2001
DOI: 10.1128/jvi.75.3.1476-1486.2001
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Interaction of JC Virus Agno Protein with T Antigen Modulates Transcription and Replication of the Viral Genome in Glial Cells

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Cited by 97 publications
(133 citation statements)
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“…As shown in Figure 2A, YB-1-induced expression of viral early promoter is substantially suppressed by agnoprotein in a dose-dependent manner (lanes 3 and 4), indicating the functional interaction between these two proteins. As previously observed for viral late promoter (Safak et al, 2001), agnoprotein also suppressed the basal expression of viral early promoter (lane 5). Additionally, our preliminary cotransfection experiments indicate that agnoprotein also appears to suppress YB-1-mediated transactivation from JCV late promoter (data not shown).…”
supporting
confidence: 61%
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“…As shown in Figure 2A, YB-1-induced expression of viral early promoter is substantially suppressed by agnoprotein in a dose-dependent manner (lanes 3 and 4), indicating the functional interaction between these two proteins. As previously observed for viral late promoter (Safak et al, 2001), agnoprotein also suppressed the basal expression of viral early promoter (lane 5). Additionally, our preliminary cotransfection experiments indicate that agnoprotein also appears to suppress YB-1-mediated transactivation from JCV late promoter (data not shown).…”
supporting
confidence: 61%
“…Following the onset of DNA replication, the virus enters the late phase of infection during which capsid proteins are encoded, virions are matured, and nally the host cell is lysed (Raj and Khalili, 1995). Recently, we have presented evidence that, like large T-antigen, agnoprotein of JCV also participates in regulation of viral DNA replication and transcription (Safak et al, 2001).…”
mentioning
confidence: 99%
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“…In one study, the expression of the JCV late protein, Agnoprotein, was detected in 69% of tumor samples (Del Valle et al, 2002a). Agno is an auxiliary protein whose function remains unclear; however, recently it has been shown to be expressed early in viral infection and can interact with T-antigen to regulate viral transcription and replication (Safak et al, 2001). Interestingly, in human tumor samples, Agnoprotein has been found to be expressed in the cytoplasm of tumor cells and its expression does not appear to correlate with the expression of T-antigen.…”
Section: Association Of Jcv With Human Brain Tumorsmentioning
confidence: 99%
“…All other constructs containing JCV T-antigen mutants, that is, T 1-265 , T 1-265DNLS , and T 1-81 , were created with PCRgenerated fragments, using a JCV early-genome template in a pcDNA6/Myc-His version B background (Invitrogen). All GST-T-antigen constructs have been described previously (Safak et al, 2001). The pCS2MT4145 b-catenin was obtained from Dr Franc¸ois Fagotto (Xu et al, 2000).…”
Section: Plasmidsmentioning
confidence: 99%