2023
DOI: 10.1016/j.exger.2023.112306
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Interaction of Klotho and sirtuins

Farzaneh Rostamzadeh,
Yasamin Moosavi-Saeed,
Mahboobeh Yeganeh-Hajahmadi
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Cited by 5 publications
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“…Previous studies have shown Sirtuin 1 is involved in insulin release and the regulation of klotho. Klotho may antagonize oxidative stress, activate cellular autophagy, and inhibit neuroinflammation to reduce cognitive impairment by affecting the AMPK/SIRT1 signaling pathway, which plays an important role in glucose regulation, neuron proliferation, oxidative stress, and cognition ( 30 32 ).. Klotho also upregulates antioxidant enzymes like superoxide dismutase to bolster neuronal defenses against oxidative damage ( 33 ).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have shown Sirtuin 1 is involved in insulin release and the regulation of klotho. Klotho may antagonize oxidative stress, activate cellular autophagy, and inhibit neuroinflammation to reduce cognitive impairment by affecting the AMPK/SIRT1 signaling pathway, which plays an important role in glucose regulation, neuron proliferation, oxidative stress, and cognition ( 30 32 ).. Klotho also upregulates antioxidant enzymes like superoxide dismutase to bolster neuronal defenses against oxidative damage ( 33 ).…”
Section: Discussionmentioning
confidence: 99%