Interaction of Carbon Nanomaterials and Components in Biological Systems

Ge, Cuicui

doi:10.1002/9783527692866.ch4

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Internalization Of Go In Cancer Cell Lines1

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2018

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“…46 Recent studies of the cellular uptake of nanometer-sized GO confirm its internalization in lysosomes. [47][48][49][50] Given the fact that GO reduces the viability of C33 cells, lysosomal activation may serve as a cellular mecha- nism of protection against cell death as described for other anticancer drugs. 51,52 It seems that lysosomes, which are an obstacle in the delivery of many drugs, are actually beneficial to overcome tumor cell resistance to gemcitabine.…”

Section: Internalization Of Go In Cancer Cell Linesmentioning

confidence: 99%

Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

Sohová

Bodík

Šiffalovič

et al. 2018

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Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy. The nanometer-sized GO is known to permeate cell membranes. Herein we studied the cellular uptake pathways of GO nanoflakes by cancer and non-cancerous cell lines. By employing confocal Raman imaging, we were able to track the GO cellular uptake in living cells (C33 and MDCK) without any additional fluorescent or plasmonic labels. This specific progress in label-free Raman imaging of GO facilitates the monitoring of nanoflakes at the cellular level.

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