Interaction of anticancer drug mitoxantrone with DNA hexamer sequence d-(CTCGAG)2 by absorption, fluorescence and circular dichroism spectroscopy

The Interaction Mode of Groove Binding Between Quercetin and Calf Thymus DNA Based on Spectrometry and Simulation

“…If the conformation of DNA changes considerably, this is indicative of intercalative binding. On the contrary, when the conformation of DNA remains mostly unchanged, this is an indication that groove binding or electrostatic interaction has occurred . Q was added to the CT‐DNA solution in different concentrations, and then, circular dichroism spectra were recorded.…”

Evaluation of interaction between imidazolium-based chloride ionic liquids and calf thymus DNA

“…DNA also provides essential information, templates, and necessary tools for the synthesis of proteins. Therefore, the nature of binding of organic chemical contaminants (small molecules) with DNA has been intensively investigated, not only to understand the mechanism of toxicity of such interactions, but also to guide the design of new drugs against them (Kozurkova et al, 2008;Dogra et al, 2013). The interaction of environmental pollutants with DNA has recently attracted interest.…”

Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

“…In particular, bands in the 360–430 nm, 510–525 nm and 470–544 nm range appear in the Isoa, b and c-DNA system, respectively. The induced circular dichroism bands, as found in the investigation of the interaction between the anticancer drug mitoxantrone with DNA, are much smaller in intensity as compared to the positive and negative DNA bands and their variation cannot be determined due to large noise in those regions [40]. However, the presence of these bands reveals that all the isophorone derivatives are able to interact with ds-DNA.…”