Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (<i>5‐</i><scp><i>HTTLPR</i>)</scp> genotype and family conflict on adolescent alcohol use and misuse

Kim, Jueun; Park, Aesoon; Glatt, Stephen J.; Eckert, Tanya L.; Vanable, Peter A.; Scott-Sheldon, Lori A. J.; Carey, Kate B.; Ewart, Craig K.; Carey, Michael P.

doi:10.1111/add.12753

Cited by 9 publications

(9 citation statements)

References 62 publications

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“…In a study done by Nilsson et al (2005), 5-HTT genotype and family relations interacted with one another and marginally predicted alcohol consumption in a group of 200 adolescents (p=0.05). Similar results were observed in a study by Kim et al (2015) among 5091 adolescents where a significant gene × environment interaction influenced alcohol misuse in these participants. This study showed that low-activity alleles of 5-HTTLPR polymorphisms (S and LG alleles), when compounded with family conflicts, resulted in significant increase in alcohol misuse.…”

Section: Discussionsupporting

confidence: 89%

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

et al. 2015

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Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.

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Section: Discussionsupporting

confidence: 89%

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

et al. 2015

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“…Data for this study were collected as part of the first assessment in a prospective, community-based study of 250 adolescents (29,30). Adolescents were recruited from both school and community venues.…”

Section: Methodsmentioning

confidence: 99%

Gender Differences in Relations among Perceived Family Characteristics and Risky Health Behaviors in Urban Adolescents

et al. 2016

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Background Research regarding the role of gender in relations between family characteristics and health risk behaviors has been limited. Purpose To investigate gender differences in associations between family processes and risk-taking in adolescents. Methods Adolescents (N = 249; mean age = 14.5 years) starting their first year at an urban high school in the northeastern U.S. completed self-report measures that assessed family characteristics (i.e., parental monitoring, family social support, family conflict) and health behaviors (i.e., tobacco use, alcohol use, marijuana use, sex initiation) as part of a prospective, community-based study. Multivariate logistic regression models were used to investigate gender differences in associations between the family characteristics and health behaviors. Results Among males, higher levels of perceived parental monitoring were associated with lower odds of using tobacco and having ever engaged in sex. Among females, higher levels of perceived parental monitoring were associated with lower odds of marijuana use, alcohol use, and having ever engaged in sex. However, in contrast to males, among females (a) higher levels of perceived family social support were associated with lower odds of alcohol use and having ever engaged in sex and (b) higher levels of perceived family conflict were associated with higher odds of marijuana use and having ever engaged in sex. Conclusion Family processes were more strongly related to health behaviors among adolescent females than adolescent males. Interventions that increase parental monitoring and family social support as well as decrease family conflict may help to protect against adolescent risk-taking, especially for females.

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“…45 In middle adolescence (mixed races), when they reported high levels of family conflict at 12, youth carrying low activity allele showed higher risk of drinking at age 15 than non-carriers. 25 Similarly, in middle and late adolescence (Swedish; race was not reported), when they reported poor family relations, youth carrying one long and one short allele were more likely to drink and get intoxicated cross-sectionally at ages 12 and 15 in two independent samples. 46 A study of Caucasian young adults also reported that, when exposed to higher levels of negative life events, college students carrying at least one short allele were more likely to engage in binge drinking (defined as 4 or more drinks for women and 5 or more drinks for men on one setting: 4þ/5þ) than non-carriers.…”

Section: -Hydroxy Tryptamine Transporter Linked Promoter Region (5-hmentioning

confidence: 98%

“…Twenty four out of the 42 identified studies were conducted in the United States, and the remaining studies were conducted in Germany (n ¼ 7), the Netherlands (n ¼ 5), Sweden (n ¼ 3), Australia (n ¼ 2), Estonia (n ¼ 1), and the United Kingdom (n ¼ 1). Among them, one study 25 used one sample collected in the United States and another in the United Kingdom.…”

Section: Sample Characteristicsmentioning

confidence: 99%

A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults

Kim

Park

2018

American J Addict

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This review suggests that GxE findings may advance our knowledge regarding which developmentally specific conditions result in the expression of candidate genes that influence youth alcohol use and misuse. However, since a significant number of studies had small sample sizes and most studies had small effect sizes, findings need replication across independent studies with large samples. (Am J Addict 2018;XX:1-19).

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Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse

Abstract: Compared with non-carriers, adolescents carrying the 5-HTTLPR low-activity allele are more susceptible to the effects of family conflict on alcohol misuse.

Cited by 9 publications

References 62 publications

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

Gender Differences in Relations among Perceived Family Characteristics and Risky Health Behaviors in Urban Adolescents

A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults

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