Interaction of hydrophobic organic compounds with mercury adsorbed dioleoylphosphatidylcholine monolayers

Immunotoxic effect of Benzo[α]Pyrene and chrysene in juvenile white shrimp Litopenaeus vannamei

“…PAHs, is one of a group of highly lipophilic organic compounds, they are able to penetrate model membrane systems [29], and then bind to membrane lipids which compromise basic cellular function by altering fluidity and ionic pumps [30], which is one reason of the decrease in THC. Once the PAHs are taken up by an organism, these PAHs undergo biotransformation reactions through two ways, during the reactions, reactive oxygen species (ROS) and inermediate hydrosoluble metabolites were stimulated to produce, and thereby damage biological macromolecules and tissue structures [31], which is another reason for the decrease of THC.…”

Substituents modulate biphenyl penetration into lipid membranes

“…According to some studies, non-planar o-substituted BPs increased the cell membrane leakiness and decreased the membrane integrity compared to the planar BPs [17][18][19]. While other studies have shown the non-planar o-substituted molecules to be less active compared to the planar p-substituted molecules because of the steric hindrance of the osubstituted species which influences their penetration into the phospholipid membrane [20][21][22].…”

“…The present study is an attempt to widen and deepen the work begun in reference [22] by extending the electrochemical methods and supporting them with additional techniques. An important objective of this work was to obtain an understanding of the fundamental molecular properties of aromatic and associated molecular species which enhance their interaction with phospholipid membranes as a model for biological membranes.…”

“…Indeed reference [22] used electrochemical methods in a preliminary study of the relation between the biphenyl's structure and their interaction with lipid layers however no understanding was developed concerning a systematic structure-activity relationship.…”

“…Monolayers of phospholipids on the Hg surface act as a sensor element for aromatic compounds and many other species including biomembrane-active peptides and nanoparticle dispersions [22,[26][27][28][29][30][31][32][33][34][35]. At potentials around -0.4 V which is close to the position of zero charge (PZC) of Hg, the Hg supported DOPC monolayer is completely intact and impermeable to inorganic ions.…”