Interaction force measurements using atomic force microscopy for characterization and control of adhesion, dispersion and lubrication in particulate systems

Esayanur, Madhavan S; Yeruva, Suresh B.; Rabinovich, Ya. I.; Moudgil, Brij M.

doi:10.1163/1568561054890516

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…They concluded that controlling the deformation reduces and even eliminates the effects of nanoroughness on the probe-substrate contact area, promoting conditions described by the contact mechanics models (to be discussed in next section) for the spheresmooth substrate system. AFM finds another application in the exploration of the range of interaction forces [52] which can be utilized to predict, optimize, and design a variety of industrially relevant processes such as chemical mechanical polishing (CMP), powder flow and handling, and nanodispersions. Towards the resolution of the problem of Figure 11: Surface characteristics of worn surfaces of the steel grades investigated when exposed to the pin-on-disc test as observed in the SEM [17].…”

Section: 32mentioning

confidence: 99%

A Review on the Study of the Generation of (Nano)particles Aerosols during the Mechanical Solicitation of Materials

Shandilya

Bihan

Morgeneyer

2014

Journal of Nanomaterials

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This paper focuses on presenting the forefront of the interdisciplinary studies conceived towards the generation of the wear particles aerosol when materials are subjected to mechanical stresses. Various wear mechanisms and instrumentation involved during stress application and aerosolization of wear particles, as well as particles characterization, measurement, and modeling techniques are presented through the investigation of a series of contextual works which are emphasized on the identification of these aspects. The review is motivated from the fact that understanding mechanisms involved in wear-induced particle generation, both at nano- and at microscale, is important for many applications that involve surfaces sliding over each other due to various potential health aspects. An attempt has been made to explain how the information based on this broad spectrum of subjects discovered in this contribution can be used and improved in order to produce a more resilient, rational, and versatile knowledge base which has been found lacking in the present literature during its survey. The area of study is highly multidisciplinary since it involves aerosol, particle, and material sciences.

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Section: 32mentioning

confidence: 99%

A Review on the Study of the Generation of (Nano)particles Aerosols during the Mechanical Solicitation of Materials

Shandilya

Bihan

Morgeneyer

2014

Journal of Nanomaterials

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“…Several studies have dealt with the effect of micrometer/submicrometer-scale roughness on adhesion force, − particularly after the colloidal-probe atomic force microscopy (AFM) technique was introduced by Ducker et al Most of these studies reveal that roughness decreases the adhesion force, due to the reduction in real contact area between the probe and the substrate.…”

Section: Introductionmentioning

confidence: 99%

Controlling Adhesion Force by Means of Nanoscale Surface Roughness

et al. 2011

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Control of adhesion is a crucial aspect in the design of microelectromechanical and nanoelectromechanical devices. To understand the dependence of adhesion on nanometer-scale surface roughness, a roughness gradient has been employed. Monomodal roughness gradients were fabricated by means of silica nanoparticles (diameter ∼12 nm) to produce substrates with varying nanoparticle density. Pull-off force measurements on the gradients were performed using (polyethylene) colloidal-probe microscopy under perfluorodecalin, in order to restrict interactions to van der Waals forces. The influence of normal load on pull-off forces was studied and the measured forces compared with existing Hamaker-approximation-based models. We observe that adhesion force reaches a minimum value at an optimum particle density on the gradient sample, where the mean particle spacing becomes comparable with the diameter of the contact area with the polyethylene sphere. We also observe that the effect on adhesion of increasing the normal load depends on the roughness of the surface.

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“…The intrinsic roughness and irregular morphology of processed excipient and APIs in OIDP formulations, has severely limited the general use of colloid probe microscopy [93]. Most studies produced high variability in colloid probe adhesion measurements between formulation components, because it led to significant variation in the contact area between the colloidal probe and substrate, to which adhesion is directly proportional [94].…”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

Advanced microscopy techniques to assess solid-state properties of inhalation medicines

Shur

Price

2012

Advanced Drug Delivery Reviews

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Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. Control and reduction of risk require the introduction of a material science based approach to product development and the use of advanced analytical tools in understanding how the solid-state properties of the input materials influence structure and product functionality. The key issues to be addressed, at a microscopic scale, are understanding how the critical quality attributes of input materials influence surface, interfacial and particulate interactions within OIDPs. This review offers an in-depth discussion on the use of advanced microscopy techniques in characterising of the solid-state properties of particulate materials for OIDPs. The review covers the fundamental principles of the techniques, instrumentation types, data interpretation and specific applications in relation to the product development of OIDPs.

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Interaction force measurements using atomic force microscopy for characterization and control of adhesion, dispersion and lubrication in particulate systems

Cited by 10 publications

References 27 publications

A Review on the Study of the Generation of (Nano)particles Aerosols during the Mechanical Solicitation of Materials

A Review on the Study of the Generation of (Nano)particles Aerosols during the Mechanical Solicitation of Materials

Controlling Adhesion Force by Means of Nanoscale Surface Roughness

Advanced microscopy techniques to assess solid-state properties of inhalation medicines

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