The excluded volume of the chains and the external environment are, respectively, controlled via the dendron generation and the pH. For acidic and basic pH environments, the dendrons are extended away from the surface. As a consequence, the vesicles are able to accommodate significantly higher concentration of dendrons on their surface without rupturing. For acidic pH, the dendrons change their conformation to avoid intermeshing. However for basic pH, the dendrons only change their conformation at extremely high concentrations due to excluded volume effects. These conformational changes are attributed to the number of protonated dendron residues that vary as a function of pH. The results from this study will advance diverse subdisciplines within cell biology, biomedicine, and pharmaceuticals.

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Section: Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Self-Organization of Mobile, Polyelectrolytic Dendrons on Stable, Amphiphile-Based Spherical Surfaces

Banerjee

Dutt

2023

Langmuir

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“…DPPC was selected due to its biocompatibility as it is lung surfactant. 21 DPPC has been extensively used in many computational 22–24 and experimental studies 25–28 and hence, its physico-chemical properties are well characterized. In addition, a DPPC membrane is in the gel state at physiological temperatures which makes it suitable for forming stable vesicles which encompass amphiphiles with bulky water soluble head groups.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, a DPPC membrane is in the gel state at physiological temperatures which makes it suitable for forming stable vesicles which encompass amphiphiles with bulky water soluble head groups. 25–30 The characteristics of the vesicles encompassing molecular species with different relative concentrations and generations of the dendrons (namely, generation 1 (G1) through generation 6 (G6)) are studied. The dynamics of the system is resolved over extensive spatiotemporal scales via the molecular dynamics (MD) simulation technique used in conjunction with the explicit solvent coarse-grained (CG) Martini force field.…”

Section: Methodsmentioning

confidence: 99%

Dendronized vesicles: formation, self-organization of dendron-grafted amphiphiles and stability

2021

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Interaction between silicon dioxide and dipalmitoylphosphatidylcholine (DPPC) vesicles

Cited by 2 publications

References 0 publications

Self-Organization of Mobile, Polyelectrolytic Dendrons on Stable, Amphiphile-Based Spherical Surfaces

Self-Organization of Mobile, Polyelectrolytic Dendrons on Stable, Amphiphile-Based Spherical Surfaces

Dendronized vesicles: formation, self-organization of dendron-grafted amphiphiles and stability

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