Interaction effect between the BDNF Val66Met polymorphism and parental rearing for interpersonal sensitivity in healthy subjects

Suzuki, Akihito; Matsumoto, Yoshihiko; Shibuya, Naoshi; Sadahiro, Ryoichi; Kamata, Mitsuhiro; Enokido, Masanori; Goto, Kaoru; Otani, Koichi

doi:10.1016/j.psychres.2012.03.014

Cited by 18 publications

(19 citation statements)

References 30 publications

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“… 20 Likewise, Suzuki et al also investigated the relationship between PBI scores and IPSM scores in general adults and reported that low paternal care, paternal overprotection, and maternal overprotection increased interpersonal sensitivity. 34 On the other hand, Boyce et al 35 and Luty et al 19 reported negative results about the relationship between the quality of parenting and interpersonal sensitivity assessed by the IPSM in pregnant women and depressed patients, respectively. Because IPSM total scores were significantly correlated only with neglect, and not with punishment or sexual abuse as shown in this study, and neglect is moderately correlated with low parenting care (our unpublished data), low parenting care can be considered quite similar to neglect.…”

Section: Discussionmentioning

confidence: 99%

Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population

Otsuka¹,

Takaesu²,

Sato³

et al. 2017

NDT

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BackgroundRecent studies have suggested that multiple factors interact with the onset and prognosis of major depressive disorders. In this study, we investigated how child abuse, affective temperaments, and interpersonal sensitivity are interrelated, and how they affect depressive symptoms in the general adult population.Subjects and methodsA total of 415 volunteers from the general adult population completed the Patient Health Questionnaire-9, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire version, the Child Abuse and Trauma Scale, and the Interpersonal Sensitivity Measure, which are all self-administered questionnaires. Data were subjected to structural equation modeling (Mplus), and single and multiple regression analyses.ResultsThe effect of child abuse on depressive symptoms was mediated by interpersonal sensitivity and 4 affective temperaments, including depressive, cyclothymic, anxious, and irritable temperaments. In addition, the effect of these temperaments on depressive symptoms was mediated by interpersonal sensitivity, indicating the indirect enhancement of depressive symptoms. In contrast to these 4 temperaments, the hyperthymic temperament did not mediate the effect of child abuse on depressive symptoms; its effect was not mediated by interpersonal sensitivity. However, a greater hyperthymic temperament predicted decreased depressive symptoms and interpersonal sensitivity, independent of any mediation effect.LimitationsBecause this is a cross-sectional study, long-term prospective studies are necessary to confirm its findings. Therefore, recall bias should be considered when interpreting the results. As the subjects were adults from the general population, the results may not be generalizable towards all patients with major depression.ConclusionThis study suggests that child abuse and affective temperaments affect depressive symptoms partly through interpersonal sensitivity. Interpersonal sensitivity may have a major role in forming the link between abuse, affective temperament, and depression.

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Section: Discussionmentioning

confidence: 99%

Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population

Otsuka¹,

Takaesu²,

Sato³

et al. 2017

NDT

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“…We extended previous findings in this sample by exploring whether the BDNF genotype moderated the effects of parenting in predicting the ERN, and found that parenting only impacted error-processing among children with a met allele. Previous work suggests that carriers of the BDNF met allele are more affected by parenting behavior (Ibarra et al, 2014; Park et al, 2014; Suzuki et al, 2012; Willoughby et al, 2013), display deficits in extinction learning (Johnson & Casey, 2014; Peters et al, 2010; Soliman et al, 2010), and are more susceptible to psychopathology (Neves-Pereira et al, 2002; Sen et al, 2003; Sklar et al, 2002). Harsh parenting may operate in a similar way as fear-learning paradigms in the lab, wherein children associate making mistakes with punishment (i.e., parental criticism).…”

Section: Discussionmentioning

confidence: 99%

“…If we conceptualize harsh parenting as a form of fear-learning wherein children learn to associate making mistakes with punishment, we might expect children with the met allele to be less able to extinguish this association, despite experiencing other situations wherein their mistakes are not punished. Furthermore, previous studies have found that parenting behaviors have a greater impact on children’s psychological outcomes among youth carrying a met allele (Ibarra et al, 2014; Park et al, 2014; Suzuki et al, 2012; Willoughby, Mills-Koonce, Propper, & Waschbusch, 2013). Given these findings, we hypothesized that young children with the BDNF met allele may be differentially impacted by harsh parenting (i.e., a more punishing learning environment) compared to children without the met allele.…”

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confidence: 99%

A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children

Meyer¹,

Hajcak²,

Hayden³

et al. 2017

Dev Psychopathol

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The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed. We found that harsh parenting predicted an increased ERN only among children with a methionine allele of the BDNF genotype, and evidence of moderated mediation: the ERN mediated the relationship between parenting and internalizing diagnoses and dimensional symptoms only if children had a methionine allele. We tested this model with externalizing disorders, and found that harsh parenting predicted externalizing outcomes, but the ERN did not mediate this association. These findings suggest that harsh parenting predicts both externalizing and internalizing outcomes in children; however, this occurs through different pathways that uniquely implicate error-related brain activity in the development of internalizing disorders.

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“…There are many molecular neurobiological studies that address the important issues of attachment and parenting (Suzuki et al 2012). In this article, we will briefly review some of the pertinent data, with a primary focus on the neurogenetic factors.…”

Section: Neurogenetics Of Parental Rearing and Attachmentmentioning

confidence: 99%

Neurogenetic and Epigenetic Correlates of Adolescent Predisposition to and Risk for Addictive Behaviors as a Function of Prefrontal Cortex Dysregulation

Blum

Febo

Smith

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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As addiction professionals, we are becoming increasingly concerned about preteenagers and young adults' involvement with substance abuse as a way of relieving stress and anger. The turbulent underdeveloped central nervous system, especially in the prefrontal cortex (PFC), provides impetus to not only continue important neuroimaging studies in both human and animal models, but also to encourage preventive measures and cautions embraced by governmental and social media outlets. It is well known that before people reach their 20s, PFC development is undergoing significant changes and, as such, hijacks appropriate decision making in this population. We are further proposing that early genetic testing for addiction risk alleles will offer important information that could potentially be utilized by their parents and caregivers prior to use of psychoactive drugs by these youth. Understandably, family history, parenting styles, and attachment may be modified by various reward genes, including the known bonding substances oxytocin/vasopressin, which effect dopaminergic function. Well-characterized neuroimaging studies continue to reflect region-specific differential responses to drugs and food (including other nonsubstance-addictive behaviors) via either ''surfeit'' or ''deficit.'' With this in mind, we hereby propose a ''reward deficiency solution system'' that combines early genetic risk diagnosis, medical monitoring, and nutrigenomic dopamine agonist modalities to combat this significant global dilemma that is preventing our youth from leading normal productive lives, which will in turn make them happier.

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Interaction effect between the BDNF Val66Met polymorphism and parental rearing for interpersonal sensitivity in healthy subjects

Cited by 18 publications

References 30 publications

Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population

Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population

A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children

Neurogenetic and Epigenetic Correlates of Adolescent Predisposition to and Risk for Addictive Behaviors as a Function of Prefrontal Cortex Dysregulation

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