Interaction between the genetic variant of rs696217‐ghrelin and food intake and obesity and dyslipidemia

Yadegari, Mehran; Zare‐Feyzabadi, Reza; Zakariaeiseraji, Mohanna; Sahebi, Reza; Shabani, Niloofar; Khedmatgozar, Hamed; Ghazizadeh, Hamideh; Mohammadi‐Bajgiran, Maryam; Jalalian, Melika; Zoghi, Mohadese; Darban, Reza Assaran; Mohammadian-Ghosooni, Mahdi; Esmaily, Habibollah; Avan, Amir

doi:10.1111/ahg.12443

Cited by 18 publications

(5 citation statements)

References 35 publications

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“…In a study of Becer and Ergoren (2021), it has been shown that the frequency of the minor allele rs696217 T (Met72) was significantly higher in obese individuals. At the same time, in the study of Yadegari et al (2022) individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among individuals. No significant relationship has been found between the two groups regarding the lipid profile and TT genotype.…”

Section: Tablementioning

confidence: 84%

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population

Prodan,

Dzubanovsky,

Kamyshnyi

et al. 2023

Endocrine Regulations

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Objective. Over the past four decades, the prevalence of obesity has tripled and limited genetic studies with specific SNPs have been conducted, but no investigations using ghrelin and obestatin prepropeptide (GHRL) gene have been reported in the Ukrainians population. The aim of this study was to evaluate changes in the level of metabolic hormones in the blood of obese patients in relation to the GHRL (rs696217) polymorphism. Methods. The study involved 53 obesity cases and 48 non-obesity subjects (controls). The GHRL (rs696217) polymorphism was genotyped using a TaqMan real-time polymerase chain reaction method. Blood hormones were determined with commercially available kits using a Multi-skan FC analyzer. Results. Carriers of the T allele of the GHRL (rs696217) polymorphism were statistically significantly more in patients diagnosed with obesity compared to controls indicating a genetically determined cause of obesity. We also established a significant effect of the presence of the T allele of the GHRL (rs696217) polymorphism on the decrease in the adiponectin level and the increase of resistin level in obese patients. The study of the effect of genotypes (TT, GT, GG) of the GHRL (rs696217) polymorphism on the metabolic hormone levels in the blood of obese patients did not show reliably significant differences. Conclusions. The presence of the T allele of the GHRL (rs696217) polymorphism in Ukrainian population indicates an increased risk of the obesity development regardless on the homozygous or heterozygous genotype.

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Section: Tablementioning

confidence: 84%

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population

Prodan,

Dzubanovsky,

Kamyshnyi

et al. 2023

Endocrine Regulations

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“…Previous studies have suggested some candidate genes for MetS, including the insulin-induced gene 2 (INSIG2) [6,7], ghrelin gene (GHRL) [8][9][10][11][12][13][14], leptin (LEP) [7,11,[15][16][17][18][19], and leptin receptor genes (LEPR) [11,16,17,19,20]. For instance, INSIG2 rs17047764 was shown to be associated with antipsychotic-related weight gain [6], whereas rs17587100, rs10490624, and rs17047764 localized within or near the INSIG2 gene had a strong association with clozapine-induced BMI gain in patients with schizophrenia [7].…”

Section: Introductionmentioning

confidence: 99%

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Boiko

Pozhidaev

Paderina

et al. 2022

Genes

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Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia.

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“…It is important to highlight the need to study and investigate the regulation of genes and their functional polymorphisms that regulate the interaction between energy balance and diet, since it is known that energy intake is a key factor in weight control 10 . Among these genes, it is possible to refer to those related to the melanocortin 4 receptor, fat mass and obesity‐associated genes; leptin, ghrelin, and their receptors; and cholecystokinin 11–17 …”

Section: Introductionmentioning

confidence: 99%

“…10 Among these genes, it is possible to refer to those related to the melanocortin 4 receptor, fat mass and obesity-associated genes; leptin, ghrelin, and their receptors; and cholecystokinin. [11][12][13][14][15][16][17] Still in relation to energy expenditure/storage, adipose tissue (AT), especially white AT (WAT), is the main organ that stores energy, whereas brown/beige AT (BAT) dissipates it by non-shivering thermogenesis via by uncoupling aerobic mitochondrial respiration by uncoupling protein 1 (UCP-1). 18,19 Conversion of WAT into BAT, or "browning" of WAT, is defined as the conversion from white, energy-storing adipocytes into beige and brown, energy-dissipating adipocytes.…”

Section: Introductionmentioning

confidence: 99%

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

et al. 2022

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Obesity is the result of the long-term energy imbalance between the excess calories consumed and the few calories expended. Reducing the intake of energy dense foods (fats, sugars), and strategies such as fasting and caloric restriction can promote body weight loss. Not only energy in terms of calories, but also the specific composition of the diet can affect the way the food is absorbed and how its energy is stored, used or dissipated. Recent research has shown that bioactive components of food, such as polyphenols and vitamins, can influence obesity and its pathologic complications such as insulin resistance, inflammation and

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Interaction between the genetic variant of rs696217‐ghrelin and food intake and obesity and dyslipidemia

Cited by 18 publications

References 35 publications

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

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