Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma

Ma, Xiuru; Li, Xiaoming; Lu, Xiao‐Jie; Jia, Lifeng; Li, Hui; Song, Qing

doi:10.1007/s13277-015-3684-8

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…They observed expression of these receptors in all specimens of HPSCC. However, when performed a ratio analysis of these two receptors expression, it was observed that TNFR2 expression is negatively correlated to TNFR1 expression, suggesting that the TNFR1 can dominate the interactions between the two receptors and, therefore, the clinical HPSCC outcome [44].…”

Section: Discussionmentioning

confidence: 99%

TNFR1single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulatein situcervical TNFR1 expression

et al. 2019

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TNF-α is involved in HPV infection control by triggering cell signaling through binding in specific receptors TNFR1 and TNFR2. Genetic polymorphisms in these receptors may influence TNF-α signaling. Herein, we investigated TNFR1 rs767455 and rs2234649 single nucleotide polymorphisms, and TNFR1 protein expression in cervical squamous intraepithelial lesions (SIL) to identify their role in cervical pre-malignant development. SIL patients ( n = 179) and healthy volunteers ( n = 227) were enrolled for TNFR1 genotyping analysis by PCR-RFLP in blood samples and TNFR1 protein expression in cervical tissue by immunohistochemistry. No statistical differences regard genotypes and allelic frequencies for both polymorphisms were observed. Cervical TNFR1-expressing cells were rare in epithelium and basal layer regardless the groups. However, a progressive increase in infiltrating cells was observed in the stromal area, mainly in high SIL (HSIL) group compared to low SIL (LSIL, p < 0.001) and control ( p < 0.001) groups. TNFR1-expressing cells frequency was higher in TNFR1 rs767455AG/GG ( p < 0.001), and in rs2234649AA ( p < 0.001) genotypes carries in HSIL subgroup. These data indicated that TNFR1-expression is abrogated in cervical epithelium, where HPV-induced pre-malignant lesion occurs, increasing its frequency in inflammatory cells in stroma, and is genetically controlled by TNFR1 rs767455AG /GG and rs234649AA genotypes. These biomarkers may be useful to identify cervical precancerous lesions progression.

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Section: Discussionmentioning

confidence: 99%

TNFR1single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulatein situcervical TNFR1 expression

et al. 2019

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“…Tumor necrosis factor receptor 1 (TNFR1) is a membranous receptor that anchors on the surface of the cell membrane, which belongs to the TNF receptor superfamily ( 6 , 7 ). The upregulation of TNFR1 has been shown to be associated with clinical staging, T stage, cervical lymph node metastasis and histological grade in HPSCC ( 8 ). The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) plays an important role in the endoplasmic reticulum stress and is known to be highly expressed in various human neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Aberrantly expressed genes and miRNAs in human hypopharyngeal squamous cell carcinoma based on RNA‑sequencing analysis

Wang²,

Fei

et al. 2018

Oncol Rep

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Abstract. The aim of the present study was to investigate the key genes, miRNAs and pathways in hypopharyngeal squamous cell carcinoma (HPSCC) and to elucidate the mechanisms underlying HPSCC development. The gene and microRNA (miRNA) expression profiles of HPSCC tissues and adjacent normal tissues from three subjects were obtained. Differentially expressed genes (DEGs) and differentially expressed miRNAs were identified in HPSCC. Functional annotation and protein-protein interaction (PPI) network were conducted to elucidate the biological functions of DEGs. A total of 160 DEGs (16 upregulated and 144 downregulated genes) and 79 differentially expressed miRNAs (48 upregulated and 31 downregulated miRNAs) were identified in HPSCC. The deregulated genes were significantly involved in spliceosome, cell cycle and RNA degradation. In the PPI network, S-phase kinase associated protein 1 (SKP1), non-POU domain containing octamer binding (NONO) and zinc activated ion channel (ZACN) were identified as hub proteins. On the whole, the present study may help to gain a comprehensive understanding of tumorigenesis in HPSCC and provide valuable information for early diagnosis and drug design of HPSCC in future research.

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Pre-clinical study of a TNFR1-targeted 18F probe for PET imaging of breast cancer

Zhang

et al. 2017

Amino Acids

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Tumor necrosis factor receptor 1 (TNFR1) is overexpressed in several varieties of carcinoma, including breast cancer. WH701 (Ala-Thr-Ala-Gln-Ser-Ala-Tyr-Gly), which was identified by phage display, can specifically bind to TNFR1. In this study, we labeled WH701 with F and investigated its tumor diagnostic value. WH701 was synthesized by standard Fmoc-solid phase synthetic protocols and conjugated by NOTA-NHS. NOTA-WH701 was radiolabeled withF using NOTA-AlF chelation reaction. The tumor target properties were evaluated in vitro and in vivo using MCF-7 xenografts and inflammation models. [F]AlF-NOTA-WH701 was labeled in 25 min with a decay-corrected yield of 38.1 ± 4.8% (n = 5) and a specific activity of 10.4-13.0 GBq/μmol. WH701 had relatively high affinity for MCF-7 cells in vitro and [F]AlF-NOTA-WH701 displayed relatively high tumor uptake in vivo. The tumor to muscle ratio was 4.25 ± 0.56 at 30 min post-injection (p.i.); further, there was a significant difference between the tumor/muscle and inflammation/muscle (3.22 ± 0.56) ratio, which could differentiate the tumor and inflammation. The tumor uptake of [F]AlF-NOTA-WH701 could be inhibited by 71.1% by unlabeled WH701 at 30 min p.i. We have developed a promising PET tracer [F]AlF-NOTA-WH701 for the noninvasive detection of breast cancer in vivo.

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Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma

Cited by 3 publications

References 26 publications

TNFR1single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulatein situcervical TNFR1 expression

TNFR1single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulatein situcervical TNFR1 expression

Aberrantly expressed genes and miRNAs in human hypopharyngeal squamous cell carcinoma based on RNA‑sequencing analysis

Pre-clinical study of a TNFR1-targeted 18F probe for PET imaging of breast cancer

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