1995
DOI: 10.1016/0014-5793(95)00156-4
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Interaction of a synaptobrevin (VAMP)‐syntaxin complex with presynaptic calcium channels

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Cited by 63 publications
(42 citation statements)
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“…From our studies and those of others, it is clear, however, that this targeting is achieved through interaction of the presynaptic Ca 2+ channel with a growing number of proteins known to be involved in synaptic vesicle exocytosis and endocytosis pathways (Catterall and Few, 2008;Chan et al, 2007;el Far et al, 1995;Evans and Zamponi, 2006;Khanna et al, 2007c;Khanna et al, 2007a;Khanna et al, 2007b;Kisilevsky and Zamponi, 2008;Stanley, 1997;Szabo et al, 2006). For example, syntaxin 1, the cardinal Cav2.2 partner protein (Sheng et al, 1994), is important for the incorporation of Ca 2+ channels into the release site apparatus.…”
Section: Discussionmentioning
confidence: 74%
“…From our studies and those of others, it is clear, however, that this targeting is achieved through interaction of the presynaptic Ca 2+ channel with a growing number of proteins known to be involved in synaptic vesicle exocytosis and endocytosis pathways (Catterall and Few, 2008;Chan et al, 2007;el Far et al, 1995;Evans and Zamponi, 2006;Khanna et al, 2007c;Khanna et al, 2007a;Khanna et al, 2007b;Kisilevsky and Zamponi, 2008;Stanley, 1997;Szabo et al, 2006). For example, syntaxin 1, the cardinal Cav2.2 partner protein (Sheng et al, 1994), is important for the incorporation of Ca 2+ channels into the release site apparatus.…”
Section: Discussionmentioning
confidence: 74%
“…Approximately 50% of [ 125 I]GVIA channels extracted from brain P2 or neurohypophysial nerve terminals was trapped by anti-syntaxin 1 antibodies but not by anti-csp antibodies. Coimmunoprecipitation has revealed the association of presynaptic calcium channels with a protein complex containing syntaxin, SNAP 25, VAMP, and synaptotagmin that is thought to play a role in locating docked vesicles within a microdomain of calcium entry (Yoshida et al, 1992;El Far et al, 1995;MartinMoutot et al, 1996). Our present findings do not support the view that csp is stably associated with this complex.…”
Section: Discussionmentioning
confidence: 99%
“…A mouse mAb to phosphorylated neurofilaments (SMI31) was obtained from Sternberger Monoclonal (Lutherville, MD), a mouse mAb to microtubule-associated protein 2 (MAP2) was obtained from NeoMarkers (Fremont, CA), and a mouse mAb to postsynaptic density protein-95 (PSD-95) was obtained from Upstate Biotechnology (Lake Placid, NY). Rabbit polyclonal antibodies to vesicle-associated membrane protein-2 (VAMP-2) were generated as described previously (El Far et al, 1995). A mouse mAb to synaptophysin (171B5) was kindly provided by S. C. Fujita (Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan).…”
Section: Methodsmentioning
confidence: 99%