Interaction of dipyridamole derivatives with lipids in mixed floating Langmuir monolayers

Langmuir films containing ibuprofen and phospholipids

“…Furthermore, considerable effects could be observed with very small ibuprofen concentrations. This points to the presence of cooperative effects, analogously to what has been reported for other drugs, such as dipyridamole [24] and phenotiazine derivatives [25].…”

Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

“…PM-IRRAS experiments confirmed the earlier observation [241] that the drug interacts peripherally with the zwitterionic lipid headgroup, but does not intercalate deeply between lipid molecules [239]. Apolar interactions were found to be important only for DIP hydrophobic derivatives [242].…”

“…Typical examples include: antimicrobials [117,, anti-tumorals [116,, antiinflammatory [77,[214][215][216][217], anesthesics [218][219][220][221][222][223][224][225][226][227], anti-psychotics [228][229][230][231][232][233][234][235][236][237], cardiac [238][239][240][241][242][243][244][245] and antihistaminic [246] drugs. To address this issue, Langmuir monolayers have been used involving AmB alone as well as mixed with membrane sterols.…”

Modeling Kinetics of Subcellular Disposition of Chemicals

“…( 441 ) The surface pressure versus area measurement, combined with other techniques, provides a basis for the inference about the approximate positions of interacting chemicals in the monolayer. 445 , 446 Surfactants, amphiphilic compounds with clearly separated polar and nonpolar parts, reduce the surface pressure at the air/water and lipid/water interfaces.…”

“…441 The surface pressure versus area measurement, combined with other techniques, provides a basis for the inference about the approximate positions of interacting chemicals in the monolayer. 445,446 Surfactants, amphiphilic compounds with clearly separated polar and nonpolar parts, reduce the surface pressure at the air/water and lipid/water interfaces. The lateral dimensions of the monolayer allow the use of a broad palette of techniques, ranging from electrochemical methods such as the surface potential measurements, 445 to analytical methods that examine the composition of the aqueous phase, and surface imaging.…”