“…From our studies and those of others, it is clear, however, that this targeting is achieved through interaction of the presynaptic Ca 2+ channel with a growing number of proteins known to be involved in synaptic vesicle exocytosis and endocytosis pathways (Catterall and Few, 2008;Chan et al, 2007;el Far et al, 1995;Evans and Zamponi, 2006;Khanna et al, 2007c;Khanna et al, 2007a;Khanna et al, 2007b;Kisilevsky and Zamponi, 2008;Stanley, 1997;Szabo et al, 2006). For example, syntaxin 1, the cardinal Cav2.2 partner protein (Sheng et al, 1994), is important for the incorporation of Ca 2+ channels into the release site apparatus.…”