1998
DOI: 10.1152/jappl.1998.85.6.2227
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Interaction of hyperthyroidism and hindlimb suspension on skeletal myosin heavy chain expression

Abstract: We examined the novel interaction of hyperthyroidism and hindlimb suspension on the pattern of myosin heavy chain (MHC) expression (mRNA and protein) in skeletal muscles. Female Sprague-Dawley rats were assigned to four groups: 1) normal control (Con); 2) thyroid hormone treated [150 micrograms 3,5,3'-triiodothyronine (T3). kg-1. day-1] (T3); 3) hindlimb suspension (HS); or 4) T3-treated and HS (T3 + HS). Results show for the first time the novel observation that the combination T3 + HS induces a rapid and sus… Show more

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Cited by 49 publications
(82 citation statements)
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“…This MHC expression profile demonstrates a dramatic shift from slow to fast MHC isotypes in these slow muscles with 7 days of SI. These results are consistent with previous reports of MHC gene switching patterns during unloading and/or inactivity of target muscles (6,8,9).…”
Section: Effects Of Si On Musclesupporting
confidence: 93%
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“…This MHC expression profile demonstrates a dramatic shift from slow to fast MHC isotypes in these slow muscles with 7 days of SI. These results are consistent with previous reports of MHC gene switching patterns during unloading and/or inactivity of target muscles (6,8,9).…”
Section: Effects Of Si On Musclesupporting
confidence: 93%
“…4B), the evolutionary conservation of the intergenic region, the gene orientation, and detection of the aII transcript within ϳ400 bp upstream of the IIx promoter all provide support for the intriguing possibility that sense and antisense transcription is activated by a bidirectional promoter. Transcription of an inhibitory molecule to IIa MHC gene expression linked to that of IIx MHC gene transcription provides a simple explanation for the IIa to IIx MHC "shift" that is reported here and elsewhere (6).…”
Section: Targetsupporting
confidence: 65%
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“…1) activates thyroid response elements on the IIb promoter to engage transcriptional activity and thus may override any negative influence of the bII NAT. The strength of this T3 influence on IIb MHC activation is demonstrated when a slow muscle is impacted by hindlimb suspension, which creates a transcriptionally permissive environment for IIb MHC expression and results in a sevenfold increase in IIb MHC mRNA in the soleus (22). If rats were induced to be hyperthyroid, by administration of T3, in addition to hindlimb suspension, then IIb mRNA levels are increased 21-fold above normal conditions, demonstrating the powerful synergistic effect of T3 with unloading (22).…”
Section: Discussionmentioning
confidence: 99%