Interaction of low-intensity nuclear radiation dose with the human blood: Using the new technique of CR-39NTDs for an in vitro study

Ismail, Asaad H.; Jaafar, Mohamad Suhaimi

doi:10.1016/j.apradiso.2010.11.004

Cited by 23 publications

(14 citation statements)

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“…Effects of ionizing radiations have been observed through decreasing trends in MCH and MCHC levels, and an increasing trend in lymphocytes and RBC levels. Increased RBC levels have also been identified in a study in which irradiated human blood samples from Radium-226 source were analyzed through CBC reports [110]. Previous studies show that radiation can induce an anemic condition followed by radiation-induced hypoxemia, which can provoke higher production of red blood cells.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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Section: Discussionmentioning

confidence: 99%

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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“…Five pieces of the CR-39NTDs (1.5 cm × 1 cm) irradiated by the source of radium source ( 226 Ra). The principle of irradiation depended on the distance between the source and the surface of CR-39NTDs using suitable irradiation collimators that fabricated in previous work [6]. Different length of an irradiation collimator given different expose dose rate (µSv/hr), as shown in Figure 1(a).…”

Section: Irradiation Of Cr-39ntdsmentioning

confidence: 99%

“…The use of some alpha emitter radionuclides, such as 226 Ra and 241 Am, in nuclear medicine is due to their low tissue penetration, with reduced toxicity to neighboring tissues [12]. In the previous work [6], 226 Ra use as a pure source of high-energy alpha particles is of particular interest. And the effects of deposition of alpha particles onto the healthy cells of human blood samples for different exposure dose and time of exposure have been investigated using the alpha irradiation collimator being in direct contact with the blood sample.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, high linear energy transfer (LET) radiation (alpha particles and fission fragments) is more efficient in inducing biological damage than low LET radiation (gamma ray, X-rays, and β-particles) [4]. This is because most of the incident energy will be deposited within a short distance, causing dense ionization in the trajectory [5][6][7]. Ionizing radiation breaks down and destabilizes the molecules, and this is particularly true for biomolecules, including DNA.…”

Section: Introductionmentioning

confidence: 99%

“…Deposition of the alpha particles into the tissues and cells may cause damage (temporary and permanent), depending on the time of exposure, energy of the alpha particles, and quantity of the absorbed dose. Thus, studies on the risks of radiation have been carried out for a long time and research on the techniques is novel [6].…”

Section: Introductionmentioning

confidence: 99%

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Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: <i>In Vitro</i>

Ismail¹,

Hamad²,

Harki³

2012

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Complete blood counts were analyzed for 12 samples (six males & six females: Ages 15 -40 years) of leukemia blood Samples for different dose rate and time of exposure using a Radium-226 source. Thus, an optimum time of exposure and exposure dose rate has improved for leukemia blood samples. Blood samples fractionated and placed in plastic wills, and melodic Coulter used to analysis exposed leukemia blood samples before and after exposure. Exposure technique involving CR-39 nuclear track detector and radiation survey dosimeter were used to estimate the alpha particle density incident on the blood samples and the exposed dose rate, respectively. In the first part, density of the accumulation of alpha particle on the surface of leukemia blood samples, and on the surface of CR-39NTDs varies exponentially with the exposed dose rate. This depends on the restricted energy loss of the incident alpha particles and target density. Assess an optimum time of exposure dose rate (1100 µSv/h) was the second objective. This depended on the changes in the blood components (PLT, WBC, and RBC) due to irradiation occurred for different durations of irradiation, and the duration of irradiation that influenced the leukemia blood samples (1 Male, 16 years and one Female 17 years) in this research was five minutes. Changes in the density of PLT, WBC, and RBC for leukemia blood samples and for different male (five males) and female (five females) was the third part of this research. It was found that the changes were variables due to the exposed dose rate. Optimum exposed dose rate to make more effects on the cancer cells for the leukemia blood samples began at the radiation dose rate of 43.25  1.206 µSv/h for both; male and female relatively, and this due to chromosomal aberration of the exposed cells. Finally, comparison study with the healthy blood samples has been investigated. More details are listed and clarified in the tables and figures of this paper.

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The influence of very small doses of alpha radiation on the stability of erythrocytes

Kaczmarska

Żydek

Wilkłacz-Potoczny

et al. 2016

Microscopy Res & Technique

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Our aim was to study the influence of low doses (0.2-4 μGy) of α radiation on the stability of human erythrocytes isolated from healthy and diabetic erythrocytes. Absorption spectroscopy was used to measure the level of red blood cell (RBC) hemolysis, along with Mössbauer spectroscopy, which is a highly specific method suited to monitoring various hemoglobin forms. States of hemoglobin are sensitive to a homeostatic imbalance in red blood cells. Changes in the membrane skeleton organization of irradiated erythrocytes isolated from healthy donors were studied using atomic force microscopy (AFM). Hemolysis, in healthy red blood cells, showed characteristic discontinuities, depending on the α particle flux and the exposure time to the low doses applied. This phenomenon was not observed in severe diabetic cases, which could be a result of modified protein-lipid-sugar complexes and the attenuation/absence of some antioxidative enzymatic processes in their RBC membranes. Similar effects were also observed for red blood cells treated with low doses of neutron and γ-radiation. AFM measurements demonstrated a reorganization of the RBC membrane skeleton network depending on the time of RBC exposure to α radiation. This suggests that the changes in the activity of the acute defense processes against free radicals which are activated within the erythrocyte membrane irradiated with α-particles could additionally be up- or down regulated by modifications to the membrane-skeleton network. However, even the highest dose of α radiation applied in these studies did not cause any significant changes in the ability of hemoglobin to transport oxygen. Microsc. Res. Tech. 80:131-143, 2017. © 2016 Wiley Periodicals, Inc.

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Interaction of low-intensity nuclear radiation dose with the human blood: Using the new technique of CR-39NTDs for an in vitro study

Cited by 23 publications

References 13 publications

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: <i>In Vitro</i>

The influence of very small doses of alpha radiation on the stability of erythrocytes

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Interaction of low-intensity nuclear radiation dose with the human blood: Using the new technique of CR-39NTDs for an in vitro study

Cited by 23 publications

References 13 publications

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: &lt;i&gt;In Vitro&lt;/i&gt;

The influence of very small doses of alpha radiation on the stability of erythrocytes

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Product

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Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: <i>In Vitro</i>