Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth

Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line

“…The monoclonal antibody used in our study was specific against both MT-I and MT-II. Recently, Fong et al [35] demonstrated that mRNA expression of MTs-I and -II was induced in the growth plate of wild-type mice fed a Zn-limited diet. The difference in our results between the expression of protein and mRNA might be partly ascribed to MT-II expression.…”

Effects of thirty elements on bone metabolism

“…Zinc may also affect several aspects of osteoblast differentiation, presumably by modulating gene expression of runtrelated transcription factor 2 (Runx2) [321,322]. In osteoclasts, zinc inhibits the RANKL and TNF␣ differentiation pathways [315,317]. The consequences of zinc accretion in the skeleton are also notable [64].…”

“…A study by Ovesen et al [311] supports the idea that the beneficial effects of zinc on bone metabolism are similar to the effects of growth hormone and insulin-like growth factor 1. Zinc storage proteins, like metallothionein, and zinc transporters are particularly important in zinc homeostasis and are implicated in osteoblast-induced mineralization [310,317]. Alkaline phosphatase, collagenase, and aminoacyl-tRNA synthetase are some of the zinc-dependent enzymes, which can impact bone metabolism and are likely to be affected by imbalanced zinc levels [64,315,318].…”

Update on Zinc Biology

“…At the cellular level in the functional cells of bone, MT is important in regulating bone growth [45]. Zinc deficiency leads to lower chondrocyte proliferation, reduced metaphysis heights, along with increased osteoclast density.…”