Interaction of BMI with vitamin D and insulin sensitivity

Ou, Horng Yih; Karnchanasorn, Rudruidee; Lee, Lauren Z.; Chiu, Ken C.

doi:10.1111/j.1365-2362.2011.02525.x

Cited by 30 publications

(30 citation statements)

References 37 publications

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“…A study in healthy, non-diabetic adults with normal glucose tolerance showed a positive correlation of 25OHD and insulin sensitivity: the rise in 25OHD from 25–80 nnoml/l might increase insulin sensitivity by 60%, suggesting as vitamin D supplementation could be an adjunctive therapy in diabetes mellitus [33]. Furthermore, epidemiological studies, in patients with T2DM show a significant relationship between low 25OHD levels and reduced glucose tolerance [34–36].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus

et al. 2016

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BackgroundVitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among children with T1DM and its relationship with insulin sensitivity and glycemic status.Subjects and MethodsA cross sectional study was carried out between 2008–2014. A total of 141 patients had a T1DM >12 months diagnosis and were enrolled in the present study. Of these 35 (24.8%) were migrants and 106 (75.2%) Italians (T2). We retrospectively analyzed data at the onset of the disease (T0)(64 subjects) and 12–24 months before the last visit (T1,124 subjects). Fasting glucose, glycated hemoglobin (HbA1c), 25OHD levels and daily insulin requirement were evaluated and Cholecalciferol 1000 IU/day supplementation for the management of vitamin D insufficiency (<75 nmol/L) was systematically added.ResultsA generalized 25OHD insufficiency was found at each study time, particularly in migrants. At T0, the 25OHD levels were inversely related to diabetic keto-acidosis (DKA) severity (p<0.05). At T1 and T2, subjects with 25OHD ≤25nmol/L (10 ng/mL) showed higher daily insulin requirement (p<0.05) and HbA1c values (p<0.01) than others vitamin D status. The 25OHD levels were negatively related with HbA1c (p<0.001) and daily insulin dose (p<0.05) during follow up. There was a significant difference in 25OHD (p<0.01) between subjects with different metabolic control (HbA1c <7.5%,7.5–8%,>8%), both at T1 and T2. In supplemented subjects, we found a significant increase in 25OHD levels (p<0.0001) and decrease of HbA1c (p<0.001) between T1 and T2, but this was not significant in the migrants subgroup. Multivariate regression analysis showed a link between HbA1c and 25OHD levels (p<0.001).ConclusionsChildren with T1DM show a generalized 25OHD deficiency that impact on metabolic status and glycemic homeostasis. Vitamin D supplementation improves glycemic control and should be considered as an additional therapy.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus

et al. 2016

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“…However, this finding is consistent with two cross-sectional studies reporting stronger associations between 25(OH)D and HbA1c and insulin sensitivity, respectively, in persons with higher versus lower BMI. 34,35 On the one hand this suggests that overweight and obese individuals are more susceptible to the adverse effects of low vitamin D than normal weight persons. For example overweight and obese individuals may have an increased need for vitamin D in order to maintain normal glucose homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Serum 25(OH)D and incident type 2 diabetes: a cohort study

et al. 2012

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BACKGROUND/OBJECTIVES: Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum 25-hydroxy vitamin D (25(OH)D) and incident diabetes. SUBJECTS/METHODS: The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) who participated in a 10-year follow-up examination during 1993-1994 as part of the MONICA 1 population survey. A total of 2571 participants free of diabetes at baseline and with successful measurement of serum 25(OH)D were included in the current study. The Danish National Diabetes register enabled identification of 288 cases of incident diabetes during follow-up (median: 16.4 years). Data were analysed by Cox proportional hazard models and associations were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).

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“…43 Ou et al observed stronger associations of serum 25OHD with insulin sensitivity in overweight than normal weight subjects, suggesting that overweight subjects with hypovitaminosis D may benefit more from vitamin D replacement than normal weight subjects. 44 Regarding the correlation between UCOC and HbA1c in children with type 1 diabetes mellitus (T1DM), our study displayed a significant negative correlation (r=-0.182, p<0.037) between these parameters indicating the lower UCOC, the worse glycaemic control in children with T1DM.…”

Section: Discussionmentioning

confidence: 62%