Interaction of Iron(III) with 2-Hydroxybenzoic Acid in Aqueous Solutions

Furia, Emilia; Sindona, Giovanni

doi:10.1021/je201008x

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…Spectrophotometric procedures have also been used to establish the stability constants of Fe(III) salicylates [6]. Alternatively, the stability constants can be determined using potentiometric titrations [7][8][9][10]. In the course of such experiments, different complex structures and compositions have been proposed, but, to our knowledge, none of them have been characterized by a crystal structure analysis.…”

Section: Introductionmentioning

confidence: 99%

Crystallization, Structure Determination and Reticular Twinning in Iron(III) Salicylate: Fe[(HSal)(Sal)(H2O)2]

2017

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Abstract:In this contribution, we present the first crystal structure of iron(III) salicylate without additional counterions. The octahedral complex contains two salicylate and two water molecules as ligands. One salicylate is mono-anionic while the other is di-anionic. Because of the centrosymmetry of the complex, the acidic hydrogen atom is disordered on the midpoint between two salicylate oxygens. The structure determination of the tiny crystal indicates the presence of reticular twinning. The structure solution of the twin is shown and an explanation based on the crystal packing is provided.

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Section: Introductionmentioning

confidence: 99%

Crystallization, Structure Determination and Reticular Twinning in Iron(III) Salicylate: Fe[(HSal)(Sal)(H2O)2]

2017

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“…In order to confirm the speciation model and the formation constants gained via potentiometry by spectroscopic techniques as already established for other systems [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], spectrophotometric titrations on solutions containing Mn 2+ and Amp at t = 25 °C and I = 0.15 mol L −1 were performed under different concentration conditions. As an example, experimental spectra recorded on solutions containing Mn 2+ and Amp at C M = 0.05 mmol L −1 and C L = 0.05 mmol L −1 , were depicted in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

Interaction of Ampicillin and Amoxicillin with Mn2+: A Speciation Study in Aqueous Solution

Foti

Giuffrè

2020

Molecules

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A potentiometric and UV spectrophotometric investigation on Mn2+-ampicillin and Mn2+-amoxicillin systems in NaCl aqueous solution is reported. The potentiometric measurements were carried out under different conditions of temperature (15 ≤ t/°C ≤ 37). The obtained speciation pattern includes two species for both the investigated systems. More in detail, for system containing ampicillin MLH and ML species, for that containing amoxicillin, MLH2 and MLH ones. The spectrophotometric findings have fully confirmed the results obtained by potentiometry for both the systems, in terms of speciation models as well as the stability constants of the formed species. Enthalpy change values were calculated via the dependence of formation constants of the species on temperature. The sequestering ability of ampicillin and amoxicillin towards Mn2+ was also evaluated under different conditions of pH and temperature via pL0.5 empirical parameter (i.e., cologarithm of the ligand concentration required to sequester 50% of the metal ion present in traces).

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“…On the other hand, DHEA was found to reduce the levels of PGE 2 and other COX-2-derived eicosanoids without affecting COX-2 at gene expression level [21]. COX-2 represents a potential therapeutic target in many inflammation-associated disorders [35,36,37,38]. In addition, in the present work, we demonstrated that the apparent anti-inflammatory effects found in the murine RAW 264.7 macrophages could be reproduced in a cell line of human origin, as we found that MCP-1 and IL-6 production was decreased upon treatment with EPDA, at the concentration of 1 µM, in LPS-stimulated THP-1 macrophages.…”

Section: Discussionmentioning

confidence: 99%

N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages

et al. 2019

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A large body of evidence suggests that dietary n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), contribute to a reduced inflammatory tone thereby lowering the risk for several chronic and degenerative diseases. Different mechanisms have been proposed to explain these anti-inflammatory effects, including those involving endocannabinoids and endocannabinoid-like molecules. In this context, fatty acid amides (FAAs), conjugates of fatty acids with amines or amino acids, are an emerging class of compounds. Dopamine conjugates of DHA (N-docosahexaenoyl dopamine, DHDA) and EPA (N-eicosapentaenoyl dopamine, EPDA) have previously been shown to induce autophagy, apoptosis, and cell death in different tumor lines. Additionally, DHDA has displayed anti-inflammatory properties in vitro. Here, we tested the immune-modulatory properties of EPDA in mouse RAW 264.7 and human THP-1 macrophages stimulated with lipopolysaccharide (LPS). EPDA suppressed the production of monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both cell lines, and nitric oxide (NO), and macrophage-inflammatory protein-3α (MIP3A) in RAW 264.7 macrophages. At a transcriptional level, EPDA attenuated cyclooxygenase-2 (COX-2) expression in both cell lines and that of MCP-1, IL-6, and interleukin-1β (IL-1β) in THP-1 macrophages. Although further research is needed to reveal whether EPDA is an endogenous metabolite, our data suggest that this EPA-derived conjugate possesses interesting immune-modulating properties.

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Interaction of Iron(III) with 2-Hydroxybenzoic Acid in Aqueous Solutions

Cited by 17 publications

References 12 publications

Crystallization, Structure Determination and Reticular Twinning in Iron(III) Salicylate: Fe[(HSal)(Sal)(H2O)2]

Crystallization, Structure Determination and Reticular Twinning in Iron(III) Salicylate: Fe[(HSal)(Sal)(H2O)2]

Interaction of Ampicillin and Amoxicillin with Mn2+: A Speciation Study in Aqueous Solution

N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages

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