Interaction between the Components of the Interferon γ Receptor Complex

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

“…EMSAs were performed with a 22-base pair sequence containing a Stat1␣-binding site corresponding to the GAS (IFN-␥ activation sequence) element in the promoter region of the human IRF-1 gene (5Ј-GATCGATTTCCCCGAAATCATG-3Ј) as described (33,34).…”

Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

“…[33][34][35][36] Although to date only the crystal structure of the complex between IFN-␥ and its soluble IFN-␥ R1 receptor has been solved, 37 based on the structural homology of the ligands and the receptor complexes 29,30,37-39 a number of residues of IL-10 were proposed to be involved in interaction with the receptor. 30 The sequence of cytomegalovirus-encoded IL-10 (cmvIL-10) is included in the alignment because it provides additional information due to unique features of this protein.…”

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

“…means we predict that Stat3 and Jak1, respectively, recruited to the receptor chain based on the structure of the intracellular domain (Rashidbaigi et al, 1986;Jung et al, 1987Jung et al, , 1988Jung et al, , 1990. The second chains (the IFN-gR2 or IL-10R2 chains, or R2 chains; also designated Rb chains) are required to assemble an active intracellular receptor complex and thus to initiate the signal transduction events (Figures 3 and 4) (Kotenko et al, 1995(Kotenko et al, , 1996. The intracellular domains of both the IFN-g and IL-10 R1 chains are associated with Jak1, whereas the second chains bring to their respective complexes distinct Jak family members associated with the R2 intracellular domains.…”