Interaction of endothelium with dilation produced by inhibitors of cyclic nucleotide diesterases in mouse brain arterioles in vivo.

Rosenblum, William I.; Shimizu, Takao; Nelson, Guy H.

doi:10.1161/01.str.24.2.266

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…However, it is not known if the cGMP response to electrical stimulation or SNP is specifically localized to vascular smooth muscle. cGMP‐dependent vasodilation of arterioles has been reported in rat cremaster muscle [20]and other tissues [21, 22]. We also find that the arteriolar response to contraction in cremaster muscles from mdx mice was attenuated, providing physiological evidence consistent with our hypothesis.…”

Section: Discussionsupporting

confidence: 90%

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide

et al. 1998

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Nitric oxide generated by neuronal nitric oxide synthase in contracting skeletal muscle fibers may regulate vascular relaxation via a cGMP-mediated pathway. Neuronal nitric oxide synthase content is greatly reduced in skeletal muscles from mdx mice. cGMP formation increased in contracting extensor digitorum longus muscles in vitro from C57 control, but not mdx mice. The increase in cGMP content was abolished with N G -nitro-L-arginine. Sodium nitroprusside treatment increased cGMP levels in muscles from both C57 and mdx mice. Skeletal muscle contractions also inhibited phenylephrine-induced phosphorylation of smooth muscle myosin regulatory light chain. Arteriolar dilation was attenuated in contracting muscles from mdx but not C57 mice. NO generated in contracting skeletal muscle may contribute to vasodilation in response to exercise.z 1998 Federation of European Biochemical Societies.

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Section: Discussionsupporting

confidence: 90%

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide

et al. 1998

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“…Several studies have also shown the dilatory effects of dipyridamole as more or less selective phosphodiesterase inhibitors on intact cerebral arteries (Harris et al, 1989;Cosentino et al, 1992;Parfenova et al, 1993;Rosenblum et al, 1993;Willette et al, 1997). The present study demonstrated that dipyridamole induced only small changes in [Ca 2+ ]i in testicular or cerebral arteriole smooth muscle cells, and no dilation was observed in these arterioles.…”

Section: Response Of Smooth Muscle Cells In Testicular and Cerebral Asupporting

confidence: 68%

Dipyridamole inhibits intracellular calcium transients in isolated rat arteriole smooth muscle cells

Saino

Misaki

Matsuura

et al. 2008

Archives of Histology and Cytology

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“…In studies on animals, most nonselective and selective PDE inhibitors induce cerebral artery dilatation, although with different potency depending on species and vessels tested. Selective PDE3 inhibitors show effective endothelial independent relaxation, whereas PDE1, PDE4, and PDE5 inhibitors elicit endothelial-dependent relaxation (Kruuse et al, 2001;Parfenova et al, 1993;Rosenblum et al, 1993). The headache was scored on a verbal scale from 0 to 10; accompanying symptoms were graded none, minor, moderate, or severe.…”

Section: Cyclic Nucleotides Phosphodiesterases and Cerebral Vasodilmentioning

confidence: 99%

The Phosphodiesterase 5 Inhibitor Sildenafil Has No Effect on Cerebral Blood Flow or Blood Velocity, but Nevertheless Induces Headache in Healthy Subjects

Kruuse

Thomsen

Jacobsen

et al. 2002

J Cereb Blood Flow Metab

109

125

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Cyclic nucleotides are important hemodynamic regulators in many tissues. Glyceryl trinitrate markedly dilates large cerebral arteries and increases cGMP. Here, the authors study the effect of sildenafil, a selective inhibitor of cGMP-hydrolyzing phosphodiesterase 5 on cerebral hemodynamics and headache induction. Ten healthy subjects were included in a double-blind, placebo-controlled crossover study where placebo or sildenafil 100 mg (highest therapeutic dose) were administered on two separate days. Blood velocity in the middle cerebral artery (Vmca) was recorded by transcranial Doppler, and regional cerebral blood flow in the perfusion area of the middle cerebral artery (rCBFmca) was measured using single photon emission computed tomography and xenon inhalation. Radial and temporal artery diameters were studied using high-frequency ultrasound. Blood pressure and heart rate were recorded repeatedly. Headache responses and tenderness of pericranial muscles were scored verbally. Sildenafil caused no significant changes in rCBFmca, Vmca, or in temporal or radial artery diameter, but heart rate increased and diastolic blood pressure decreased significantly compared to placebo. Despite the lack of cerebral arterial dilatation, sildenafil caused significantly more headache than placebo. The present results show that sildenafil 100 mg does not dilate cerebral or extracerebral arteries but nevertheless causes headache, which may be attributed to nonvascular mechanisms.

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Interaction of endothelium with dilation produced by inhibitors of cyclic nucleotide diesterases in mouse brain arterioles in vivo.

Abstract: Background and Purpose: In vitro evidence gathered from extracerebral conductance vessels suggests

Cited by 16 publications

References 23 publications

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide

Dipyridamole inhibits intracellular calcium transients in isolated rat arteriole smooth muscle cells

The Phosphodiesterase 5 Inhibitor Sildenafil Has No Effect on Cerebral Blood Flow or Blood Velocity, but Nevertheless Induces Headache in Healthy Subjects

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