Interaction of ACTN3 gene polymorphism and muscle imbalance effects on kinematic efficiency in combat sports athletes

Jung, Hansang; Lee, Nam‐Ju; Park, Sok

doi:10.20463/jenb.2016.06.20.2.1

Cited by 6 publications

(4 citation statements)

References 17 publications

(20 reference statements)

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“…In this regard, R allele carriers had increased passive hamstring stiffness compared to non-carriers, although this mechanical property did not increase the risk of strain injury (Miyamoto et al 2018). In athletes of combat sports (judo, taekwondo, boxing), subjects with the XX genotype had a similar kinematic efficacy in the lower limbs than R allele carriers, as assessed with knee, angle and pelvis moments during a sprint with a change of direction and a vertical jump (Jung et al 2016). Thus, the evidences that relate deficiency of α-actinin-3 with a higher risk for muscle injury during exercise are still inconsistent (Table 2).…”

Section: α-Actinin-3 Deficiency and Muscle Injurymentioning

confidence: 98%

More than a ‘speed gene’: ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries

et al. 2018

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A common null polymorphism (rs1815739; R577X) in the gene that codes for α-actinin-3 (ACTN3) has been related to different aspects of exercise performance. Individuals who are homozygous for the X allele are unable to express the α-actinin-3 protein in the muscle as opposed to those with the RX or RR genotype. α-actinin-3 deficiency in the muscle does not result in any disease. However, the different ACTN3 genotypes can modify the functioning of skeletal muscle during exercise through structural, metabolic or signalling changes, as shown in both humans and in the mouse model. Specifically, the ACTN3 RR genotype might favour the ability to generate powerful and forceful muscle contractions. Leading to an overall advantage of the RR genotype for enhanced performance in some speed and power-oriented sports. In addition, RR genotype might also favour the ability to withstand exercise-induced muscle damage, while the beneficial influence of the XX genotype on aerobic exercise performance

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Section: α-Actinin-3 Deficiency and Muscle Injurymentioning

confidence: 98%

More than a ‘speed gene’: ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries

et al. 2018

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“…The way in which an organism adapts to physical exertion depends, among others, on the regulation of many genes' expression e.g. IGF1, ACTN3, PPAR delta, ACE (Karlowatz et al, 2011;Jung et al, 2016;Maciejewska-Karłowska, 2013;Orysiak et al, 2015;Holdys et al, 2011). Their polymorphism turned out to be an important factor that influences the level of physical performance (Scheinowitz et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The relationship between CA repeat polymorphism of the <i>IGF-1</i> gene and the structure of motor skills in young athletes

Karpowicz

Krych²,

Karpowicz

et al. 2018

Acta Biochim Pol

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The map of candidate genes that can potentially affect physical fitness becomes larger every year, and they are associated with such aspects as respiratory and cardiovascular stability; body build and composition - especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exercise intolerance.The aim of this study was to analyze the relationship between the CA repeat polymorphism of the P1 promoter of the IGF1 gene and the structure of motor skills in the two groups of Polish young athletes in 2007-2009. In this study, 350 young sportsmen representing different sports disciplines were examined (age = 15.5 ± 0.5 years), by genotyping the IGF1 gene and determining the structure of motor skills using the International Physical Fitness Test (IPFT) battery. The multiple stepwise regression was used to determine the impact of the investigated motor skills on the indicator of the overall physical fitness, measured by the total score of the International Physical Fitness Test (IPFT). The analysis showed some regularity related to the character of the IGF1 gene polymorphism. It can be concluded that the two groups of young boys athletes practicing various sports disciplines (kinds of physical exercise) displayed similar associations between CA repeat polymorphism of the P1 promoter of the IGF1 gene and the level of motor effects. Our results suggest that this polymorphism may be a genetic marker of the physical performance phenotype. We demonstrated that CA repeat polymorphism of the P1 promoter of the IGF1 gene was associated with strength predispositions in the homozygous and non-carriers groups. In the group who were heterozygous it was speed-strength aptitudes.

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“…Side-to-side muscle imbalance has been well studied among athletes 4 9 12 22 23 26 27 34 43 . Findings indicate that strength imbalances increase the risk for acute 12 34 43 and chronic injury 4 23 26 , and that rehabilitation with resistance training can resolve these imbalances and decrease risk for injury 9 33 .…”

Section: Introductionmentioning

confidence: 99%

Upper Extremity Strength Imbalance after Mastectomy and the Effect of Resistance Training

Benton

Schlairet

2017

Sports Med Int Open

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The purpose of this non-randomized pre/post comparison trial was to explore the effect of resistance training (RT) on upper extremity strength imbalance in breast cancer survivors. Seventeen right-side dominant female breast cancer survivors (age: 58.2±2.7 years; BMI: 27.8±1.1 kg/m 2 ) with right-sided (RSM) or left-sided (LSM) mastectomy completed strength testing (30-second arm curl) before and after an 8-week RT program. At baseline, LSM (n=8) had equal strength bilaterally (right=16.8±1.1 repetitions; left=16.4±1.4 repetitions), whereas RSM (n=9) had impaired strength on the right (16.7±1.3 repetitions) compared to the left (18.6±1.1 repetitions) side ( p <0.01). After RT, RSM increased strength by 25% on the right (initially weaker) side and 19% on the left (initially stronger) side, which resolved the imbalance. By comparison LSM increased 19% on both sides that were initially equal in strength. Based on our findings, breast cancer survivors with dominant-side mastectomy are at risk for upper extremity strength imbalance that can be resolved with a relatively short-term RT program.

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Interaction of ACTN3 gene polymorphism and muscle imbalance effects on kinematic efficiency in combat sports athletes

Cited by 6 publications

References 17 publications

More than a ‘speed gene’: ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries

More than a ‘speed gene’: ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries

The relationship between CA repeat polymorphism of the <i>IGF-1</i> gene and the structure of motor skills in young athletes

Upper Extremity Strength Imbalance after Mastectomy and the Effect of Resistance Training

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